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ONTOLOGY REPORT - ANNOTATIONS

Term:NIK/NF-kappaB signaling
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Accession:GO:0038061 term browser browse the term
Definition:The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
Synonyms:exact_synonym: NIK/NF-kappaB signal transduction
 narrow_synonym: p52-dependent NF-kappaB signaling
 broad_synonym: non-canonical NF-KB signaling;   noncanonical NF-kappaB signaling;   noncanonical nuclear factor kappaB (NF-kappaB) pathway
 related_synonym: NIK-IKK cascade;   NIK-IKK kinase cascade;   NIK-IKK signaling pathway;   NIK-IKK-alpha cascade;   NIK/NF-kappaB cascade


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NIK/NF-kappaB signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Dicer1 dicer 1 ribonuclease III involved_in ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Il18 interleukin 18 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:2136797|PMID:10227969)
GO_REF:0000107		 RGD
Ensembl		 PMID:10227969 GO_REF:0000107 MGI:2136797 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of
involved_in		 ISO
IEA		 MGI:2136765 (MGI:2136797|PMID:10227969)
GO_REF:0000107		 RGD
Ensembl		 PMID:10227969 GO_REF:0000107 MGI:2136797 NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:26435691) RGD PMID:26435691 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir130a microRNA 130a involved_in ISO (PMID:26435691) RGD PMID:26435691 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629 		JBrowse link
G Mir146a microRNA 146a involved_in ISO (PMID:20937840) RGD PMID:20937840 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 acts_upstream_of_or_within ISO (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 acts_upstream_of
involved_in		 ISO
IEA		 MGI:4836357 (MGI:5436198|PMID:22503542)
GO_REF:0000107		 RGD
Ensembl		 PMID:22503542 GO_REF:0000107 MGI:5436198 NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of
involved_in		 ISO
IEA		 MGI:3529594 (MGI:5299952|PMID:22033934)
GO_REF:0000107		 RGD
Ensembl		 PMID:22033934 GO_REF:0000107 MGI:5299952 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:5486592|PMID:23583643)		 RGD PMID:23583643 PMID:21873635 MGI:5486592, RGD:13792537 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000108
(MGI:1345788|PMID:10490590)		 GOC
RGD		 PMID:10490590 GO_REF:0000108 MGI:1345788 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of ISO MGI:2674036 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats acts_upstream_of ISO MGI:3043446 (MGI:3041925|PMID:14961764) RGD PMID:14961764 MGI:3041925 NCBI chr 8:61,259,415...61,347,789
Ensembl chr 8:61,259,477...61,347,789 		JBrowse link
activation of NF-kappaB-inducing kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within ISO (MGI:3844151|PMID:19404405) RGD PMID:19404405 MGI:3844151 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Card10 caspase recruitment domain family, member 10 involved_in ISO (PMID:11259443) RGD PMID:11259443 NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224 		JBrowse link
G Chi3l1 chitinase 3 like 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5306542|PMID:21546314)		 UniProt
RGD		 PMID:21546314 GO_REF:0000024 MGI:5306542 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Cops8 COP9 signalosome subunit 8 involved_in ISO (PMID:22992343) RGD PMID:22992343 NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma acts_upstream_of_or_within ISO (MGI:2682548|PMID:14654787) RGD PMID:14654787 MGI:2682548 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in ISO (PMID:11397809) RGD PMID:11397809 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 NOT|acts_upstream_of_or_within ISO (MGI:2388552|PMID:12220507) RGD PMID:12220507 MGI:2388552 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Malt1 MALT1 paracaspase involved_in ISO (PMID:15125833) RGD PMID:15125833 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (PMID:10094049), (PMID:15125833) RGD PMID:10094049 PMID:15125833 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor acts_upstream_of_or_within ISO MGI:2158808 (MGI:3844151|PMID:19404405) RGD PMID:19404405 MGI:3844151 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:24275656) RGD PMID:24275656 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432 		JBrowse link
G Tnfsf15 TNF superfamily member 15 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11911831)
GO_REF:0000107		 RGD
Ensembl		 PMID:11911831 GO_REF:0000107 NCBI chr 5:77,140,099...77,156,142
Ensembl chr 5:77,139,878...77,156,228 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 involved_in ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf4 Tnf receptor associated factor 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:15125833) RGD PMID:15125833 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Zfp91 zinc finger protein 91 involved_in ISO (PMID:20682767) RGD PMID:20682767 NCBI chr 1:209,891,344...209,928,890
Ensembl chr 1:209,891,344...209,927,762 		JBrowse link
negative regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrg3 adhesion G protein-coupled receptor G3 involved_in ISO (MGI:5645196|PMID:24113187) RGD PMID:24113187 MGI:5645196 NCBI chr19:9,972,425...10,001,118
Ensembl chr19:9,972,430...10,001,123 		JBrowse link
G Adipor1 adiponectin receptor 1 involved_in ISO (PMID:23776679) RGD PMID:23776679 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G C1qtnf3 C1q and TNF related 3 involved_in ISO (PMID:16213490) RGD PMID:16213490 NCBI chr 2:59,917,099...59,939,519
Ensembl chr 2:59,917,188...59,939,433 		JBrowse link
G Capn1 calpain 1 IMP RGD PMID:21415394 RGD:13792556 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISO
ISS		 (PMID:21063504)
GO_REF:0000024		 RGD
UniProt		 PMID:21063504 GO_REF:0000024 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Cpne1 copine 1 involved_in ISO (PMID:18212740) RGD PMID:18212740 NCBI chr 3:144,587,548...144,629,603
Ensembl chr 3:144,588,995...144,598,636 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO
ISS		 (PMID:18313383)
GO_REF:0000024		 RGD
UniProt		 PMID:18313383 GO_REF:0000024 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:27736973) RGD PMID:27736973 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 involved_in ISO (MGI:2176150|PMID:11896578) RGD PMID:11896578 MGI:2176150 NCBI chr10:17,232,735...17,330,584
Ensembl chr10:17,227,181...17,330,571 		JBrowse link
G Hdac7 histone deacetylase 7 involved_in ISO (PMID:25411248) RGD PMID:25411248 NCBI chr 7:128,923,918...128,962,025
Ensembl chr 7:128,923,920...128,962,072 		JBrowse link
G Ifi35 interferon-induced protein 35 involved_in ISO (PMID:29350881) RGD PMID:29350881 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor acts_upstream_of_or_within ISO (MGI:2672995|PMID:12914755) RGD PMID:12914755 MGI:2672995 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763 		JBrowse link
G Mir146a microRNA 146a involved_in ISO (PMID:25515214) RGD PMID:25515214 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO UniProtKB:P05067 (PMID:29961672) RGD PMID:29961672 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir204 microRNA 204 acts_upstream_of ISO (PMID:29441883) RGD PMID:29441883 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:19946272) RGD PMID:19946272 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir27b microRNA 27b acts_upstream_of_or_within ISO UniProtKB:P01375 (PMID:31124343) RGD PMID:31124343 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529 		JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:26687115) RGD PMID:26687115 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:26687115) RGD PMID:26687115 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir30c2 microRNA 30c-2 involved_in ISO (PMID:25732226) RGD PMID:25732226 NCBI chr 9:25,757,342...25,757,425
Ensembl chr 9:25,757,342...25,757,425 		JBrowse link
G Mir9-3 microRNA 9-3 acts_upstream_of ISO (PMID:26354749) RGD PMID:26354749 NCBI chr 1:133,440,049...133,440,138 JBrowse link
G Mkrn2 makorin, ring finger protein, 2 involved_in ISO (MGI:6827195|PMID:18198183) RGD PMID:18198183 MGI:6827195 NCBI chr 4:148,661,529...148,679,580
Ensembl chr 4:148,661,553...148,679,642 		JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:25277106) RGD PMID:25277106 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 involved_in
acts_upstream_of_or_within		 ISO (PMID:17237370)
MGI:4836357 (MGI:5436198|PMID:22503542)		 RGD PMID:17237370 PMID:22503542 MGI:5436198 NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO
IBA		 (PMID:14662828)
PMID:21873635		 RGD PMID:14662828 PMID:21873635 RGD:13792537 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nmi N-myc (and STAT) interactor involved_in ISO (PMID:29350881) RGD PMID:29350881 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A involved_in ISO
IEA
ISS		 (PMID:18930133)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18930133 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B involved_in ISS
ISO		 GO_REF:0000024
(PMID:18930133)		 UniProt
RGD		 PMID:18930133 GO_REF:0000024 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974 		JBrowse link
G Rassf2 Ras association domain family member 2 acts_upstream_of_or_within ISO (MGI:5314467|PMID:22227519) RGD PMID:22227519 MGI:5314467 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO (PMID:18212740) RGD PMID:18212740 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (PMID:28362429) RGD PMID:28362429 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked involved_in ISO (PMID:21343177) RGD PMID:21343177 NCBI chr  X:27,144,677...27,146,667
Ensembl chr  X:27,128,610...27,146,667 		JBrowse link
G Tspan6 tetraspanin 6 involved_in ISO (PMID:22908223) RGD PMID:22908223 NCBI chr  X:97,092,394...97,099,659
Ensembl chr  X:97,092,388...97,099,309 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:3043446 (MGI:3041925|PMID:14961764)		 RGD PMID:14961764 PMID:21873635 MGI:3041925, RGD:13792537 NCBI chr 8:61,259,415...61,347,789
Ensembl chr 8:61,259,477...61,347,789 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISS
ISO		 GO_REF:0000024
(MGI:5142149|PMID:21616078)		 UniProt
RGD		 PMID:21616078 GO_REF:0000024 MGI:5142149 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
positive regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn4 actinin alpha 4 involved_in ISO (PMID:25411248) RGD PMID:25411248 NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847 		JBrowse link
G Ager advanced glycosylation end product-specific receptor involved_in ISO UniProtKB:P05067 (PMID:15457210) RGD PMID:15457210 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ago1 argonaute RISC component 1 involved_in ISO (MGI:5788605|PMID:26764146) RGD PMID:26764146 MGI:5788605 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 involved_in ISO (MGI:5788605|PMID:26764146) RGD PMID:26764146 MGI:5788605 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:22406537)
UniProtKB:Q15109 (PMID:15457210), (PMID:29961672)		 RGD PMID:15457210 PMID:22406537 PMID:29961672 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G C1qtnf4 C1q and TNF related 4 involved_in ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139 		JBrowse link
G Calr calreticulin acts_upstream_of_or_within ISO (MGI:5617678|PMID:24998604) RGD PMID:24998604 MGI:5617678 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15059845) RGD PMID:15059845 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Cd14 CD14 molecule involved_in ISO
IBA		 (PMID:15294986)
PMID:21873635		 RGD PMID:15294986 PMID:21873635 RGD:13792537 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:23736979) RGD PMID:23736979 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cd86 CD86 molecule involved_in ISO (MGI:5461234|PMID:23241883) RGD PMID:23241883 MGI:5461234 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Crebbp CREB binding protein IMP RGD PMID:20926146 RGD:10059423 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:30341167) RGD PMID:30341167 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Eda ectodysplasin-A acts_upstream_of_or_within ISO (MGI:3617077|PMID:12629675) RGD PMID:12629675 MGI:3617077 NCBI chr  X:65,078,454...65,480,172
Ensembl chr  X:65,078,673...65,480,172 		JBrowse link
G Edar ectodysplasin-A receptor acts_upstream_of_or_within ISO (MGI:3617077|PMID:12629675) RGD PMID:12629675 MGI:3617077 NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494 		JBrowse link
G Edaradd EDAR-associated death domain IMP RGD PMID:22013926 RGD:14398762 NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447 		JBrowse link
G Edn1 endothelin 1 involved_in IDA PMID:28484848 BHF-UCL PMID:28484848 RGD:13601996 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5487533|PMID:20038207)		 UniProt
RGD		 PMID:20038207 GO_REF:0000024 MGI:5487533 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:23811396) RGD PMID:23811396 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Glrx glutaredoxin IMP RGD PMID:19938943 RGD:9686063 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist acts_upstream_of_or_within ISO (MGI:3805145|PMID:18505784) RGD PMID:18505784 MGI:3805145 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:3763563|PMID:18006747) RGD PMID:18006747 MGI:3763563 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645)
(MGI:5788395|PMID:16267105)		 RGD PMID:14660645 PMID:16267105 MGI:5788395 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Ifi35 interferon-induced protein 35 involved_in ISO (MGI:6099204|PMID:29038465) RGD PMID:29038465 MGI:6099204 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952 		JBrowse link
G Il18 interleukin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:2136797|PMID:10227969)		 Ensembl
RGD		 PMID:10227969 GO_REF:0000107 MGI:2136797 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18r1 interleukin 18 receptor 1 acts_upstream_of_or_within ISO MGI:2136765 (MGI:2136797|PMID:10227969) RGD PMID:10227969 MGI:2136797 NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:18390750) RGD PMID:18390750 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ilk integrin-linked kinase involved_in ISO (PMID:21343177) RGD PMID:21343177 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in ISO (PMID:25515214) RGD PMID:25515214 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:6391873|PMID:22733818) RGD PMID:22733818 MGI:6391873 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:25754930) RGD PMID:25754930 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Lims1 LIM zinc finger domain containing 1 involved_in ISO (PMID:21343177) RGD PMID:21343177 NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500 		JBrowse link
G Lrrc19 leucine rich repeat containing 19 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:4365690|PMID:19679103)
(PMID:19679103)		 RGD PMID:19679103 PMID:21873635 MGI:4365690, RGD:13792537 NCBI chr 5:109,497,503...109,502,488
Ensembl chr 5:109,497,121...109,507,938 		JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6201889|PMID:25049354)		 Ensembl
RGD		 PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 involved_in ISO (PMID:25515214) RGD PMID:25515214 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 involved_in ISO (PMID:12019269) RGD PMID:12019269 NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934 		JBrowse link
G Nmi N-myc (and STAT) interactor involved_in ISO (PMID:29038465) RGD PMID:29038465 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 involved_in ISO (PMID:25093298) RGD PMID:25093298 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:25093298)
MGI:3529594 (MGI:5299952|PMID:22033934)		 RGD PMID:22033934 PMID:25093298 MGI:5299952 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 involved_in ISO (PMID:30769772) RGD PMID:30769772 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISO (PMID:19946272) RGD PMID:19946272 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Phb1 prohibitin 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5461234|PMID:23241883)		 UniProt
RGD		 PMID:23241883 GO_REF:0000024 MGI:5461234 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Phb2 prohibitin 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5461234|PMID:23241883)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23241883 GO_REF:0000024 GO_REF:0000107 MGI:5461234 NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Ptp4a3 protein tyrosine phosphatase 4A3 involved_in ISO (PMID:23178297) RGD PMID:23178297 NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:4437982|PMID:19136968)		 Ensembl
RGD		 PMID:19136968 GO_REF:0000107 MGI:4437982 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO (PMID:21343177), (PMID:23178297) RGD PMID:21343177 PMID:23178297 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G RGD1311739 similar to RIKEN cDNA 1700037H04 involved_in ISO (PMID:32024300) RGD PMID:32024300 NCBI chr 3:118,364,730...118,378,881
Ensembl chr 3:118,362,363...118,378,838 		JBrowse link
G Rhoa ras homolog family member A involved_in ISO (PMID:25515214) RGD PMID:25515214 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:20041225) RGD PMID:20041225 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Rtkn2 rhotekin 2 involved_in ISO (PMID:26124677) RGD PMID:26124677 NCBI chr20:20,525,256...20,609,951
Ensembl chr20:20,525,256...20,609,951 		JBrowse link
G Sash1 SAM and SH3 domain containing 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(PMID:23776175)		 RGD PMID:23776175 PMID:21873635 RGD:13792537 NCBI chr 1:3,119,915...3,418,536
Ensembl chr 1:3,121,332...3,439,870 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:14720208 RGD:10042970 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:20577214)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:20577214 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Tcim transcriptional and immune response regulator involved_in ISO (PMID:19684084) RGD PMID:19684084 NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581 		JBrowse link
G Tlr2 toll-like receptor 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:19740627)
MGI:2674036 (MGI:5299952|PMID:22033934)		 RGD PMID:19740627 PMID:22033934 MGI:5299952 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:19740627) RGD PMID:19740627 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in ISO
IEA		 (PMID:19740627)
GO_REF:0000107		 RGD
Ensembl		 PMID:19740627 GO_REF:0000107 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr7 toll-like receptor 7 involved_in ISO (PMID:19740627) RGD PMID:19740627 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (PMID:19740627) RGD PMID:19740627 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor involved_in
acts_upstream_of_or_within		 ISO (PMID:17922812), (PMID:20041225)
(PMID:31124343)
(MGI:5285024|PMID:21689636)		 RGD PMID:17922812 PMID:20041225 PMID:21689636 PMID:31124343 MGI:5285024 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf14 TNF superfamily member 14 involved_in ISO (PMID:12393901) RGD PMID:12393901 NCBI chr 9:2,069,075...2,073,128
Ensembl chr 9:2,069,104...2,073,216 		JBrowse link
G Tradd TNFRSF1A-associated via death domain involved_in ISO (PMID:25732226) RGD PMID:25732226 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:25515214) RGD PMID:25515214 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6294162|PMID:28592261) RGD PMID:28592261 MGI:6294162 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trim44 tripartite motif-containing 44 involved_in ISO
IEA		 (PMID:23460740)
GO_REF:0000107		 RGD
Ensembl		 PMID:23460740 GO_REF:0000107 NCBI chr 3:88,597,962...88,729,085
Ensembl chr 3:88,592,719...88,729,188 		JBrowse link
G Trip6 thyroid hormone receptor interactor 6 involved_in IBA
ISO		 PMID:21873635
(PMID:15657077)		 RGD PMID:15657077 PMID:21873635 RGD:13792537 NCBI chr12:19,386,212...19,390,619
Ensembl chr12:19,386,014...19,390,618 		JBrowse link
regulation of NIK/NF-kappaB signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akip1 A-kinase interacting protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:163,734,730...163,743,648
Ensembl chr 1:163,734,798...163,743,648 		JBrowse link
G Bcl3 BCL3, transcription coactivator involved_in ISO (PMID:8196632) RGD PMID:8196632 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 acts_upstream_of_or_within ISO MGI:1197007 (MGI:3819901|PMID:18621737) RGD PMID:18621737 MGI:3819901 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 acts_upstream_of_or_within ISO MGI:1197009 (MGI:3819901|PMID:18621737) RGD PMID:18621737 MGI:3819901 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 NOT|involved_in ISO (PMID:20551903) RGD PMID:20551903 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Eda ectodysplasin-A involved_in ISO (PMID:27144394) RGD PMID:27144394 NCBI chr  X:65,078,454...65,480,172
Ensembl chr  X:65,078,673...65,480,172 		JBrowse link
G Ezr ezrin NOT|involved_in ISO (PMID:20551903) RGD PMID:20551903 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Lime1 Lck interacting transmembrane adaptor 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3769059|PMID:16249387)		 RGD PMID:16249387 PMID:21873635 MGI:3769059, RGD:13792537 NCBI chr 3:168,490,535...168,496,627
Ensembl chr 3:168,490,074...168,493,127 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5617337|PMID:24440909)		 Ensembl
RGD		 PMID:24440909 GO_REF:0000107 MGI:5617337 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Prdx1 peroxiredoxin 1 acts_upstream_of_or_within ISO (MGI:3578073|PMID:15858817) RGD PMID:15858817 MGI:3578073 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO
IBA		 (PMID:23991106)
(MGI:5640942|PMID:23991106)
PMID:21873635		 RGD PMID:23991106 PMID:21873635 MGI:5640942, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Rassf2 Ras association domain family member 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:5314787 (MGI:5314467|PMID:22227519)		 RGD PMID:22227519 PMID:21873635 MGI:5314467, RGD:13792537 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO UniProtKB:P62328 (PMID:21343177) RGD PMID:21343177 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tek TEK receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:108448 (MGI:4437182|PMID:20060382) RGD PMID:20060382 MGI:4437182 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked involved_in ISO UniProtKB:Q04206 (PMID:21343177) RGD PMID:21343177 NCBI chr  X:27,144,677...27,146,667
Ensembl chr  X:27,128,610...27,146,667 		JBrowse link
G Trim6 tripartite motif containing 6 NOT|involved_in ISO (PMID:24882218) RGD PMID:24882218 NCBI chr 1:158,683,746...158,696,936
Ensembl chr 1:158,683,746...158,696,914 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    signaling 7399
      signal transduction 6838
        intracellular signal transduction 2675
          NIK/NF-kappaB signaling 138
            activation of NF-kappaB-inducing kinase activity 16
            negative regulation of NIK/NF-kappaB signaling 36
            positive regulation of NIK/NF-kappaB signaling 69
            regulation of NIK/NF-kappaB signaling + 112
Path 2
Term Annotations click to browse term
  biological_process 18877
    biological regulation 13380
      regulation of biological process 12644
        regulation of cellular process 11961
          signal transduction 6838
            intracellular signal transduction 2675
              NIK/NF-kappaB signaling 138
                activation of NF-kappaB-inducing kinase activity 16
                negative regulation of NIK/NF-kappaB signaling 36
                positive regulation of NIK/NF-kappaB signaling 69
                regulation of NIK/NF-kappaB signaling + 112
paths to the root