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ONTOLOGY REPORT - ANNOTATIONS
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Term:
G protein-coupled estrogen receptor activity
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Accession:
GO:0038054
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Definition:
Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Synonyms:
broad_synonym:
estrogen receptor activity
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Genes (2)
G protein-coupled estrogen receptor activity
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Esr1
estrogen receptor 1
enables
ISO
(PMID:16645038)
UniProt
PMID:16645038
NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171
G
Gper1
G protein-coupled estrogen receptor 1
enables
ISO
PMID:23283935
UniProt
PMID:23283935
RGD:8553898
NCBI chrNW_004936754:1,288,891...1,293,555
Ensembl chrNW_004936754:1,288,912...1,293,427
Term paths to the root
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Path 1
Term
Annotations
molecular_function
17081
molecular transducer activity
1651
signaling receptor activity
1651
transmembrane signaling receptor activity
1472
G protein-coupled receptor activity
1127
G protein-coupled estrogen receptor activity
2
Path 2
Term
Annotations
molecular_function
17081
transcription regulator activity
1484
DNA-binding transcription factor activity
1045
DNA-binding transcription factor activity, RNA polymerase II-specific
1005
nuclear steroid receptor activity
19
nuclear estrogen receptor activity
4
G protein-coupled estrogen receptor activity
2