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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of molecular function, epigenetic
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Accession:GO:0040030 term browser browse the term
Definition:Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.
Synonyms:exact_synonym: regulation of protein activity, epigenetic


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regulation of molecular function, epigenetic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Asip agouti signaling protein JBrowse link NW_004955422 27,021,810 27,150,339 RGD:9068941
G Ctcf CCCTC-binding factor JBrowse link NW_004955484 9,041,226 9,092,924 RGD:9068941

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  biological_process 14616
    biological regulation 10479
      regulation of molecular function 2799
        regulation of molecular function, epigenetic 2
          negative regulation of molecular function, epigenetic 0
          positive regulation of molecular function, epigenetic 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.