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ONTOLOGY REPORT - ANNOTATIONS


Term:nodal signaling pathway
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Accession:GO:0038092 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: nodal signaling;   nodal signalling pathway



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nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor type 1B involved_in ISO UniProtKB:P43021 (PMID:11389842) RGD PMID:11389842 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673
JBrowse link
G Acvr1c activin A receptor type 1C involved_in ISO
IEA
(PMID:15150278)
GO_REF:0000107
RGD
Ensembl
PMID:15150278 GO_REF:0000107 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327
JBrowse link
G Cfc1 cripto, FRL-1, cryptic family 1 involved_in IBA
ISO
PMID:21873635
(MGI:5318034|PMID:12052855)
RGD PMID:12052855 PMID:21873635 MGI:5318034, RGD:13792537 NCBI chr 9:36,742,106...36,751,931
Ensembl chr 9:36,739,071...36,751,930
JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (MGI:5318034|PMID:12052855) RGD PMID:12052855 MGI:5318034 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837
JBrowse link
G Smad2 SMAD family member 2 involved_in ISO (PMID:15150278) RGD PMID:15150278 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:15150278) RGD PMID:15150278 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 involved_in IBA
ISO
PMID:21873635
UniProtKB:P43021 (MGI:5318034|PMID:12052855), (MGI:5447629|PMID:11389842)
RGD PMID:11389842 PMID:12052855 PMID:21873635 MGI:5318034 MGI:5447629, RGD:13792537 NCBI chr 8:110,924,774...110,938,545
Ensembl chr 8:110,925,024...110,930,308
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 acts_upstream_of_or_within ISO MGI:1915299 (MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:4430444 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
JBrowse link
G Tgif2 TGFB-induced factor homeobox 2 acts_upstream_of_or_within ISO MGI:1194497 (MGI:4430444|PMID:20040491) RGD PMID:20040491 MGI:4430444 NCBI chr 3:145,333,152...145,348,599
Ensembl chr 3:145,333,418...145,348,596
JBrowse link
negative regulation of nodal receptor complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lefty1 left right determination factor 1 involved_in ISO (MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:3042530 NCBI chr13:92,649,226...92,659,722
Ensembl chr13:92,656,323...92,659,720
JBrowse link
negative regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact2 dishevelled-binding antagonist of beta-catenin 2 involved_in IBA
ISO
PMID:21873635
(MGI:3809364|PMID:18716284), (MGI:5437437|PMID:17197390)
RGD PMID:17197390 PMID:18716284 PMID:21873635 MGI:3809364 MGI:5437437, RGD:13792537 NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:3055649 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589
JBrowse link
G Lefty1 left right determination factor 1 involved_in ISO (MGI:3042530|PMID:15062104) RGD PMID:15062104 MGI:3042530 NCBI chr13:92,649,226...92,659,722
Ensembl chr13:92,656,323...92,659,720
JBrowse link
negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589
JBrowse link
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 involved_in ISO (MGI:3054669|PMID:15475956) RGD PMID:15475956 MGI:3054669 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (MGI:5315339|PMID:17507406) RGD PMID:17507406 MGI:5315339 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837
JBrowse link
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 involved_in ISO (PMID:17239842) RGD PMID:17239842 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Zic2 Zic family member 2 acts_upstream_of_or_within ISO MGI:1862004 (MGI:5584215|PMID:24585447) RGD PMID:24585447 MGI:5584215 NCBI chr15:99,576,697...99,581,522
Ensembl chr15:99,576,697...99,581,522
JBrowse link
regulation of nodal signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dact1 dishevelled-binding antagonist of beta-catenin 1 NOT|involved_in ISO (PMID:17197390)
(MGI:5437437|PMID:17197390)
RGD PMID:17197390 MGI:5437437 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 acts_upstream_of_or_within ISO (MGI:5487845|PMID:23473982) RGD PMID:23473982 MGI:5487845 NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333
JBrowse link
sequestering of nodal from receptor via nodal binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dand5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:3055649 NCBI chr19:23,330,917...23,340,486
Ensembl chr19:23,334,164...23,339,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    signaling 7540
      signal transduction 6952
        cell surface receptor signaling pathway 2819
          enzyme linked receptor protein signaling pathway 989
            transmembrane receptor protein serine/threonine kinase signaling pathway 395
              activin receptor signaling pathway 46
                nodal signaling pathway 17
                  negative regulation of nodal signaling pathway + 4
                  nodal receptor complex assembly + 1
                  nodal signaling pathway involved in determination of left/right asymmetry + 6
                  regulation of nodal signaling pathway + 8
Path 2
Term Annotations click to browse term
  biological_process 19512
    biological regulation 13616
      regulation of biological process 12887
        regulation of cellular process 12364
          signal transduction 6952
            cell surface receptor signaling pathway 2819
              enzyme linked receptor protein signaling pathway 989
                transmembrane receptor protein serine/threonine kinase signaling pathway 395
                  activin receptor signaling pathway 46
                    nodal signaling pathway 17
                      negative regulation of nodal signaling pathway + 4
                      nodal receptor complex assembly + 1
                      nodal signaling pathway involved in determination of left/right asymmetry + 6
                      regulation of nodal signaling pathway + 8
paths to the root