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ONTOLOGY REPORT - ANNOTATIONS

Term:neurotrophin signaling pathway
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Accession:GO:0038179 term browser browse the term
Definition:The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment:There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms:exact_synonym: neurotrophin receptor signaling pathway


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neurotrophin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd2ap CD2-associated protein acts_upstream_of_or_within ISO MGI:2664945 (PMID:27076424) RGD PMID:27076424 NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004 		JBrowse link
negative regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO
IEA 		(PMID:10406457)
GO_REF:0000107 		RGD
Ensembl		 PMID:10406457 GO_REF:0000107 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP NGF stimulated neurite outgrowth in PC12 cells RGD PMID:10699984 RGD:1642748 NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO
IEA 		(PMID:11585837)
GO_REF:0000107 		RGD
Ensembl		 PMID:11585837 GO_REF:0000107 NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:122,484,355...122,492,956 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO
IEA 		(PMID:11585837)
GO_REF:0000107 		RGD
Ensembl		 PMID:11585837 GO_REF:0000107 NCBI chr15:89,106,809...89,111,926
Ensembl chr15:89,103,731...89,115,074 		JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Cd2ap CD2-associated protein acts_upstream_of_or_within ISO MGI:2664945 (PMID:27076424) RGD PMID:27076424 NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968 		JBrowse link
G Coro1a coronin 1A acts_upstream_of_or_within ISO
IEA 		MGI:97321|MGI:97383 (PMID:24270184)
GO_REF:0000107 		RGD
Ensembl		 PMID:24270184 GO_REF:0000107 NCBI chr 1:190,726,129...190,731,133
Ensembl chr 1:190,726,130...190,731,102 		JBrowse link
G Kidins220 kinase D-interacting substrate 220 involved_in IDA
IBA 		PMID:17724123
GO_REF:0000033 		GO_Central PMID:17724123 GO_REF:0000033, RGD:8554481 NCBI chr 6:47,346,790...47,435,599
Ensembl chr 6:47,346,832...47,431,865 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:15,278,518...16,762,199 		JBrowse link
G Ngf nerve growth factor involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:1345961|MGI:97383 (PMID:24270184), (PMID:7854358) 		GO_Central
RGD		 PMID:7854358 PMID:24270184 GO_REF:0000033 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Ntf3 neurotrophin 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349 		JBrowse link
G Ntf4 neurotrophin 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:105,030,035...105,032,866
Ensembl chr 1:105,029,764...105,034,038 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA
IDA 		(PMID:1281417)
GO_REF:0000117
GO_REF:0000107
MGI:1345961|MGI:97321 (PMID:24270184), (PMID:7854358)
GO_REF:0000033
PMID:17724123 		RGD
UniProt
Ensembl
GO_Central		 PMID:1281417 PMID:7854358 PMID:24270184 PMID:17724123 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:8554481 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:17724123) RGD PMID:17724123 NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:33,296,230...33,414,119 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:166,505,868...166,726,698 		JBrowse link
G Shoc2 SHOC2 leucine-rich repeat scaffold protein involved_in IMP
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:25514808 GO_REF:0000033, RGD:155804270 NCBI chr 1:262,964,345...263,052,898
Ensembl chr 1:262,965,011...263,052,634 		JBrowse link
G Sort1 sortilin 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481 		JBrowse link
neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:104,469,803...104,476,167 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in IDA PMID:8631760 UniProt PMID:8631760 RGD:8553306 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:56,588,500...56,623,190 		JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO
IEA 		(PMID:23954828)
GO_REF:0000107 		RGD
Ensembl		 PMID:23954828 GO_REF:0000107 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cd2ap CD2-associated protein acts_upstream_of_or_within ISO MGI:2664945 (PMID:27076424) RGD PMID:27076424 NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in IMP PMID:21368030 UniProt PMID:21368030 RGD:8554300 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IEA
ISO
IBA
ISS 		GO_REF:0000107
(PMID:24355921)
GO_REF:0000033
GO_REF:0000024 		Ensembl
RGD
GO_Central
UniProt		 PMID:24355921 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:85,778,267...85,786,553
Ensembl chr10:85,778,267...85,786,503 		JBrowse link
G Mageh1 MAGE family member H1 NAS RGD PMID:12414813 RGD:729117 NCBI chr  X:18,350,015...18,351,271
Ensembl chr  X:21,718,669...21,727,219 		JBrowse link
G Ndn necdin, MAGE family member acts_upstream_of_or_within NAS
IEA
ISO 		GO_REF:0000107
MGI:3586988 (PMID:16049186) 		Ensembl
RGD		 PMID:16049186 PMID:12414813 GO_REF:0000107, RGD:729117 NCBI chr 1:125,261,059...125,262,658
Ensembl chr 1:125,260,997...125,262,785 		JBrowse link
G Ngf nerve growth factor involved_in ISO (PMID:19036963) RGD PMID:19036963 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:15488758) 		UniProt
Ensembl
RGD		 PMID:15488758 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO
IEA 		(PMID:12482708)
GO_REF:0000107 		RGD
Ensembl		 PMID:12482708 GO_REF:0000107 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO
IEA 		(PMID:9852579)
GO_REF:0000107 		RGD
Ensembl		 PMID:9852579 GO_REF:0000107 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Sort1 sortilin 1 involved_in ISO
IEA 		(PMID:14985763)
GO_REF:0000107 		RGD
Ensembl		 PMID:14985763 GO_REF:0000107 NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IMP RGD PMID:15728722 RGD:1581104 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:15546918 RGD:1580675 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Zfyve27 zinc finger FYVE-type containing 27 involved_in IMP
IBA 		PMID:17082457
GO_REF:0000033 		GO_Central PMID:17082457 GO_REF:0000033, RGD:8554602 NCBI chr 1:250,929,110...250,952,481
Ensembl chr 1:250,928,012...250,952,481 		JBrowse link
positive regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (PMID:27605705) RGD PMID:27605705 NCBI chr 1:115,842,754...115,935,163
Ensembl chr 1:115,846,661...115,951,292 		JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 involved_in ISO
IEA 		(PMID:27605705)
GO_REF:0000107 		RGD
Ensembl		 PMID:27605705 GO_REF:0000107 NCBI chr10:31,122,653...31,242,440
Ensembl chr10:31,122,653...31,242,440 		JBrowse link
G Ngf nerve growth factor acts_upstream_of_or_within IDA PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta acts_upstream_of_or_within IMP PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 1:203,527,268...203,535,442
Ensembl chr 1:212,956,533...212,964,662 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 IMP RGD PMID:18768694 RGD:13504749 NCBI chr 2:236,411,194...236,445,225
Ensembl chr 2:236,410,436...236,445,140 		JBrowse link
G Tmem108 transmembrane protein 108 involved_in ISO
IEA 		(PMID:21849472), (PMID:27605705)
GO_REF:0000107 		RGD
Ensembl		 PMID:21849472 PMID:27605705 GO_REF:0000107 NCBI chr 8:112,944,925...113,238,996
Ensembl chr 8:112,944,928...112,984,211 		JBrowse link
G Wasf1 WASP family member 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:27605705) 		Ensembl
RGD		 PMID:27605705 GO_REF:0000107 NCBI chr20:45,908,458...45,956,118
Ensembl chr20:45,908,750...45,955,640 		JBrowse link
regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dok5 docking protein 5 acts_upstream_of_or_within ISO
IEA 		(PMID:23954828)
GO_REF:0000107 		RGD
Ensembl		 PMID:23954828 GO_REF:0000107 NCBI chr 3:159,515,886...159,652,811
Ensembl chr 3:179,934,552...180,071,333 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 acts_upstream_of_or_within ISO MGI:3604561 (PMID:24035762) RGD PMID:24035762 NCBI chr  X:139,468,045...139,524,111
Ensembl chr  X:139,458,127...139,524,109 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 acts_upstream_of_or_within ISO (PMID:17389358) RGD PMID:17389358 NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746 		JBrowse link
G Zdhhc17 zinc finger DHHC-type palmitoyltransferase 17 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:26232532)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:26232532 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:48,256,269...48,320,000
Ensembl chr 7:48,257,856...48,320,160 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      signal transduction 7381
        cell surface receptor signaling pathway 2971
          neurotrophin signaling pathway 44
            nerve growth factor signaling pathway 14
            neurotrophin TRK receptor signaling pathway + 31
Path 2
Term Annotations click to browse term
  biological_process 20668
    biological regulation 13899
      regulation of biological process 13475
        signaling 7942
          signal transduction 7381
            cell surface receptor signaling pathway 2971
              neurotrophin signaling pathway 44
                nerve growth factor signaling pathway 14
                neurotrophin TRK receptor signaling pathway + 31
paths to the root