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ONTOLOGY REPORT - ANNOTATIONS

Term:suppression by virus of host STAT activity
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Accession:GO:0039562 term browser browse the term
Definition:Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT (signal transducer and activator of transcription) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
Comment:This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
Synonyms:exact_synonym: suppression by virus of host signal transducer and activator of transcription activity
 narrow_synonym: inhibition by virus of host STAT activity

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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19638
    cellular process 18484
      regulation of cellular process 12327
        suppression by virus of host STAT activity 0
          suppression by virus of host STAT1 activity 0
          suppression by virus of host STAT2 activity 0
Path 2
Term Annotations click to browse term
  biological_process 19638
    biological process involved in interspecies interaction between organisms 1817
      modulation of process of other organism 126
        modulation of process of other organism involved in symbiotic interaction 92
          modulation by symbiont of host process 25
            modulation by symbiont of host cellular process 14
              modulation by symbiont of host signal transduction pathway 1
                suppression by symbiont of host signal transduction pathway 0
                  suppression by virus of host JAK-STAT cascade 0
                    suppression by virus of host STAT activity 0
                      suppression by virus of host STAT1 activity 0
                      suppression by virus of host STAT2 activity 0
paths to the root