ONTOLOGY REPORT - ANNOTATIONS
Term: neurotrophin signaling pathway
Accession: GO:0038179
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Definition: The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms: exact_synonym: neurotrophin receptor signaling pathway
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Gfra1
GDNF family receptor alpha 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
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Ntrk1
neurotrophic receptor tyrosine kinase 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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Ntrk2
neurotrophic receptor tyrosine kinase 2
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Ntrk3
neurotrophic receptor tyrosine kinase 3
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
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Agt
angiotensinogen
involved_in
ISO IEA
(PMID:10406457) GO_REF:0000107
RGD Ensembl
PMID:10406457
GO_REF:0000107
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Agtr2
angiotensin II receptor, type 2
involved_in
ISO
(PMID:10406457)
RGD
PMID:10406457
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Ptprf
protein tyrosine phosphatase, receptor type, F
IMP
NGF stimulated neurite outgrowth in PC12 cells
RGD
PMID:10699984
RGD:1642748
NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
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Spry1
sprouty RTK signaling antagonist 1
acts_upstream_of_or_within
ISO
(MGI:2154590|PMID:11585837)
RGD
PMID:11585837
MGI:2154590
NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189
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Spry2
sprouty RTK signaling antagonist 2
acts_upstream_of_or_within
ISO
(MGI:2154590|PMID:11585837)
RGD
PMID:11585837
MGI:2154590
NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009
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Bdnf
brain-derived neurotrophic factor
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Coro1a
coronin 1A
acts_upstream_of_or_within
ISO
MGI:97321|MGI:97383 (MGI:5559799|PMID:24270184)
RGD
PMID:24270184
MGI:5559799
NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
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Kidins220
kinase D-interacting substrate 220
involved_in
IDA IBA
PMID:17724123 PMID:21873635
UniProt GO_Central
PMID:17724123 PMID:21873635
RGD:8554481 , RGD:13792537
NCBI chr 6:41,618,207...41,706,990
Ensembl chr 6:41,618,294...41,703,256
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Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
involved_in
IDA
PMID:17724123
UniProt
PMID:17724123
RGD:8554481
NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240
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Ngf
nerve growth factor
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 MGI:1345961|MGI:97383 (MGI:5559799|PMID:24270184), (MGI:69378|PMID:7854358)
RGD
PMID:7854358 PMID:24270184 PMID:21873635
MGI:5559799 MGI:69378 , RGD:13792537
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ntf3
neurotrophin 3
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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Ntf4
neurotrophin 4
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243
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Ntrk1
neurotrophic receptor tyrosine kinase 1
involved_in acts_upstream_of_or_within
ISO IDA IBA
(PMID:1281417) MGI:1345961|MGI:97321 (MGI:5559799|PMID:24270184), (MGI:69378|PMID:7854358) PMID:17724123 PMID:21873635
RGD
PMID:1281417 PMID:7854358 PMID:24270184 PMID:17724123 PMID:21873635
MGI:5559799 MGI:69378 , RGD:8554481 , RGD:13792537
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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Rap1a
RAP1A, member of RAS oncogene family
involved_in
IDA
PMID:17724123
UniProt
PMID:17724123
RGD:8554481
NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
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Rapgef1
Rap guanine nucleotide exchange factor 1
involved_in
ISO
(PMID:17724123)
RGD
PMID:17724123
NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984
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Rapgef2
Rap guanine nucleotide exchange factor 2
involved_in
IDA
PMID:17724123
UniProt
PMID:17724123
RGD:8554481
NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247
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Shoc2
SHOC2 leucine-rich repeat scaffold protein
IMP
RGD
PMID:25514808
RGD:155804270
NCBI chr 1:252,958,939...253,048,820
Ensembl chr 1:252,959,723...253,047,337
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Sort1
sortilin 1
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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Akt1s1
AKT1 substrate 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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Bcar1
BCAR1 scaffold protein, Cas family member
involved_in
IDA
PMID:8631760
UniProt
PMID:8631760
RGD:8553306
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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Casp3
caspase 3
acts_upstream_of_or_within
ISO
(PMID:23954828)
RGD
PMID:23954828
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ddit4
DNA-damage-inducible transcript 4
involved_in
IMP
PMID:21368030
UniProt
PMID:21368030
RGD:8554300
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Hap1
huntingtin-associated protein 1
involved_in
IEA ISO ISS IBA
GO_REF:0000107 (MGI:5560429|PMID:24355921) GO_REF:0000024 PMID:21873635
Ensembl RGD UniProt
PMID:24355921 PMID:21873635
GO_REF:0000024 GO_REF:0000107 MGI:5560429 , RGD:13792537
NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
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Mageh1
MAGE family member H1
NAS
RGD
PMID:12414813
RGD:729117
NCBI chr X:18,350,015...18,351,271
Ensembl chr X:18,349,774...18,351,516
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Ndn
necdin, MAGE family member
acts_upstream_of_or_within
NAS ISO
MGI:3586988 (MGI:3586399|PMID:16049186)
RGD
PMID:16049186 PMID:12414813
MGI:3586399 , RGD:729117
NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767
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Ntrk1
neurotrophic receptor tyrosine kinase 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:15488758)
UniProt RGD
PMID:15488758
GO_REF:0000024
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:2447085|PMID:12482708) GO_REF:0000107
RGD Ensembl
PMID:12482708
GO_REF:0000107 MGI:2447085
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
acts_upstream_of_or_within involved_in
ISO IEA
(MGI:1933753|PMID:9852579) GO_REF:0000107
RGD Ensembl
PMID:9852579
GO_REF:0000107 MGI:1933753
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Sort1
sortilin 1
involved_in
ISO IEA
(PMID:14985763) GO_REF:0000107
RGD Ensembl
PMID:14985763
GO_REF:0000107
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
IMP
RGD
PMID:15728722
RGD:1581104
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
IDA
RGD
PMID:15546918
RGD:1580675
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Zfyve27
zinc finger FYVE-type containing 27
involved_in
IMP IBA
PMID:17082457 PMID:21873635
UniProt GO_Central
PMID:17082457 PMID:21873635
RGD:8554602 , RGD:13792537
NCBI chr 1:240,979,831...241,003,193
Ensembl chr 1:240,979,842...241,003,193
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Cyfip1
cytoplasmic FMR1 interacting protein 1
involved_in
ISO
(MGI:5825407|PMID:27605705)
RGD
PMID:27605705
MGI:5825407
NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386
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Cyfip2
cytoplasmic FMR1 interacting protein 2
involved_in
ISO
(MGI:5825407|PMID:27605705)
RGD
PMID:27605705
MGI:5825407
NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113
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Ngf
nerve growth factor
acts_upstream_of_or_within
IDA
PMID:19029245
MGI
PMID:19029245
RGD:8553977
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ppp2r5b
protein phosphatase 2, regulatory subunit B', beta
acts_upstream_of_or_within
IMP
PMID:19029245
MGI
PMID:19029245
RGD:8553977
NCBI chr 1:203,527,268...203,535,442
Ensembl chr 1:203,527,270...203,535,416
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Sh3glb1
SH3 domain -containing GRB2-like endophilin B1
IMP
RGD
PMID:18768694
RGD:13504749
NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784
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Tmem108
transmembrane protein 108
involved_in
ISO
(MGI:5825407|PMID:27605705), (MGI:5825424|PMID:21849472)
RGD
PMID:21849472 PMID:27605705
MGI:5825407 MGI:5825424
NCBI chr 8:104,066,081...104,360,172
Ensembl chr 8:104,066,078...104,360,094
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Wasf1
WASP family member 1
involved_in
ISO IEA
(MGI:5825407|PMID:27605705) GO_REF:0000107
RGD Ensembl
PMID:27605705
GO_REF:0000107 MGI:5825407
NCBI chr20:44,325,815...44,372,999
Ensembl chr20:44,325,795...44,372,996
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Dok5
docking protein 5
acts_upstream_of_or_within
ISO
(PMID:23954828)
RGD
PMID:23954828
NCBI chr 3:159,515,886...159,652,811
Ensembl chr 3:159,515,893...159,652,810
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Slc9a6
solute carrier family 9 member A6
acts_upstream_of_or_within
ISO
MGI:3604561 (MGI:5515840|PMID:24035762)
RGD
PMID:24035762
MGI:5515840
NCBI chr X:134,430,677...134,486,747
Ensembl chr X:134,420,756...134,485,375
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Ulk1
unc-51 like autophagy activating kinase 1
acts_upstream_of_or_within
ISO
(MGI:3706258|PMID:17389358)
RGD
PMID:17389358
MGI:3706258
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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Zdhhc17
zinc finger DHHC-type palmitoyltransferase 17
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (MGI:5775247|PMID:26232532)
UniProt Ensembl RGD
PMID:26232532
GO_REF:0000024 GO_REF:0000107 MGI:5775247
NCBI chr 7:46,369,963...46,433,691
Ensembl chr 7:46,369,988...46,433,764
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