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ONTOLOGY REPORT - ANNOTATIONS


Term:TOR complex
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Accession:GO:0038201 term browser browse the term
Definition:A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K.
Synonyms:exact_synonym: TOR signaling complex;   target of rapamycin complex
 narrow_synonym: mTOR complex


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TORC1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 colocalizes_with ISO (PMID:17386266) RGD PMID:17386266 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator colocalizes_with ISO (PMID:24532714), (PMID:25940091) RGD PMID:24532714, PMID:25940091 NCBI chr10:43,435,738...43,501,186
Ensembl chr10:43,446,526...43,498,066
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO
IEA
IBA
(MGI:MGI:5816448|PMID:12718876)
GO_REF:0000107
PMID:21873635
(PMID:12718876), (PMID:24036451)
RGD
Ensembl
PMID:12718876, PMID:24036451, PMID:21873635 GO_REF:0000107, MGI:MGI:5816448, RGD:13792537 NCBI chr10:13,839,250...13,845,001
Ensembl chr10:13,839,250...13,845,001
JBrowse link
G Mtor mechanistic target of rapamycin kinase IDA
IBA
ISO
PMID:21873635
(PMID:12150926), (PMID:12718876), (PMID:15467718), (PMID:18925875), (PMID:20537536)
(MGI:MGI:5816448|PMID:12718876)
RGD PMID:12150926, PMID:12718876, PMID:15467718, PMID:18925875, PMID:20537536, PMID:17110594, PMID:21873635 MGI:MGI:5816448, RGD:2307383, RGD:13792537 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 ISO
IBA
(PMID:12150926), (PMID:12718876), (PMID:15467718), (PMID:24036451), (PMID:25940091)
PMID:21873635
RGD PMID:12150926, PMID:12718876, PMID:15467718, PMID:24036451, PMID:25940091, PMID:21873635 RGD:13792537 NCBI chr10:108,750,620...109,058,691
Ensembl chr10:108,750,620...109,058,691
JBrowse link
G Telo2 telomere maintenance 2 ISO
IBA
(PMID:23263282)
PMID:21873635
RGD PMID:23263282, PMID:21873635 RGD:13792537 NCBI chr10:14,461,581...14,476,812
Ensembl chr10:14,461,839...14,476,785
JBrowse link
G Tti1 TELO2 interacting protein 1 ISO
IBA
(PMID:23263282)
PMID:21873635
RGD PMID:23263282, PMID:21873635 RGD:13792537 NCBI chr 3:154,463,108...154,506,955
Ensembl chr 3:154,463,109...154,490,851
JBrowse link
TORC2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07051501.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 3:14,192,061...14,202,271 JBrowse link
G Mapkap1 MAPK associated protein 1 ISO
IBA
(MGI:MGI:3759333|PMID:16962653)
PMID:21873635
RGD PMID:16962653, PMID:21873635 MGI:MGI:3759333, RGD:13792537 NCBI chr 3:13,484,952...13,701,772
Ensembl chr 3:13,484,838...13,701,757
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO
IBA
IEA
(PMID:24036451)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:24036451, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr10:13,839,250...13,845,001
Ensembl chr10:13,839,250...13,845,001
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO
IBA
(PMID:15467718), (PMID:18925875)
PMID:21873635
RGD PMID:15467718, PMID:18925875, PMID:21873635 RGD:13792537 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Prr5 proline rich 5 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:22609986)
Ensembl
RGD
PMID:22609986, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 7:125,569,791...125,609,340
Ensembl chr 7:125,576,327...125,613,114
JBrowse link
G Prr5l proline rich 5 like IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:22609986)
Ensembl
UniProt
RGD
PMID:22609986, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 3:91,290,207...91,461,208
Ensembl chr 3:91,291,875...91,370,167
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 ISO
IBA
(PMID:15268862), (PMID:15467718), (PMID:24036451)
PMID:21873635
(MGI:MGI:3759333|PMID:16962653)
RGD PMID:15268862, PMID:15467718, PMID:16962653, PMID:24036451, PMID:21873635 MGI:MGI:3759333, RGD:13792537 NCBI chr 2:56,013,898...56,105,818
Ensembl chr 2:56,052,643...56,101,803
JBrowse link
G Sesn1 sestrin 1 colocalizes_with IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sesn2 sestrin 2 colocalizes_with ISO
IBA
(MGI:MGI:5779633|PMID:25377878)
PMID:21873635
RGD PMID:25377878, PMID:21873635 MGI:MGI:5779633, RGD:13792537 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sesn3 sestrin 3 colocalizes_with ISO
IBA
(MGI:MGI:5779633|PMID:25377878)
PMID:21873635
RGD PMID:25377878, PMID:21873635 MGI:MGI:5779633, RGD:13792537 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
G Telo2 telomere maintenance 2 ISO
IBA
(PMID:23263282)
PMID:21873635
RGD PMID:23263282, PMID:21873635 RGD:13792537 NCBI chr10:14,461,581...14,476,812
Ensembl chr10:14,461,839...14,476,785
JBrowse link
G Tti1 TELO2 interacting protein 1 ISO
IBA
(PMID:23263282)
PMID:21873635
RGD PMID:23263282, PMID:21873635 RGD:13792537 NCBI chr 3:154,463,108...154,506,955
Ensembl chr 3:154,463,109...154,490,851
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      TOR complex 15
        TORC1 complex 7
        TORC2 complex 12
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        TOR complex 15
          TORC1 complex 7
          TORC2 complex 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.