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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:nodal signaling pathway
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Accession:GO:0038092 term browser browse the term
Definition:The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: nodal signaling;   nodal signalling pathway


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nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1B activin A receptor type 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:36,765,655...36,811,355
Ensembl chr12:37,541,867...37,566,660 		JBrowse link
G ACVR1C activin A receptor type 1C involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:44,785,808...44,883,977
Ensembl chr2B:162,034,161...162,124,151 		JBrowse link
G CFC1B cryptic, EGF-CFC family member 1B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:29,354,004...29,362,161 JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 involved_in ISO (MGI:3054669|PMID:15475956) BHF-UCL PMID:15475956 MGI:3054669 NCBI chr 6:137,134,142...137,136,550 JBrowse link
G CRIPTO cripto, EGF-CFC family member involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:46,473,282...46,478,454
Ensembl chr 3:47,577,949...47,583,126 		JBrowse link
G CRIPTO3 cripto, EGF-CFC family member 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:99,628,286...99,629,441
Ensembl chr  X:110,098,995...110,099,538 		JBrowse link
G NODAL nodal growth differentiation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:66,906,866...66,916,938
Ensembl chr10:69,433,959...69,443,972 		JBrowse link
G NOG noggin involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:50,669,186...50,671,081
Ensembl chr17:55,532,394...55,533,092 		JBrowse link
G SMAD2 SMAD family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:41,213,001...41,309,902
Ensembl chr18:44,580,905...44,668,530 		JBrowse link
G SMAD3 SMAD family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:46,013,764...46,143,126
Ensembl chr15:64,284,949...64,414,185 		JBrowse link
G TGIF1 TGFB induced factor homeobox 1 acts_upstream_of_or_within ISO (PMID:20040491) MGI PMID:20040491 NCBI chr18:10,819,015...10,830,282
Ensembl chr18:13,128,359...13,139,145 		JBrowse link
G TGIF2 TGFB induced factor homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20040491) Ensembl
MGI		 PMID:20040491 GO_REF:0000107 NCBI chr20:32,906,641...32,927,119
Ensembl chr20:34,028,415...34,046,354 		JBrowse link
G ZIC2 Zic family member 2 acts_upstream_of_or_within ISO (PMID:24585447) MGI PMID:24585447 NCBI chr13:81,151,669...81,156,648 JBrowse link
negative regulation of nodal receptor complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100969502 left-right determination factor 1 involved_in ISO (MGI:3042530|PMID:15062104) UniProt PMID:15062104 MGI:3042530 NCBI chr 1:201,347,411...201,351,295
Ensembl chr 1:206,348,419...206,350,787 		JBrowse link
negative regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DACT2 dishevelled binding antagonist of beta catenin 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:166,295,983...166,308,361
Ensembl chr 6:171,237,795...171,247,797
Ensembl chr 6:171,237,795...171,247,797 		JBrowse link
G DAND5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) BHF-UCL PMID:15466485 MGI:3055649 NCBI chr19:12,529,830...12,536,052 JBrowse link
G LOC100969502 left-right determination factor 1 involved_in ISO (MGI:3042530|PMID:15062104) UniProt PMID:15062104 MGI:3042530 NCBI chr 1:201,347,411...201,351,295
Ensembl chr 1:206,348,419...206,350,787 		JBrowse link
regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DACT1 dishevelled binding antagonist of beta catenin 1 NOT|involved_in ISO (PMID:17197390)
(MGI:5437437|PMID:17197390)		 UniProt PMID:17197390 MGI:5437437 NCBI chr14:39,231,910...39,242,353
Ensembl chr14:57,499,906...57,510,019 		JBrowse link
G DMRT1 doublesex and mab-3 related transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23473982) Ensembl
MGI		 PMID:23473982 GO_REF:0000107 NCBI chr 9:650,678...778,519
Ensembl chr 9:844,366...972,656 		JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAND5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) BHF-UCL PMID:15466485 MGI:3055649 NCBI chr19:12,529,830...12,536,052 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    cellular process 15499
      signal transduction 5440
        cell surface receptor signaling pathway 2631
          enzyme-linked receptor protein signaling pathway 947
            cell surface receptor protein serine/threonine kinase signaling pathway 365
              transforming growth factor beta receptor superfamily signaling pathway 343
                activin receptor signaling pathway 50
                  nodal signaling pathway 18
                    negative regulation of nodal signaling pathway + 3
                    nodal receptor complex assembly + 1
                    positive regulation of nodal signaling pathway 0
                    regulation of nodal signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 16440
    biological regulation 11453
      regulation of biological process 11104
        signaling 5935
          signal transduction 5440
            cell surface receptor signaling pathway 2631
              enzyme-linked receptor protein signaling pathway 947
                cell surface receptor protein serine/threonine kinase signaling pathway 365
                  transforming growth factor beta receptor superfamily signaling pathway 343
                    activin receptor signaling pathway 50
                      nodal signaling pathway 18
                        negative regulation of nodal signaling pathway + 3
                        nodal receptor complex assembly + 1
                        positive regulation of nodal signaling pathway 0
                        regulation of nodal signaling pathway + 5
paths to the root