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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:neurotrophin signaling pathway
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Accession:GO:0038179 term browser browse the term
Definition:The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment:There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms:exact_synonym: neurotrophin receptor signaling pathway


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neurotrophin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfra1 GDNF family receptor alpha 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
negative regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO
IEA		 (PMID:10406457)
GO_REF:0000107		 RGD
Ensembl		 PMID:10406457 GO_REF:0000107 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP NGF stimulated neurite outgrowth in PC12 cells RGD PMID:10699984 RGD:1642748 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Coro1a coronin 1A acts_upstream_of_or_within ISO MGI:97321|MGI:97383 (MGI:5559799|PMID:24270184) RGD PMID:24270184 MGI:5559799 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Kidins220 kinase D-interacting substrate 220 involved_in IDA
IBA		 PMID:17724123
PMID:21873635		 UniProt
GO_Central		 PMID:17724123 PMID:21873635 RGD:8554481, RGD:13792537 NCBI chr 6:41,618,207...41,706,990
Ensembl chr 6:41,618,294...41,703,256 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240 		JBrowse link
G Ngf nerve growth factor involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1345961|MGI:97383 (MGI:5559799|PMID:24270184), (MGI:69378|PMID:7854358)		 RGD PMID:7854358 PMID:24270184 PMID:21873635 MGI:5559799 MGI:69378, RGD:13792537 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ntf3 neurotrophin 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntf4 neurotrophin 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within		 ISO
IDA
IBA		 (PMID:1281417)
MGI:1345961|MGI:97321 (MGI:5559799|PMID:24270184), (MGI:69378|PMID:7854358)
PMID:17724123
PMID:21873635		 RGD PMID:1281417 PMID:7854358 PMID:24270184 PMID:17724123 PMID:21873635 MGI:5559799 MGI:69378, RGD:8554481, RGD:13792537 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:17724123) RGD PMID:17724123 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247 		JBrowse link
G Shoc2 SHOC2 leucine-rich repeat scaffold protein IMP RGD PMID:25514808 RGD:155804270 NCBI chr 1:252,958,939...253,048,820
Ensembl chr 1:252,959,723...253,047,337 		JBrowse link
G Sort1 sortilin 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354 		JBrowse link
neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in IDA PMID:8631760 UniProt PMID:8631760 RGD:8553306 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO (PMID:23954828) RGD PMID:23954828 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in IMP PMID:21368030 UniProt PMID:21368030 RGD:8554300 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IEA
ISO
ISS
IBA		 GO_REF:0000107
(MGI:5560429|PMID:24355921)
GO_REF:0000024
PMID:21873635		 Ensembl
RGD
UniProt		 PMID:24355921 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5560429, RGD:13792537 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Mageh1 MAGE family member H1 NAS RGD PMID:12414813 RGD:729117 NCBI chr  X:18,350,015...18,351,271
Ensembl chr  X:18,349,774...18,351,516 		JBrowse link
G Ndn necdin, MAGE family member acts_upstream_of_or_within NAS
ISO		 MGI:3586988 (MGI:3586399|PMID:16049186) RGD PMID:16049186 PMID:12414813 MGI:3586399, RGD:729117 NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15488758)		 UniProt
RGD		 PMID:15488758 GO_REF:0000024 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2447085|PMID:12482708)
GO_REF:0000107		 RGD
Ensembl		 PMID:12482708 GO_REF:0000107 MGI:2447085 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1933753|PMID:9852579)
GO_REF:0000107		 RGD
Ensembl		 PMID:9852579 GO_REF:0000107 MGI:1933753 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Sort1 sortilin 1 involved_in ISO
IEA		 (PMID:14985763)
GO_REF:0000107		 RGD
Ensembl		 PMID:14985763 GO_REF:0000107 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IMP RGD PMID:15728722 RGD:1581104 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:15546918 RGD:1580675 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Zfyve27 zinc finger FYVE-type containing 27 involved_in IMP
IBA		 PMID:17082457
PMID:21873635		 UniProt
GO_Central		 PMID:17082457 PMID:21873635 RGD:8554602, RGD:13792537 NCBI chr 1:240,979,831...241,003,193
Ensembl chr 1:240,979,842...241,003,193 		JBrowse link
positive regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386 		JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113 		JBrowse link
G Ngf nerve growth factor acts_upstream_of_or_within IDA PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta acts_upstream_of_or_within IMP PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 1:203,527,268...203,535,442
Ensembl chr 1:203,527,270...203,535,416 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 IMP RGD PMID:18768694 RGD:13504749 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
G Tmem108 transmembrane protein 108 involved_in ISO (MGI:5825407|PMID:27605705), (MGI:5825424|PMID:21849472) RGD PMID:21849472 PMID:27605705 MGI:5825407 MGI:5825424 NCBI chr 8:104,066,081...104,360,172
Ensembl chr 8:104,066,078...104,360,094 		JBrowse link
G Wasf1 WASP family member 1 involved_in ISO
IEA		 (MGI:5825407|PMID:27605705)
GO_REF:0000107		 RGD
Ensembl		 PMID:27605705 GO_REF:0000107 MGI:5825407 NCBI chr20:44,325,815...44,372,999
Ensembl chr20:44,325,795...44,372,996 		JBrowse link
regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dok5 docking protein 5 acts_upstream_of_or_within ISO (PMID:23954828) RGD PMID:23954828 NCBI chr 3:159,515,886...159,652,811
Ensembl chr 3:159,515,893...159,652,810 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 acts_upstream_of_or_within ISO MGI:3604561 (MGI:5515840|PMID:24035762) RGD PMID:24035762 MGI:5515840 NCBI chr  X:134,430,677...134,486,747
Ensembl chr  X:134,420,756...134,485,375 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 acts_upstream_of_or_within ISO (MGI:3706258|PMID:17389358) RGD PMID:17389358 MGI:3706258 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Zdhhc17 zinc finger DHHC-type palmitoyltransferase 17 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5775247|PMID:26232532)		 UniProt
Ensembl
RGD		 PMID:26232532 GO_REF:0000024 GO_REF:0000107 MGI:5775247 NCBI chr 7:46,369,963...46,433,691
Ensembl chr 7:46,369,988...46,433,764 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    cellular process 18233
      signal transduction 6999
        cell surface receptor signaling pathway 2798
          neurotrophin signaling pathway 43
            nerve growth factor signaling pathway 13
            neurotrophin TRK receptor signaling pathway + 30
Path 2
Term Annotations click to browse term
  biological_process 19553
    biological regulation 13187
      regulation of biological process 12813
        signaling 7552
          signal transduction 6999
            cell surface receptor signaling pathway 2798
              neurotrophin signaling pathway 43
                nerve growth factor signaling pathway 13
                neurotrophin TRK receptor signaling pathway + 30
paths to the root