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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:ERBB2 signaling pathway
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Accession:GO:0038128 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
Synonyms:exact_synonym: ERBB2 signalling pathway;   HER2 signaling pathway;   NEU signaling;   receptor tyrosine-protein kinase erbB-2 signaling pathway


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ERBB2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpne3 copine 3 involved_in ISO
IBA		 (PMID:20010870)
GO_REF:0000033		 RGD
GO_Central		 PMID:20010870 GO_REF:0000033 NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934 		JBrowse link
G Ptprr protein tyrosine phosphatase, receptor type, R involved_in IEA
ISO		 GO_REF:0000107
(PMID:21724833)		 Ensembl
RGD		 PMID:21724833 GO_REF:0000107 NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603 		JBrowse link
ERBB2-EGFR signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin involved_in ISO (PMID:8702723) RGD PMID:8702723 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Btc betacellulin involved_in ISO (PMID:21897861) RGD PMID:21897861 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Egf epidermal growth factor involved_in ISO
IEA		 (PMID:11336639)
(PMID:22822073)
GO_REF:0000107		 RGD
Ensembl		 PMID:11336639 PMID:22822073 GO_REF:0000107 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (PMID:11336639)
MGI:1856402 (PMID:18701712), (PMID:21897861), (PMID:21946538), (PMID:8702723), (PMID:9556621)		 RGD PMID:8702723 PMID:9556621 PMID:11336639 PMID:18701712 PMID:21897861 More... NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in ISO
IEA		 (PMID:8702723)
MGI:95294 (PMID:16357442), (PMID:18701712), (PMID:21897861), (PMID:8702723), (PMID:9556621)
GO_REF:0000107		 RGD
Ensembl		 PMID:8702723 PMID:9556621 PMID:16357442 PMID:18701712 PMID:21897861 GO_REF:0000107 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Ereg epiregulin involved_in ISO (PMID:9556621) RGD PMID:9556621 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor involved_in ISO MGI:2665039 (PMID:21946538) RGD PMID:21946538 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Tgfa transforming growth factor alpha involved_in ISO
IEA		 (PMID:8702723)
GO_REF:0000107		 RGD
Ensembl		 PMID:8702723 GO_REF:0000107 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
ERBB2-ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in IEA
ISO		 GO_REF:0000107
MGI:1929070|MGI:2177256 (PMID:10399934), (PMID:10704452), (PMID:8702723), (PMID:9742126)		 Ensembl
RGD		 PMID:8702723 PMID:9742126 PMID:10399934 PMID:10704452 GO_REF:0000107 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 involved_in IEA
ISO		 GO_REF:0000107
MGI:1929598 (PMID:18760695), (PMID:8702723), (PMID:9742126)		 Ensembl
RGD		 PMID:8702723 PMID:9742126 PMID:18760695 GO_REF:0000107 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24493648)		 Ensembl
RGD		 PMID:24493648 GO_REF:0000107 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24493648)		 Ensembl
RGD		 PMID:24493648 GO_REF:0000107 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24493648)		 Ensembl
RGD		 PMID:24493648 GO_REF:0000107 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 involved_in ISO (PMID:24493648) RGD PMID:24493648 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myoc myocilin involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5527213|PMID:23897819)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23897819 GO_REF:0000024 GO_REF:0000107 MGI:5527213 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127 		JBrowse link
G Nrg1 neuregulin 1 involved_in ISO
IEA		 (PMID:8702723)
MGI:1928489|MGI:2448075 (PMID:18760695), (PMID:21220101), (PMID:30535360), (PMID:7477375)
GO_REF:0000107		 RGD
Ensembl		 PMID:7477375 PMID:8702723 PMID:18760695 PMID:21220101 PMID:30535360 GO_REF:0000107 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Nrg2 neuregulin 2 involved_in ISO (PMID:9742126) RGD PMID:9742126 NCBI chr18:27,616,542...27,798,505
Ensembl chr18:27,619,661...27,798,505 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase involved_in IEA
ISO		 GO_REF:0000107
(PMID:24493648)		 Ensembl
RGD		 PMID:24493648 GO_REF:0000107 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
ERBB2-ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in IDA
IEA
ISO		 PMID:19632177
GO_REF:0000107
MGI:104771 (PMID:12621152), (PMID:9556621)		 Ensembl
RGD		 PMID:9556621 PMID:12621152 PMID:19632177 GO_REF:0000107, RGD:11251908 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in IEA
ISO		 GO_REF:0000107
MGI:95410 (PMID:12621152), (PMID:8702723), (PMID:9556621)		 Ensembl
RGD		 PMID:8702723 PMID:9556621 PMID:12621152 GO_REF:0000107 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ereg epiregulin involved_in ISO (PMID:9556621) RGD PMID:9556621 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor involved_in ISO MGI:2655703 (PMID:12621152) RGD PMID:12621152 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Nrg1 neuregulin 1 involved_in ISO
IEA		 (PMID:19632177)
GO_REF:0000107		 RGD
Ensembl		 PMID:19632177 GO_REF:0000107 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      signal transduction 7163
        cell surface receptor signaling pathway 2879
          enzyme-linked receptor protein signaling pathway 1052
            cell surface receptor protein tyrosine kinase signaling pathway 664
              ERBB signaling pathway 131
                ERBB2 signaling pathway 20
                  ERBB2-EGFR signaling pathway 8
                  ERBB2-ERBB3 signaling pathway 10
                  ERBB2-ERBB4 signaling pathway 5
Path 2
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13633
      regulation of biological process 13220
        signaling 7729
          signal transduction 7163
            cell surface receptor signaling pathway 2879
              enzyme-linked receptor protein signaling pathway 1052
                cell surface receptor protein tyrosine kinase signaling pathway 664
                  ERBB signaling pathway 131
                    ERBB2 signaling pathway 20
                      ERBB2-EGFR signaling pathway 8
                      ERBB2-ERBB3 signaling pathway 10
                      ERBB2-ERBB4 signaling pathway 5
paths to the root