ONTOLOGY REPORT - ANNOTATIONS
Term: neurotrophin signaling pathway
Accession: GO:0038179
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Definition: The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms: exact_synonym: neurotrophin receptor signaling pathway
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Cd2ap
CD2-associated protein
acts_upstream_of_or_within
ISO
MGI:2664945 (PMID:27076424)
RGD
PMID:27076424
NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968
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Gfra1
GDNF family receptor alpha 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501
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Ntrk2
neurotrophic receptor tyrosine kinase 2
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
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Ntrk3
neurotrophic receptor tyrosine kinase 3
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 1:141,526,192...141,913,575
Ensembl chr 1:141,542,569...141,913,004
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Agt
angiotensinogen
involved_in
ISO IEA
(PMID:10406457) GO_REF:0000107
RGD Ensembl
PMID:10406457
GO_REF:0000107
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
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Agtr2
angiotensin II receptor, type 2
involved_in
ISO
(PMID:10406457)
RGD
PMID:10406457
NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745
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Ptprf
protein tyrosine phosphatase, receptor type, F
IMP
NGF stimulated neurite outgrowth in PC12 cells
RGD
PMID:10699984
RGD:1642748
NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426
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Spry1
sprouty RTK signaling antagonist 1
acts_upstream_of_or_within
ISO IEA
(PMID:11585837) GO_REF:0000107
RGD Ensembl
PMID:11585837
GO_REF:0000107
NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:122,484,355...122,492,956
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Spry2
sprouty RTK signaling antagonist 2
acts_upstream_of_or_within
ISO IEA
(PMID:11585837) GO_REF:0000107
RGD Ensembl
PMID:11585837
GO_REF:0000107
NCBI chr15:89,106,809...89,111,926
Ensembl chr15:89,103,731...89,115,074
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Bdnf
brain-derived neurotrophic factor
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
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Cd2ap
CD2-associated protein
acts_upstream_of_or_within
ISO
MGI:2664945 (PMID:27076424)
RGD
PMID:27076424
NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968
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Coro1a
coronin 1A
acts_upstream_of_or_within
ISO IEA
MGI:97321|MGI:97383 (PMID:24270184) GO_REF:0000107
RGD Ensembl
PMID:24270184
GO_REF:0000107
NCBI chr 1:190,726,129...190,731,133
Ensembl chr 1:190,726,130...190,731,102
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Kidins220
kinase D-interacting substrate 220
involved_in
IDA IBA
PMID:17724123 GO_REF:0000033
GO_Central
PMID:17724123
GO_REF:0000033, RGD:8554481
NCBI chr 6:47,346,790...47,435,599
Ensembl chr 6:47,346,832...47,431,865
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Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
involved_in
IDA
PMID:17724123
UniProt
PMID:17724123
RGD:8554481
NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:15,278,518...16,762,199
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Ngf
nerve growth factor
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:1345961|MGI:97383 (PMID:24270184), (PMID:7854358)
GO_Central RGD
PMID:7854358 PMID:24270184
GO_REF:0000033
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
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Ntf3
neurotrophin 3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349
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Ntf4
neurotrophin 4
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:105,030,035...105,032,866
Ensembl chr 1:105,029,764...105,034,038
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Ntrk1
neurotrophic receptor tyrosine kinase 1
involved_in acts_upstream_of_or_within
ISO IEA IBA IDA
(PMID:1281417) GO_REF:0000117 GO_REF:0000107 MGI:1345961|MGI:97321 (PMID:24270184), (PMID:7854358) GO_REF:0000033 PMID:17724123
RGD UniProt Ensembl GO_Central
PMID:1281417 PMID:7854358 PMID:24270184 PMID:17724123
GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:8554481
NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787
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Rap1a
RAP1A, member of RAS oncogene family
involved_in
IDA
PMID:17724123
UniProt
PMID:17724123
RGD:8554481
NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808
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Rapgef1
Rap guanine nucleotide exchange factor 1
involved_in
ISO
(PMID:17724123)
RGD
PMID:17724123
NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:33,296,230...33,414,119
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Rapgef2
Rap guanine nucleotide exchange factor 2
involved_in
IDA
PMID:17724123
UniProt
PMID:17724123
RGD:8554481
NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:166,505,868...166,726,698
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Shoc2
SHOC2 leucine-rich repeat scaffold protein
involved_in
IMP IBA
GO_REF:0000033
GO_Central RGD
PMID:25514808
GO_REF:0000033, RGD:155804270
NCBI chr 1:262,964,345...263,052,898
Ensembl chr 1:262,965,011...263,052,634
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Sort1
sortilin 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481
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Akt1s1
AKT1 substrate 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:104,469,803...104,476,167
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Bcar1
BCAR1 scaffold protein, Cas family member
involved_in
IDA
PMID:8631760
UniProt
PMID:8631760
RGD:8553306
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:56,588,500...56,623,190
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Casp3
caspase 3
acts_upstream_of_or_within
ISO IEA
(PMID:23954828) GO_REF:0000107
RGD Ensembl
PMID:23954828
GO_REF:0000107
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Cd2ap
CD2-associated protein
acts_upstream_of_or_within
ISO
MGI:2664945 (PMID:27076424)
RGD
PMID:27076424
NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:25,583,975...25,679,968
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Ddit4
DNA-damage-inducible transcript 4
involved_in
IMP
PMID:21368030
UniProt
PMID:21368030
RGD:8554300
NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
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Hap1
huntingtin-associated protein 1
involved_in
IEA ISO IBA ISS
GO_REF:0000107 (PMID:24355921) GO_REF:0000033 GO_REF:0000024
Ensembl RGD GO_Central UniProt
PMID:24355921
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr10:85,778,267...85,786,553
Ensembl chr10:85,778,267...85,786,503
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Mageh1
MAGE family member H1
NAS
RGD
PMID:12414813
RGD:729117
NCBI chr X:18,350,015...18,351,271
Ensembl chr X:21,718,669...21,727,219
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Ndn
necdin, MAGE family member
acts_upstream_of_or_within
NAS IEA ISO
GO_REF:0000107 MGI:3586988 (PMID:16049186)
Ensembl RGD
PMID:16049186 PMID:12414813
GO_REF:0000107, RGD:729117
NCBI chr 1:125,261,059...125,262,658
Ensembl chr 1:125,260,997...125,262,785
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Ngf
nerve growth factor
involved_in
ISO
(PMID:19036963)
RGD
PMID:19036963
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
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Ntrk1
neurotrophic receptor tyrosine kinase 1
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:15488758)
UniProt Ensembl RGD
PMID:15488758
GO_REF:0000024 GO_REF:0000107
NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
acts_upstream_of_or_within
ISO IEA
(PMID:12482708) GO_REF:0000107
RGD Ensembl
PMID:12482708
GO_REF:0000107
NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
acts_upstream_of_or_within
ISO IEA
(PMID:9852579) GO_REF:0000107
RGD Ensembl
PMID:9852579
GO_REF:0000107
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
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Sort1
sortilin 1
involved_in
ISO IEA
(PMID:14985763) GO_REF:0000107
RGD Ensembl
PMID:14985763
GO_REF:0000107
NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481
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Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
IMP
RGD
PMID:15728722
RGD:1581104
NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
IDA
RGD
PMID:15546918
RGD:1580675
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
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Zfyve27
zinc finger FYVE-type containing 27
involved_in
IMP IBA
PMID:17082457 GO_REF:0000033
GO_Central
PMID:17082457
GO_REF:0000033, RGD:8554602
NCBI chr 1:250,929,110...250,952,481
Ensembl chr 1:250,928,012...250,952,481
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Cyfip1
cytoplasmic FMR1 interacting protein 1
involved_in
ISO
(PMID:27605705)
RGD
PMID:27605705
NCBI chr 1:115,842,754...115,935,163
Ensembl chr 1:115,846,661...115,951,292
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Cyfip2
cytoplasmic FMR1 interacting protein 2
involved_in
ISO IEA
(PMID:27605705) GO_REF:0000107
RGD Ensembl
PMID:27605705
GO_REF:0000107
NCBI chr10:31,122,653...31,242,440
Ensembl chr10:31,122,653...31,242,440
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Ngf
nerve growth factor
acts_upstream_of_or_within
IDA
PMID:19029245
MGI
PMID:19029245
RGD:8553977
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
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Ppp2r5b
protein phosphatase 2, regulatory subunit B', beta
acts_upstream_of_or_within
IMP
PMID:19029245
MGI
PMID:19029245
RGD:8553977
NCBI chr 1:203,527,268...203,535,442
Ensembl chr 1:212,956,533...212,964,662
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Sh3glb1
SH3 domain -containing GRB2-like endophilin B1
IMP
RGD
PMID:18768694
RGD:13504749
NCBI chr 2:236,411,194...236,445,225
Ensembl chr 2:236,410,436...236,445,140
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Tmem108
transmembrane protein 108
involved_in
ISO IEA
(PMID:21849472), (PMID:27605705) GO_REF:0000107
RGD Ensembl
PMID:21849472 PMID:27605705
GO_REF:0000107
NCBI chr 8:112,944,925...113,238,996
Ensembl chr 8:112,944,928...112,984,211
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Wasf1
WASP family member 1
involved_in
IEA ISO
GO_REF:0000107 (PMID:27605705)
Ensembl RGD
PMID:27605705
GO_REF:0000107
NCBI chr20:45,908,458...45,956,118
Ensembl chr20:45,908,750...45,955,640
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Dok5
docking protein 5
acts_upstream_of_or_within
ISO IEA
(PMID:23954828) GO_REF:0000107
RGD Ensembl
PMID:23954828
GO_REF:0000107
NCBI chr 3:159,515,886...159,652,811
Ensembl chr 3:179,934,552...180,071,333
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Slc9a6
solute carrier family 9 member A6
acts_upstream_of_or_within
ISO
MGI:3604561 (PMID:24035762)
RGD
PMID:24035762
NCBI chr X:139,468,045...139,524,111
Ensembl chr X:139,458,127...139,524,109
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Ulk1
unc-51 like autophagy activating kinase 1
acts_upstream_of_or_within
ISO
(PMID:17389358)
RGD
PMID:17389358
NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746
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Zdhhc17
zinc finger DHHC-type palmitoyltransferase 17
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:26232532) GO_REF:0000107
UniProt RGD Ensembl
PMID:26232532
GO_REF:0000024 GO_REF:0000107
NCBI chr 7:48,256,269...48,320,000
Ensembl chr 7:48,257,856...48,320,160
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