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ONTOLOGY REPORT - ANNOTATIONS


Term:large latent transforming growth factor-beta complex
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Accession:GO:0038045 term browser browse the term
Definition:A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.
Synonyms:exact_synonym: LLC;   large latent complex


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large latent transforming growth factor-beta complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp1 latent transforming growth factor beta binding protein 1 IDA RGD PMID:11907708 RGD:10412304 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451
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  cellular_component 20609
    protein-containing complex 6093
      large latent transforming growth factor-beta complex 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.