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ONTOLOGY REPORT - ANNOTATIONS


Term:p38MAPK cascade
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Accession:GO:0038066 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: p38 MAPK cascade;   p38 cascade



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p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO MGI:2443472|MGI:3720850|MGI:3842320 (MGI:3719954|PMID:17699753), (MGI:4420477|PMID:19948881), (MGI:5007596|PMID:21533046) RGD PMID:17699753 PMID:19948881 PMID:21533046 MGI:3719954 MGI:4420477 MGI:5007596 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf7 activating transcription factor 7 involved_in ISO MGI:109349 (MGI:3719954|PMID:17699753) RGD PMID:17699753 MGI:3719954 NCBI chr 7:133,660,491...133,750,902
Ensembl chr 7:133,663,294...133,750,848
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO MGI:2135670 (MGI:4437389|PMID:20053668) RGD PMID:20053668 MGI:4437389 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 involved_in ISO (PMID:22696064) RGD PMID:22696064 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:11836244) RGD PMID:11836244 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 acts_upstream_of_or_within ISO (PMID:22337877) RGD PMID:22337877 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000002
(MGI:5526919|PMID:22847234)
GO_REF:0000107
UniProt
InterPro
RGD
Ensembl
PMID:22847234 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:5526919 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 acts_upstream_of_or_within ISO (MGI:5532755|PMID:24020373) RGD PMID:24020373 MGI:5532755 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 acts_upstream_of_or_within ISO (PMID:22337877) RGD PMID:22337877 NCBI chr 4:124,610,216...124,666,813
Ensembl chr 4:124,608,960...124,661,902
JBrowse link
G Pbk PDZ binding kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
JBrowse link
G Zfp36 zinc finger protein 36 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5784995|PMID:11533235)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:11533235 GO_REF:0000024 GO_REF:0000107 MGI:5784995 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5784987|PMID:17889962)
UniProt
RGD
PMID:17889962 GO_REF:0000024 MGI:5784987 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
JBrowse link
negative regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in ISS
ISO
GO_REF:0000024
(PMID:29291351)
(MGI:6162308|PMID:29291351)
UniProt
RGD
PMID:29291351 GO_REF:0000024 MGI:6162308 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in ISO
IEA
(PMID:20551903)
GO_REF:0000107
RGD
Ensembl
PMID:20551903 GO_REF:0000107 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISO
IBA
(PMID:22991462)
PMID:21873635
RGD PMID:22991462 PMID:21873635 RGD:13792537 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO (PMID:10391943) RGD PMID:10391943 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Ezr ezrin involved_in ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 acts_upstream_of_or_within ISO MGI:1346865 (MGI:3822965|PMID:18681888) RGD PMID:18681888 MGI:3822965 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Mir20a microRNA 20a involved_in ISO (PMID:22696064) RGD PMID:22696064 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO
IBA
(PMID:23991106)
PMID:21873635
(MGI:5640942|PMID:23991106)
RGD PMID:23991106 PMID:21873635 MGI:5640942, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695687|PMID:31900229) RGD PMID:31900229 MGI:6695687 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
positive regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO ComplexPortal:CPX-1134|UniProtKB:P10749 (PMID:20739563) RGD PMID:20739563 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:22540193)
Ensembl
RGD
PMID:22540193 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO
IEA
(PMID:17600318)
GO_REF:0000107
RGD
Ensembl
PMID:17600318 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IDA RGD PMID:18584881 RGD:2303073 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISS
ISO
GO_REF:0000024
(MGI:6163930|PMID:28931551)
UniProt
RGD
PMID:28931551 GO_REF:0000024 MGI:6163930 NCBI chr 1:94,980,260...94,988,847
Ensembl chr 1:94,943,587...94,988,847
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha involved_in ISO
IEA
(PMID:9827804)
GO_REF:0000107
RGD
Ensembl
PMID:9827804 GO_REF:0000107 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gdf6 growth differentiation factor 6 involved_in ISS
ISO
GO_REF:0000024
(MGI:5751611|PMID:26774823)
UniProt
RGD
PMID:26774823 GO_REF:0000024 MGI:5751611 NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:24161931)
Ensembl
RGD
PMID:24161931 GO_REF:0000107 NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891
JBrowse link
G Il1b interleukin 1 beta involved_in ISO ComplexPortal:CPX-1134|UniProtKB:Q15109 (MGI:5902681|PMID:20739563) RGD PMID:20739563 MGI:5902681 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lep leptin involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:24340098)
UniProt
RGD
PMID:24340098 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 acts_upstream_of_or_within ISO (MGI:1353859|PMID:10700190) RGD PMID:10700190 MGI:1353859 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 involved_in ISO (PMID:9305639) RGD PMID:9305639 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IMP RGD PMID:20716917 RGD:10412640 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:3041135 (MGI:5529574|PMID:23994610) RGD PMID:23994610 MGI:5529574 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28471450) RGD PMID:28471450 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
JBrowse link
G Mink1 misshapen-like kinase 1 involved_in ISO (MGI:1354211|PMID:10708748) RGD PMID:10708748 MGI:1354211 NCBI chr10:55,278,293...55,330,782
Ensembl chr10:55,278,391...55,330,782
JBrowse link
G Mir181a2 microRNA 181a-2 involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
JBrowse link
G Mir181b1 microRNA 181b-1 involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797
JBrowse link
G Mir181b2 microRNA 181b-2 involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035
JBrowse link
G Mir181d microRNA 181d involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Oprk1 opioid receptor, kappa 1 IDA RGD PMID:16648139 RGD:9831415 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:28471450)
UniProt
RGD
PMID:28471450 GO_REF:0000024 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in IDA PMID:23483889 BHF-UCL PMID:23483889 RGD:10047341 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Rell1 RELT-like 1 involved_in IBA
ISO
PMID:21873635
(PMID:28688764)
RGD PMID:28688764 PMID:21873635 RGD:13792537 NCBI chr14:44,318,640...44,378,541
Ensembl chr14:44,303,009...44,378,500
JBrowse link
G Rell2 RELT-like 2 involved_in IBA
ISO
ISS
PMID:21873635
(PMID:28688764)
GO_REF:0000024
RGD
UniProt
PMID:28688764 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr18:29,789,996...29,793,986
Ensembl chr18:29,790,415...29,793,986
JBrowse link
G Sash1 SAM and SH3 domain containing 1 acts_upstream_of_or_within ISO (PMID:23776175) RGD PMID:23776175 NCBI chr 1:3,119,915...3,418,536
Ensembl chr 1:3,121,332...3,439,870
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:23935096)
UniProt
Ensembl
RGD
PMID:23935096 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:6478061|PMID:28912174) RGD PMID:28912174 MGI:6478061 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
G Stk39 serine threonine kinase 39 involved_in ISO
IMP
(PMID:10980603) RGD PMID:10980603 PMID:10980603 RGD:727300 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:18386220) RGD PMID:18386220 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase involved_in ISO
IEA
(PMID:18386220)
GO_REF:0000107
RGD
Ensembl
PMID:18386220 GO_REF:0000107 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISO (PMID:24048733) RGD PMID:24048733 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IBA
ComplexPortal:CPX-1134 (MGI:6094326|PMID:18367618)
PMID:21873635
RGD PMID:18367618 PMID:21873635 MGI:6094326, RGD:13792537 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Cav3 caveolin 3 acts_upstream_of_or_within ISO (MGI:4946902|PMID:21182936) RGD PMID:21182936 MGI:4946902 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
GO_REF:0000024
(MGI:4453088|PMID:19948740)
UniProt
RGD
PMID:19948740 GO_REF:0000024 MGI:4453088 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Hgf hepatocyte growth factor acts_upstream_of_or_within ISO (MGI:5529574|PMID:23994610) RGD PMID:23994610 MGI:5529574 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:24465902) RGD PMID:24465902 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Per1 period circadian regulator 1 involved_in IMP PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 involved_in ISO
IEA
(PMID:17386267)
GO_REF:0000107
RGD
Ensembl
PMID:17386267 GO_REF:0000107 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 NOT|involved_in ISO (PMID:19933860) RGD PMID:19933860 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 NOT|involved_in ISO (MGI:5440106|PMID:23021218) RGD PMID:23021218 MGI:5440106 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Ulk4 unc-51 like kinase 4 acts_upstream_of_or_within ISO (PMID:24284070) RGD PMID:24284070 NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    cellular process 17586
      signal transduction 6838
        intracellular signal transduction 2675
          MAPK cascade 852
            stress-activated MAPK cascade 256
              p38MAPK cascade 65
                negative regulation of p38MAPK cascade 9
                positive regulation of p38MAPK cascade 36
                regulation of p38MAPK cascade + 54
Path 2
Term Annotations click to browse term
  biological_process 18877
    biological regulation 13380
      regulation of biological process 12644
        regulation of cellular process 11961
          signal transduction 6838
            intracellular signal transduction 2675
              MAPK cascade 852
                stress-activated MAPK cascade 256
                  p38MAPK cascade 65
                    negative regulation of p38MAPK cascade 9
                    positive regulation of p38MAPK cascade 36
                    regulation of p38MAPK cascade + 54
paths to the root