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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:vascular endothelial growth factor signaling pathway
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Accession:GO:0038084 term browser browse the term
Definition:The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Comment:In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
Synonyms:exact_synonym: VEGF signaling;   VEGF-activated signaling pathway;   vascular endothelial growth factor signalling pathway
 only_in_taxon: NCBITaxon:7742 ! Vertebrata


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vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT1 fms related receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr13:9,584,850...9,779,542 JBrowse link
G FLT4 fms related receptor tyrosine kinase 4 involved_in IEA GOC
Ensembl		 GO_REF:0000107 GO_REF:0000108 NCBI chr 5:175,804,728...175,852,703
Ensembl chr 5:183,115,856...183,149,006 		JBrowse link
G FOXC1 forkhead box C1 involved_in ISO (MGI:5314489|PMID:22171010) UniProt PMID:22171010 MGI:5314489 NCBI chr 6:1,429,051...1,433,180 JBrowse link
G GAB1 GRB2 associated binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:135,697,939...135,834,755
Ensembl chr 4:146,996,936...147,133,672 		JBrowse link
G KDR kinase insert domain receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G MYO1C myosin IC involved_in ISO (PMID:23262137) UniProt PMID:23262137 NCBI chr17:1,446,506...1,475,634
Ensembl chr17:1,345,143...1,375,540 		JBrowse link
G NRP1 neuropilin 1 involved_in IEA InterPro
GOC		 GO_REF:0000002 GO_REF:0000108 NCBI chr10:33,298,918...33,456,466
Ensembl chr10:33,883,173...34,039,648 		JBrowse link
G NRP2 neuropilin 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr2B:92,911,721...93,027,032
Ensembl chr2B:211,042,324...211,157,547 		JBrowse link
G NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit involved_in ISO (PMID:28602162) BHF-UCL PMID:28602162 NCBI chr 6:115,486,422...115,521,317 JBrowse link
G PGF placental growth factor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:55,494,152...55,508,066
Ensembl chr14:74,338,976...74,352,964 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:176,182,765...176,272,024
Ensembl chr 3:184,355,785...184,441,977 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta involved_in ISO (PMID:31915155) BHF-UCL PMID:31915155 NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G VEGFB vascular endothelial growth factor B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:59,591,750...59,595,926 JBrowse link
G VEGFC vascular endothelial growth factor C involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:168,870,941...168,999,160
Ensembl chr 4:181,104,737...181,236,030 		JBrowse link
G VEGFD vascular endothelial growth factor D involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:7,972,227...8,011,263
Ensembl chr  X:15,254,945...15,293,704 		JBrowse link
negative regulation of vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRA2 adhesion G protein-coupled receptor A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21421844) Ensembl
MGI		 PMID:21421844 GO_REF:0000107 NCBI chr 8:37,098,486...37,144,437
Ensembl chr 8:34,276,267...34,321,836 		JBrowse link
G CADM4 cell adhesion molecule 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:40,564,288...40,581,830
Ensembl chr19:49,172,485...49,180,023 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336 		JBrowse link
G DCN decorin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr12:88,678,791...88,715,677
Ensembl chr12:91,994,129...92,031,413 		JBrowse link
G EMILIN1 elastin microfibril interfacer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:27,077,551...27,085,437
Ensembl chr2A:27,166,747...27,174,525 		JBrowse link
G HRG histidine rich glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:183,701,069...183,712,365
Ensembl chr 3:192,168,299...192,180,539 		JBrowse link
G IL12A interleukin 12A acts_upstream_of
involved_in		 ISO
IEA		 (PMID:30106099) ARUK-UCL
Ensembl		 PMID:30106099 GO_REF:0000107 NCBI chr 3:157,011,675...157,019,897
Ensembl chr 3:165,061,505...165,068,666 		JBrowse link
G IL12B interleukin 12B acts_upstream_of
involved_in		 ISO
IEA		 (PMID:30106099) ARUK-UCL
Ensembl		 PMID:30106099 GO_REF:0000107 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:135,685,120...135,867,096
Ensembl chr 3:143,288,563...143,431,314 		JBrowse link
G SEMA6A semaphorin 6A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:111,793,272...111,924,937
Ensembl chr 5:117,592,313...117,651,098 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:61,569,658...61,574,817
Ensembl chr13:80,596,346...80,597,408 		JBrowse link
G XDH xanthine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:31,356,011...31,435,111
Ensembl chr2A:31,425,183...31,504,455 		JBrowse link
positive regulation of cell migration by vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYO1C myosin IC involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,446,506...1,475,634
Ensembl chr17:1,345,143...1,375,540 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,418,570...8,495,435
Ensembl chr 1:9,686,208...9,724,633 		JBrowse link
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDGFRA platelet derived growth factor receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPB1 heat shock protein family B (small) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984 		JBrowse link
G KDR kinase insert domain receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G PRKD1 protein kinase D1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:10,353,284...10,707,841
Ensembl chr14:28,496,282...28,650,030 		JBrowse link
G PRKD2 protein kinase D2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:43,666,591...43,710,858
Ensembl chr19:52,195,303...52,237,731 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
positive regulation of vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:51,648,293...51,941,329
Ensembl chr 4:57,966,197...58,259,404 		JBrowse link
G CCBE1 collagen and calcium binding EGF domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:52,819,591...53,087,772
Ensembl chr18:56,149,036...56,412,222 		JBrowse link
G ITGB1 integrin subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031 		JBrowse link
G JCAD junctional cadherin 5 associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:30,163,932...30,266,266
Ensembl chr10:30,528,772...30,553,865 		JBrowse link
G MYO1C myosin IC involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,446,506...1,475,634
Ensembl chr17:1,345,143...1,375,540 		JBrowse link
G ROBO1 roundabout guidance receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:78,707,802...79,876,519
Ensembl chr 3:80,581,388...81,569,308 		JBrowse link
G SMOC2 SPARC related modular calcium binding 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:166,430,178...166,664,577
Ensembl chr 6:171,366,929...171,589,084 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
regulation of vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD63 CD63 molecule involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:33,181,896...33,186,123
Ensembl chr12:33,906,314...33,910,595 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:168,440,192...168,449,071
Ensembl chr 6:173,534,292...173,544,759 		JBrowse link
G PTP4A3 protein tyrosine phosphatase 4A3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24403062) Ensembl
MGI		 PMID:24403062 GO_REF:0000107 NCBI chr 8:138,062,418...138,108,281
Ensembl chr 8:141,166,898...141,188,314 		JBrowse link
G TCF4 transcription factor 4 acts_upstream_of_or_within ISO (PMID:20231428) MGI PMID:20231428 NCBI chr18:48,603,069...48,969,010
Ensembl chr18:51,938,357...52,352,030 		JBrowse link
G TSPAN16 tetraspanin 16 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:10,844,955...10,864,526
Ensembl chr19:11,555,377...11,584,606 		JBrowse link
VEGF-activated neuropilin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NRP1 neuropilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:33,298,918...33,456,466
Ensembl chr10:33,883,173...34,039,648 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in ISO (PMID:24863063)
(MGI:5287519|PMID:21828096)
(MGI:5141569|PMID:21658587)		 BHF-UCL PMID:21658587 PMID:21828096 PMID:24863063 MGI:5141569 MGI:5287519 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    response to stimulus 8500
      response to endogenous stimulus 2053
        cellular response to endogenous stimulus 1627
          cellular response to growth factor stimulus 797
            cellular response to vascular endothelial growth factor stimulus 64
              vascular endothelial growth factor signaling pathway 45
                VEGF-activated neuropilin signaling pathway + 2
                VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                negative regulation of vascular endothelial growth factor signaling pathway 12
                positive regulation of cell migration by vascular endothelial growth factor signaling pathway + 7
                positive regulation of vascular endothelial growth factor signaling pathway 8
                regulation of vascular endothelial growth factor signaling pathway + 25
Path 2
Term Annotations click to browse term
  biological_process 16440
    biological regulation 11453
      regulation of biological process 11104
        regulation of cellular process 10598
          signal transduction 5440
            cell surface receptor signaling pathway 2631
              enzyme-linked receptor protein signaling pathway 947
                cell surface receptor protein tyrosine kinase signaling pathway 618
                  vascular endothelial growth factor signaling pathway 45
                    VEGF-activated neuropilin signaling pathway + 2
                    VEGF-activated platelet-derived growth factor receptor signaling pathway + 3
                    negative regulation of vascular endothelial growth factor signaling pathway 12
                    positive regulation of cell migration by vascular endothelial growth factor signaling pathway + 7
                    positive regulation of vascular endothelial growth factor signaling pathway 8
                    regulation of vascular endothelial growth factor signaling pathway + 25
paths to the root