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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:neurotrophin signaling pathway
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Accession:GO:0038179 term browser browse the term
Definition:The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment:There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms:exact_synonym: neurotrophin receptor signaling pathway

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neurotrophin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chrNW_004936476:12,890,595...12,989,046
Ensembl chrNW_004936476:12,890,468...12,987,843 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936680:267,850...621,467
Ensembl chrNW_004936680:267,596...615,928 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936483:13,912,904...14,291,881
Ensembl chrNW_004936483:13,909,109...14,291,887 		JBrowse link
negative regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr2 angiotensin II receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570 		JBrowse link
G Ptprf protein tyrosine phosphatase receptor type F ISO NGF stimulated neurite outgrowth in PC12 cells RGD PMID:10699984 RGD:1642748 NCBI chrNW_004936474:24,908,103...24,984,678
Ensembl chrNW_004936474:24,908,120...24,983,330 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11585837) Ensembl
MGI		 PMID:11585837 GO_REF:0000107 NCBI chrNW_004936662:2,241,928...2,245,616
Ensembl chrNW_004936662:2,243,326...2,244,291 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (PMID:11585837) MGI PMID:11585837 NCBI chrNW_004936511:1,452,421...1,458,031 JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014 		JBrowse link
G Cd2ap CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chrNW_004936476:12,890,595...12,989,046
Ensembl chrNW_004936476:12,890,468...12,987,843 		JBrowse link
G Coro1a coronin 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24270184) Ensembl
MGI		 PMID:24270184 GO_REF:0000107 NCBI chrNW_004936501:12,338,542...12,344,236
Ensembl chrNW_004936501:12,338,542...12,344,265 		JBrowse link
G Kidins220 kinase D interacting substrate 220 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936532:5,270,338...5,368,160
Ensembl chrNW_004936532:5,272,149...5,362,814 		JBrowse link
G LOC101970905 neurotrophin-4-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936995:299,677...300,309 JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936479:21,373,917...22,062,498
Ensembl chrNW_004936479:21,373,746...21,920,214 		JBrowse link
G Ngf nerve growth factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7854358)
(PMID:24270184)		 TreeGrafter
MGI		 PMID:7854358 PMID:24270184 GO_REF:0000118 NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364 		JBrowse link
G Ntf3 neurotrophin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936709:2,163,510...2,223,429
Ensembl chrNW_004936709:2,163,334...2,223,552 		JBrowse link
G Ntf4 neurotrophin 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936664:3,017,108...3,017,955 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7854358)
(PMID:24270184)		 Ensembl
MGI
TreeGrafter		 PMID:7854358 PMID:24270184 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936580:6,002,168...6,021,690
Ensembl chrNW_004936580:6,002,120...6,021,709 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936690:275,840...363,752
Ensembl chrNW_004936690:315,752...366,413 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:17724123) UniProt PMID:17724123 NCBI chrNW_004936487:18,305,537...18,411,170
Ensembl chrNW_004936487:18,305,488...18,410,952 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chrNW_004936576:5,583,847...5,746,583
Ensembl chrNW_004936576:5,583,805...5,746,671 		JBrowse link
G Shoc2 SHOC2 leucine rich repeat scaffold protein ISO RGD PMID:25514808 RGD:155804270 NCBI chrNW_004936486:1,723,253...1,809,416 JBrowse link
G Sort1 sortilin 1 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936704:832,651...901,658
Ensembl chrNW_004936704:837,057...901,392 		JBrowse link
neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936664:3,657,170...3,664,375
Ensembl chrNW_004936664:3,657,207...3,664,024 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO PMID:8631760 UniProt PMID:8631760 RGD:8553306 NCBI chrNW_004936475:23,994,130...24,032,829
Ensembl chrNW_004936475:23,992,193...24,033,031 		JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO (PMID:23954828) MGI PMID:23954828 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Cd2ap CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chrNW_004936476:12,890,595...12,989,046
Ensembl chrNW_004936476:12,890,468...12,987,843 		JBrowse link
G Ddit4 DNA damage inducible transcript 4 involved_in ISO PMID:21368030 UniProt PMID:21368030 RGD:8554300 NCBI chrNW_004936521:6,646,864...6,648,982
Ensembl chrNW_004936521:6,646,797...6,648,983 		JBrowse link
G Hap1 huntingtin associated protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936490:16,645,116...16,652,310
Ensembl chrNW_004936490:16,643,520...16,652,479 		JBrowse link
G Ndn necdin, MAGE family member involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16049186) Ensembl
MGI		 PMID:16049186 GO_REF:0000107 NCBI chrNW_004936805:849,218...850,894
Ensembl chrNW_004936805:849,345...850,322 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:6,002,168...6,021,690
Ensembl chrNW_004936580:6,002,120...6,021,709 		JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12482708) Ensembl
MGI		 PMID:12482708 GO_REF:0000107 NCBI chrNW_004936668:2,602,261...2,687,903
Ensembl chrNW_004936668:2,628,706...2,682,448 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9852579) Ensembl
MGI		 PMID:9852579 GO_REF:0000107 NCBI chrNW_004936602:1,089,979...1,114,376
Ensembl chrNW_004936602:1,051,205...1,117,096 		JBrowse link
G Sort1 sortilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936704:832,651...901,658
Ensembl chrNW_004936704:837,057...901,392 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:15728722 RGD:1581104 NCBI chrNW_004936508:12,162,553...12,281,812
Ensembl chrNW_004936508:12,162,547...12,281,820 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:15546918 RGD:1580675 NCBI chrNW_004936561:3,826,802...3,844,406
Ensembl chrNW_004936561:3,825,787...3,844,483 		JBrowse link
G Zfyve27 zinc finger FYVE-type containing 27 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936636:1,979,287...2,003,696
Ensembl chrNW_004936636:1,979,172...2,003,769 		JBrowse link
positive regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:38,264,455...38,331,995
Ensembl chrNW_004936471:38,267,703...38,332,218 		JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936515:5,759,940...5,880,688
Ensembl chrNW_004936515:5,759,345...5,880,713 		JBrowse link
G Ngf nerve growth factor acts_upstream_of_or_within ISO PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364 		JBrowse link
G Ppp2r5b protein phosphatase 2 regulatory subunit B'beta acts_upstream_of_or_within ISO PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chrNW_004936599:4,403,107...4,411,407
Ensembl chrNW_004936599:4,401,557...4,411,391 		JBrowse link
G Sh3glb1 SH3 domain containing GRB2 like, endophilin B1 ISO RGD PMID:18768694 RGD:13504749 NCBI chrNW_004936732:2,066,848...2,097,947
Ensembl chrNW_004936732:2,067,204...2,097,631 		JBrowse link
G Tmem108 transmembrane protein 108 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:6,326,775...6,629,247
Ensembl chrNW_004936529:6,326,702...6,629,898 		JBrowse link
G Wasf1 WASP family member 1 involved_in ISO (MGI:5825407|PMID:27605705) UniProt PMID:27605705 MGI:5825407 NCBI chrNW_004936564:6,036,135...6,096,046 JBrowse link
regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dok5 docking protein 5 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23954828) MGI
Ensembl		 PMID:23954828 GO_REF:0000107 NCBI chrNW_004936514:1,073,067...1,219,340
Ensembl chrNW_004936514:1,073,002...1,219,659 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24035762) Ensembl
MGI		 PMID:24035762 GO_REF:0000107 NCBI chrNW_004936513:11,158,609...11,215,477
Ensembl chrNW_004936513:11,158,730...11,215,568 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 acts_upstream_of_or_within ISO (PMID:17389358) MGI PMID:17389358 NCBI chrNW_004936660:2,160,394...2,188,848
Ensembl chrNW_004936660:2,163,844...2,187,080 		JBrowse link
G Zdhhc17 zinc finger DHHC-type palmitoyltransferase 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936568:4,959,796...5,052,254
Ensembl chrNW_004936568:4,959,790...5,052,245 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    cellular process 15001
      signal transduction 5667
        cell surface receptor signaling pathway 2506
          neurotrophin signaling pathway 43
            nerve growth factor signaling pathway 15
            neurotrophin TRK receptor signaling pathway + 30
Path 2
Term Annotations click to browse term
  biological_process 15871
    biological regulation 11036
      regulation of biological process 10703
        signaling 6159
          signal transduction 5667
            cell surface receptor signaling pathway 2506
              neurotrophin signaling pathway 43
                nerve growth factor signaling pathway 15
                neurotrophin TRK receptor signaling pathway + 30
paths to the root