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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:vascular endothelial growth factor signaling pathway
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Accession:GO:0038084 term browser browse the term
Definition:The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Comment:In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
Synonyms:exact_synonym: VEGF signaling;   VEGF-activated signaling pathway;   vascular endothelial growth factor signalling pathway
 only_in_taxon: NCBITaxon:7742 ! Vertebrata


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vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT1 fms related receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264 		JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr 2:78,076,008...78,115,137
Ensembl chr 2:78,076,080...78,115,126 		JBrowse link
G FOXC1 forkhead box C1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:837,088...840,593
Ensembl chr 7:837,171...838,805 		JBrowse link
G GAB1 GRB2 associated binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:84,257,958...84,391,511
Ensembl chr 8:84,257,965...84,391,621 		JBrowse link
G KDR kinase insert domain receptor involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G MIR26A microRNA mir-26a involved_in ISO (PMID:28602162) BHF-UCL PMID:28602162 NCBI chr 5:23,112,744...23,112,827
Ensembl chr 5:23,112,744...23,112,827 		JBrowse link
G MYO1C myosin IC involved_in ISO (PMID:23262137) UniProt PMID:23262137 NCBI chr12:47,691,252...47,715,670
Ensembl chr12:47,691,256...47,718,337 		JBrowse link
G NRP1 neuropilin 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr10:56,280,673...56,430,832
Ensembl chr10:56,280,665...56,430,777 		JBrowse link
G NRP2 neuropilin 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:108,974,246...109,092,316
Ensembl chr15:108,974,816...109,092,305 		JBrowse link
G NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:44,156,771...44,186,224
Ensembl chr 1:44,156,778...44,186,194 		JBrowse link
G PGF placental growth factor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:98,149,510...98,162,784
Ensembl chr 7:98,148,994...98,162,741 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta involved_in ISO (PMID:31915155) BHF-UCL PMID:31915155 NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,084,742 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
G VEGFB vascular endothelial growth factor B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:7,872,873...7,876,149
Ensembl chr 2:7,872,870...7,876,118 		JBrowse link
G VEGFC vascular endothelial growth factor C involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr15:39,037,764...39,136,234
Ensembl chr15:39,039,311...39,132,936 		JBrowse link
G VEGFC vascular endothelial growth factor C involved_in IEA TreeGrafter GO_REF:0000118
G VEGFD vascular endothelial growth factor D involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:11,893,254...11,933,923
Ensembl chr  X:11,893,259...11,933,809 		JBrowse link
negative regulation of vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRA2 adhesion G protein-coupled receptor A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21421844) Ensembl
MGI		 PMID:21421844 GO_REF:0000107 NCBI chr15:48,572,953...48,611,034
Ensembl chr15:48,573,197...48,610,668 		JBrowse link
G CADM4 cell adhesion molecule 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:50,462,439...50,478,409
Ensembl chr 6:50,462,450...50,478,383 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,660...261,859,022 		JBrowse link
G DCN decorin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr 5:91,678,601...91,713,925
Ensembl chr 5:91,682,658...91,714,235 		JBrowse link
G EMILIN1 elastin microfibril interfacer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:112,031,910...112,039,928
Ensembl chr 3:112,031,917...112,046,429 		JBrowse link
G HRG histidine rich glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:124,505,305...124,516,387
Ensembl chr13:124,505,312...124,516,705 		JBrowse link
G IL12A interleukin 12A acts_upstream_of
involved_in		 ISO
IEA		 (PMID:30106099) ARUK-UCL
Ensembl		 PMID:30106099 GO_REF:0000107 NCBI chr13:99,733,394...99,741,078
Ensembl chr13:99,733,394...99,741,078 		JBrowse link
G IL12B interleukin 12B acts_upstream_of ISO (PMID:30106099) ARUK-UCL PMID:30106099 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929 		JBrowse link
G MIR16-1 microRNA mir-16-1 involved_in
acts_upstream_of		 ISO (PMID:21885851)
(PMID:23083510)		 BHF-UCL
ARUK-UCL		 PMID:21885851 PMID:23083510 NCBI chr13:100,083,329...100,083,405
Ensembl chr13:100,083,329...100,083,405 		JBrowse link
G MIR16-2 microRNA mir-16-2 involved_in
acts_upstream_of		 ISO (PMID:21885851)
(PMID:23083510)		 BHF-UCL
ARUK-UCL		 PMID:21885851 PMID:23083510 NCBI chr11:17,757,606...17,757,684
Ensembl chr11:17,757,601...17,757,687 		JBrowse link
G MIR199A-1 microRNA mir-199a-1 acts_upstream_of ISO (PMID:28358369) BHF-UCL PMID:28358369 NCBI chr 9:114,533,783...114,533,858
Ensembl chr 9:114,533,777...114,533,880 		JBrowse link
G MIR199A-2 microRNA mir-199a-2 acts_upstream_of ISO (PMID:28358369) BHF-UCL PMID:28358369 NCBI chr 2:69,558,051...69,558,130
Ensembl chr 2:69,558,050...69,558,131 		JBrowse link
G MIR199B microRNA mir-199b acts_upstream_of ISO (PMID:28358369) BHF-UCL PMID:28358369 NCBI chr 1:268,691,520...268,691,593
Ensembl chr 1:268,691,502...268,691,610 		JBrowse link
G MIR342 microRNA mir-342 involved_in ISO (PMID:26857067) BHF-UCL PMID:26857067 NCBI chr 7:121,021,761...121,021,840
Ensembl chr 7:121,021,761...121,021,840 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:79,427,033...79,610,840
Ensembl chr13:79,425,835...79,610,840 		JBrowse link
G SEMA6A semaphorin 6A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:120,560,095...120,687,597
Ensembl chr 2:120,560,099...120,687,106 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:52,153,695...52,158,766
Ensembl chr11:52,153,704...52,159,156 		JBrowse link
G XDH xanthine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
positive regulation of cell migration by vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYO1C myosin IC involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:47,691,252...47,715,670
Ensembl chr12:47,691,256...47,718,337 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:70,026,254...70,086,950
Ensembl chr 6:70,026,373...70,084,742 		JBrowse link
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFRA platelet derived growth factor receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:40,966,568...41,021,440
Ensembl chr 8:40,967,493...41,021,441 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:151,155,753...151,192,818
Ensembl chr 2:151,155,756...151,192,647 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPB1 heat shock protein family B (small) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,949...10,039,704 		JBrowse link
G KDR kinase insert domain receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G PRKD1 protein kinase D1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:69,527,743...69,872,374
Ensembl chr 7:69,527,811...69,872,863 		JBrowse link
G PRKD2 protein kinase D2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:52,559,066...52,599,174
Ensembl chr 6:52,559,393...52,599,132 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
positive regulation of vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:68,675,067...68,948,537
Ensembl chr 8:68,675,070...68,948,414 		JBrowse link
G CCBE1 collagen and calcium binding EGF domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:161,320,627...161,556,539
Ensembl chr 1:161,321,273...161,556,537 		JBrowse link
G ITGB1 integrin subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326 		JBrowse link
G JCAD junctional cadherin 5 associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:40,910,563...40,996,336
Ensembl chr10:40,910,548...40,997,071 		JBrowse link
G MIR21 microRNA mir-21 acts_upstream_of ISO (PMID:30106099) ARUK-UCL PMID:30106099 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MYO1C myosin IC involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:47,691,252...47,715,670
Ensembl chr12:47,691,256...47,718,337 		JBrowse link
G ROBO1 roundabout guidance receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:175,348,223...176,479,482
Ensembl chr13:175,348,410...176,479,481 		JBrowse link
G SMOC2 SPARC related modular calcium binding 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:1,193,163...1,332,739
Ensembl chr 1:1,193,167...1,332,694 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
regulation of vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD63 CD63 molecule involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:21,172,275...21,176,225
Ensembl chr 5:21,172,283...21,176,232 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:198,815...211,346
Ensembl chr 1:199,358...211,346 		JBrowse link
G PTP4A3 protein tyrosine phosphatase 4A3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24403062) Ensembl
MGI		 PMID:24403062 GO_REF:0000107 NCBI chr 4:2,345,119...2,376,765
Ensembl chr 4:2,345,118...2,364,672 		JBrowse link
G TCF4 transcription factor 4 acts_upstream_of_or_within ISO (PMID:20231428) MGI PMID:20231428 NCBI chr 1:104,718,809...105,079,919
Ensembl chr 1:104,719,151...105,079,919 		JBrowse link
G TSPAN16 tetraspanin 16 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:69,999,179...70,015,489
Ensembl chr 2:69,999,118...70,014,753 		JBrowse link
VEGF-activated neuropilin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRP1 neuropilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:56,280,673...56,430,832
Ensembl chr10:56,280,665...56,430,777 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in ISO (PMID:24863063)
(MGI:5287519|PMID:21828096)
(MGI:5141569|PMID:21658587)		 BHF-UCL PMID:21658587 PMID:21828096 PMID:24863063 MGI:5141569 MGI:5287519 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    response to stimulus 10058
      response to endogenous stimulus 2127
        cellular response to endogenous stimulus 1701
          cellular response to growth factor stimulus 863
            cellular response to vascular endothelial growth factor stimulus 80
              vascular endothelial growth factor signaling pathway 54
                VEGF-activated neuropilin signaling pathway + 2
                VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                negative regulation of vascular endothelial growth factor signaling pathway 18
                positive regulation of cell migration by vascular endothelial growth factor signaling pathway + 7
                positive regulation of vascular endothelial growth factor signaling pathway 9
                regulation of vascular endothelial growth factor signaling pathway + 32
Path 2
Term Annotations click to browse term
  biological_process 17813
    biological regulation 12832
      regulation of biological process 12482
        regulation of cellular process 12025
          signal transduction 6956
            cell surface receptor signaling pathway 2787
              enzyme-linked receptor protein signaling pathway 1031
                cell surface receptor protein tyrosine kinase signaling pathway 652
                  vascular endothelial growth factor signaling pathway 54
                    VEGF-activated neuropilin signaling pathway + 2
                    VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                    negative regulation of vascular endothelial growth factor signaling pathway 18
                    positive regulation of cell migration by vascular endothelial growth factor signaling pathway + 7
                    positive regulation of vascular endothelial growth factor signaling pathway 9
                    regulation of vascular endothelial growth factor signaling pathway + 32
paths to the root