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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin signaling pathway
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Accession:GO:0038179 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment:There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms:exact_synonym: neurotrophin receptor signaling pathway


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neurotrophin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfra1 GDNF family receptor alpha 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:257,315,682...257,552,004 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:173,236,961...173,253,806 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:5,558,992...5,870,299 JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:132,116,472...132,503,849 JBrowse link
negative regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr2 angiotensin II receptor, type 2 involved_in ISO (PMID:10406457) RGD PMID:10406457 NCBI chr  X:112,119,673...112,124,060 JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP NGF stimulated neurite outgrowth in PC12 cells RGD PMID:10699984 RGD:1642748 NCBI chr 5:131,741,959...131,824,000 JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr 2:120,557,276...120,561,918 JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (MGI:2154590|PMID:11585837) RGD PMID:11585837 MGI:2154590 NCBI chr15:82,692,312...82,697,408 JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:96,165,042...96,215,621 JBrowse link
G Coro1a coronin 1A acts_upstream_of_or_within ISO MGI:97321|MGI:97383 (MGI:5559799|PMID:24270184) RGD PMID:24270184 MGI:5559799 NCBI chr 1:181,295,561...181,300,566 JBrowse link
G Kidins220 kinase D-interacting substrate 220 involved_in IDA
IBA
PMID:17724123
PMID:21873635
UniProt
GO_Central
PMID:17724123, PMID:21873635 RGD:8554481, RGD:13792537 NCBI chr 6:41,618,207...41,706,990 JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 4:14,388,322...15,870,036 JBrowse link
G Ngf nerve growth factor involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1345961|MGI:97383 (MGI:5559799|PMID:24270184), (MGI:69378|PMID:7854358)
RGD PMID:7854358 PMID:24270184, PMID:21873635 MGI:5559799 MGI:69378, RGD:13792537 NCBI chr 2:189,901,058...189,954,452 JBrowse link
G Ntf3 neurotrophin 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:158,914,984...158,984,453 JBrowse link
G Ntf4 neurotrophin 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:95,893,560...95,896,391 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within
ISO
IDA
IBA
(PMID:1281417)
MGI:1345961|MGI:97321 (MGI:5559799|PMID:24270184), (MGI:69378|PMID:7854358)
PMID:17724123
PMID:21873635
RGD PMID:1281417 PMID:7854358 PMID:24270184, PMID:17724123, PMID:21873635 MGI:5559799 MGI:69378, RGD:8554481, RGD:13792537 NCBI chr 2:173,236,961...173,253,806 JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 2:193,208,631...193,286,513 JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:17724123) RGD PMID:17724123 NCBI chr 3:12,898,349...13,016,234 JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 involved_in IDA PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr 2:164,207,513...164,322,157 JBrowse link
G Sort1 sortilin 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:195,924,033...196,002,354 JBrowse link
neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:95,333,186...95,339,678 JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in IDA PMID:8631760 UniProt PMID:8631760 RGD:8553306 NCBI chr19:39,679,218...39,713,952 JBrowse link
G Bex1 brain expressed, X-linked 1 acts_upstream_of_or_within IGI PMID:16498402 MGI PMID:16498402 RGD:8554704 NCBI chr  X:99,219,015...99,220,411 JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO (PMID:23954828) RGD PMID:23954828 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in IMP PMID:21368030 UniProt PMID:21368030 RGD:8554300 NCBI chr20:27,891,989...27,894,088 JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IEA
ISO
ISS
IBA
GO_REF:0000107
(MGI:5560429|PMID:24355921)
GO_REF:0000024
PMID:21873635
Ensembl
RGD
UniProt
PMID:24355921, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5560429, RGD:13792537 NCBI chr10:85,277,890...85,286,126 JBrowse link
G Mageh1 MAGE family member H1 NAS RGD PMID:12414813 RGD:729117 NCBI chr  X:18,350,015...18,351,271 JBrowse link
G Ndn necdin, MAGE family member acts_upstream_of_or_within NAS
ISO
MGI:3586988 (MGI:3586399|PMID:16049186) RGD PMID:16049186, PMID:12414813 MGI:3586399, RGD:729117 NCBI chr 1:115,849,168...115,850,767 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:15488758)
UniProt
RGD
PMID:15488758 GO_REF:0000024 NCBI chr 2:173,236,961...173,253,806 JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO (MGI:2447085|PMID:12482708) RGD PMID:12482708 MGI:2447085 NCBI chr12:35,365,436...35,424,925 JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (MGI:1933753|PMID:9852579) RGD PMID:9852579 MGI:1933753 NCBI chr 4:148,679,534...148,740,265 JBrowse link
G Sort1 sortilin 1 involved_in ISO (PMID:14985763) RGD PMID:14985763 NCBI chr 2:195,924,033...196,002,354 JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IMP RGD PMID:15728722 RGD:1581104 NCBI chr 6:14,533,870...14,613,348 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:15546918 RGD:1580675 NCBI chr 3:146,091,969...146,139,492 JBrowse link
G Zfyve27 zinc finger FYVE-type containing 27 involved_in IBA
IMP
PMID:21873635
PMID:17082457
GO_Central
UniProt
PMID:21873635, PMID:17082457 RGD:13792537, RGD:8554602 NCBI chr 1:240,979,831...241,003,193 JBrowse link
positive regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr 1:106,710,924...106,799,393 JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr10:30,621,318...30,741,113 JBrowse link
G Ngf nerve growth factor acts_upstream_of_or_within IDA PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 2:189,901,058...189,954,452 JBrowse link
G Ppp2r5b protein phosphatase 2, regulatory subunit B', beta acts_upstream_of_or_within IMP PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr 1:203,527,268...203,535,442 JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 IMP RGD PMID:18768694 RGD:13504749 NCBI chr 2:233,750,838...233,784,817 JBrowse link
G Tmem108 transmembrane protein 108 involved_in ISO (MGI:5825407|PMID:27605705), (MGI:5825424|PMID:21849472) RGD PMID:21849472 PMID:27605705 MGI:5825407 MGI:5825424 NCBI chr 8:104,066,081...104,360,172 JBrowse link
G Wasf1 WASP family member 1 involved_in ISO (MGI:5825407|PMID:27605705) RGD PMID:27605705 MGI:5825407 NCBI chr20:44,325,815...44,372,999 JBrowse link
regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dok5 docking protein 5 acts_upstream_of_or_within ISO (PMID:23954828) RGD PMID:23954828 NCBI chr 3:159,515,886...159,652,811 JBrowse link
G Slc9a6 solute carrier family 9 member A6 acts_upstream_of_or_within ISO MGI:3604561 (MGI:5515840|PMID:24035762) RGD PMID:24035762 MGI:5515840 NCBI chr  X:134,430,588...134,486,747 JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 acts_upstream_of_or_within ISO (MGI:3706258|PMID:17389358) RGD PMID:17389358 MGI:3706258 NCBI chr12:45,851,710...45,877,966 JBrowse link
G Zdhhc17 zinc finger DHHC-type palmitoyltransferase 17 involved_in ISS
ISO
GO_REF:0000024
(MGI:5775247|PMID:26232532)
UniProt
RGD
PMID:26232532 GO_REF:0000024 MGI:5775247 NCBI chr 7:46,369,963...46,433,691 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    signaling 7457
      signal transduction 6880
        cell surface receptor signaling pathway 2778
          neurotrophin signaling pathway 43
            nerve growth factor signaling pathway 12
            neurotrophin TRK receptor signaling pathway + 31
Path 2
Term Annotations click to browse term
  biological_process 19492
    response to stimulus 10355
      response to chemical 6185
        response to organic substance 3888
          cellular response to organic substance 2868
            cellular response to growth factor stimulus 780
              neurotrophin signaling pathway 43
                nerve growth factor signaling pathway 12
                neurotrophin TRK receptor signaling pathway + 31
paths to the root