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ONTOLOGY REPORT - ANNOTATIONS

Term:ERAD pathway
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Accession:GO:0036503 term browser browse the term
Definition:The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
Synonyms:exact_synonym: endoplasmic reticulum-associated degradation;   protein degradation by ERAD
 related_synonym: ER-associated degradation pathway;   endoplasmic reticulum-associated protein degradation pathway


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ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO (PMID:11724934), (PMID:16168377), (PMID:17872946), (PMID:24810856) RGD PMID:11724934 PMID:16168377 PMID:17872946 PMID:24810856 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:76,688,194...76,695,162
Ensembl chr 9:76,688,194...76,696,469 		JBrowse link
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000002
(PMID:21857022), (PMID:23223569)
GO_REF:0000024		 GO_Central
InterPro
RGD
UniProt		 PMID:21857022 PMID:23223569 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in IBA
ISO
ISS
IEA		 GO_REF:0000033
(PMID:23129660), (PMID:24981174), (PMID:26565908)
GO_REF:0000024
GO_REF:0000107		 GO_Central
RGD
UniProt
Ensembl		 PMID:23129660 PMID:24981174 PMID:26565908 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISO
IEA		 (PMID:23907667)
GO_REF:0000107		 RGD
Ensembl		 PMID:23907667 GO_REF:0000107 NCBI chr 1:197,035,505...197,088,624
Ensembl chr 1:197,035,633...197,088,092 		JBrowse link
G Calr calreticulin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Calr3 calreticulin 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015 		JBrowse link
G Calr4 calreticulin 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:123,986,870...124,022,436
Ensembl chr 5:123,987,474...124,022,417 		JBrowse link
G Canx calnexin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:25009997)
MGI:3722141 (PMID:25009997)
GO_REF:0000024		 RGD
UniProt		 PMID:25009997 GO_REF:0000024 NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881 		JBrowse link
G Clgn calmegin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758 		JBrowse link
G Derl1 derlin 1 involved_in ISO
IBA		 (PMID:15215856), (PMID:17872946), (PMID:18555783), (PMID:24089527), (PMID:25239945)
GO_REF:0000033		 RGD
GO_Central		 PMID:15215856 PMID:17872946 PMID:18555783 PMID:24089527 PMID:25239945 GO_REF:0000033 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Derl2 derlin 2 involved_in ISO
IBA		 (PMID:16449189)
GO_REF:0000033		 RGD
GO_Central		 PMID:16449189 GO_REF:0000033 NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Derl3 derlin 3 involved_in ISO
IBA		 (PMID:22607976)
GO_REF:0000033		 RGD
GO_Central		 PMID:22607976 GO_REF:0000033 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027 		JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 involved_in ISO (PMID:21148293), (PMID:21150129) RGD PMID:21148293 PMID:21150129 NCBI chr20:27,828,216...27,846,428
Ensembl chr20:27,828,235...27,846,427 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 involved_in ISO
IBA		 (PMID:15936278)
GO_REF:0000033		 RGD
GO_Central		 PMID:15936278 GO_REF:0000033 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:22267725)
GO_REF:0000033
(MGI:5499714|PMID:22267725)
(PMID:18400946)		 UniProt
RGD
GO_Central		 PMID:18400946 PMID:22267725 GO_REF:0000024 GO_REF:0000033 MGI:5499714 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4943381|PMID:18653895), (MGI:4947480|PMID:21329881)
(PMID:18400946)		 UniProt
RGD		 PMID:18400946 PMID:18653895 PMID:21329881 GO_REF:0000024 MGI:4943381 MGI:4947480 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Ecpas Ecm29 proteasome adaptor and scaffold involved_in IBA
ISO		 GO_REF:0000033
(PMID:15496406)		 GO_Central
RGD		 PMID:15496406 GO_REF:0000033 NCBI chr 5:73,601,745...73,714,026
Ensembl chr 5:73,604,533...73,713,860 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:21062743), (PMID:25092655)
(PMID:11375934)		 RGD PMID:11375934 PMID:21062743 PMID:25092655 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in ISO (PMID:15537790), (PMID:25092655) RGD PMID:15537790 PMID:25092655 NCBI chr 3:144,201,604...144,227,423
Ensembl chr 3:144,201,605...144,227,485 		JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 involved_in ISO (PMID:25092655)
(PMID:16431915)
(MGI:3654428|PMID:16431915)		 RGD PMID:16431915 PMID:25092655 MGI:3654428 NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:6467680|PMID:17707796)
(PMID:17707796)		 RGD PMID:17707796 MGI:6467680 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in ISO (PMID:18502753) RGD PMID:18502753 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO (PMID:19240031) RGD PMID:19240031 NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:19240031) RGD PMID:19240031 NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671 		JBrowse link
G Faf1 Fas associated factor 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977 		JBrowse link
G Faf2 Fas associated factor family member 2 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:24215460)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:24215460 GO_REF:0000024 GO_REF:0000033 NCBI chr17:9,947,211...9,989,474
Ensembl chr17:9,947,220...9,989,485 		JBrowse link
G Fbxo17 F-box protein 17 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:84,002,276...84,024,455
Ensembl chr 1:84,002,267...84,024,453 		JBrowse link
G Fbxo2 F-box protein 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:15723043)		 GO_Central
RGD		 PMID:15723043 GO_REF:0000033 NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355 		JBrowse link
G Fbxo27 F-box protein 27 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:83,965,426...83,987,781
Ensembl chr 1:83,965,986...83,987,778 		JBrowse link
G Fbxo44 F-box protein 44 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:158,583,363...158,592,510
Ensembl chr 5:158,583,366...158,592,363 		JBrowse link
G Fbxo6 F-box protein 6 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:12939278), (PMID:21062743)
(MGI:2679753|PMID:12939278), (MGI:5644019|PMID:21062743)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:12939278 PMID:21062743 GO_REF:0000024 GO_REF:0000033 MGI:2679753 MGI:5644019 NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525 		JBrowse link
G Foxred2 FAD-dependent oxidoreductase domain containing 2 involved_in IBA
ISO		 GO_REF:0000033
(PMID:19706418)		 GO_Central
RGD		 PMID:19706418 GO_REF:0000033 NCBI chr 7:109,521,761...109,538,300
Ensembl chr 7:109,521,761...109,540,874 		JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in ISO (PMID:21636303) RGD PMID:21636303 NCBI chr12:15,377,009...15,394,238
Ensembl chr12:15,377,009...15,394,053 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:28827405) RGD PMID:28827405 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:18264092)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:18264092 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein involved_in IBA
ISO		 GO_REF:0000033
(PMID:19269966)		 GO_Central
RGD		 PMID:19269966 GO_REF:0000033 NCBI chr 6:90,648,043...90,661,985
Ensembl chr 6:90,648,160...90,662,501 		JBrowse link
G Jkampl JNK1/MAPK8 associated membrane protein like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:105,520,442...105,521,542
Ensembl chr 4:105,520,442...105,521,542 		JBrowse link
G LOC120094610 derlin-1-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:2,953,829...2,955,222 JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 involved_in ISO (PMID:27108681) RGD PMID:27108681 NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824 		JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:18003979), (PMID:21062743)
(PMID:15294975)
GO_REF:0000107		 RGD
Ensembl		 PMID:15294975 PMID:18003979 PMID:21062743 GO_REF:0000107 NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910 		JBrowse link
G Nccrp1 NCCRP1, F-box associated domain containing involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:83,835,083...83,838,620
Ensembl chr 1:83,835,083...83,838,676 		JBrowse link
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in IDA
ISO		 PMID:12847084
(PMID:12847084)		 RGD PMID:12847084 PMID:12847084 RGD:10047330 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000104
(PMID:18264092), (PMID:18417469), (PMID:19346256)		 UniProt
RGD		 PMID:18264092 PMID:18417469 PMID:19346256 GO_REF:0000024 GO_REF:0000104 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055 		JBrowse link
G Rcn3 reticulocalbin 3 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:26252542)
(MGI:6201885|PMID:26252542)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:26252542 GO_REF:0000024 GO_REF:0000107 MGI:6201885 NCBI chr 1:95,564,503...95,573,762
Ensembl chr 1:95,564,380...95,573,725 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5437551|PMID:22795130)		 UniProt
RGD		 PMID:22795130 GO_REF:0000024 MGI:5437551 NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689 		JBrowse link
G Rnf103 ring finger protein 103 involved_in IBA
ISO
IEA		 GO_REF:0000033
(PMID:18675248)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:18675248 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919 		JBrowse link
G Rnf121 ring finger protein 121 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826 		JBrowse link
G Rnf139 ring finger protein 139 involved_in ISO
IBA		 (PMID:25239945)
GO_REF:0000033		 RGD
GO_Central		 PMID:25239945 GO_REF:0000033 NCBI chr 7:90,439,726...90,450,911
Ensembl chr 7:90,436,621...90,488,009 		JBrowse link
G Rnf185 ring finger protein 185 involved_in ISO
IBA
IEA		 UniProtKB:Q99942 (PMID:24019521)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:24019521 GO_REF:0000033 GO_REF:0000107 NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864 		JBrowse link
G Rnf5 ring finger protein 5 involved_in ISO
IBA		 (PMID:19269966), (PMID:24019521)
GO_REF:0000033		 RGD
GO_Central		 PMID:19269966 PMID:24019521 GO_REF:0000033 NCBI chr20:4,145,539...4,147,985
Ensembl chr20:4,145,507...4,147,985 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 acts_upstream_of_or_within IMP PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in ISO (PMID:8945469) RGD PMID:8945469 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804 		JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:5606246|PMID:25066055)
(PMID:21454652), (PMID:26471130)		 UniProt
GO_Central
RGD		 PMID:21454652 PMID:25066055 PMID:26471130 GO_REF:0000024 GO_REF:0000033 MGI:5606246 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648 		JBrowse link
G Sel1l2 SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:127,586,031...127,713,857
Ensembl chr 3:127,586,976...127,713,817 		JBrowse link
G Selenos selenoprotein S involved_in ISO (PMID:15215856) RGD PMID:15215856 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23129660)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23129660 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458 		JBrowse link
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B involved_in ISO (PMID:22607976) RGD PMID:22607976 NCBI chr 8:114,928,678...114,994,027
Ensembl chr 8:114,917,824...114,994,028 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (PMID:23990462) RGD PMID:23990462 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Syvn1 synoviolin 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (MGI:5645202|PMID:21454652)
(PMID:21454652)
GO_REF:0000033
(PMID:21245296)
(PMID:12459480), (PMID:14593114), (PMID:17059562), (PMID:22590560), (PMID:22607976), (PMID:26471130), (PMID:28827405)		 RGD
GO_Central		 PMID:12459480 PMID:14593114 PMID:17059562 PMID:21245296 PMID:21454652 More... GO_REF:0000033 MGI:5645202 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase involved_in ISO (PMID:24807418) RGD PMID:24807418 NCBI chr14:77,065,391...77,070,871
Ensembl chr14:77,065,841...77,070,865 		JBrowse link
G Tmem67 transmembrane protein 67 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19815549)		 Ensembl
RGD		 PMID:19815549 GO_REF:0000107 NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334 		JBrowse link
G Tmub1 transmembrane and ubiquitin-like domain containing 1 involved_in IEA
ISO
IBA		 GO_REF:0000107
GO_REF:0000002
(PMID:21343306)
GO_REF:0000033		 Ensembl
InterPro
RGD
GO_Central		 PMID:21343306 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:10,729,494...10,732,060
Ensembl chr 4:10,729,250...10,732,060 		JBrowse link
G Tmub2 transmembrane and ubiquitin-like domain containing 2 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:87,238,543...87,242,968
Ensembl chr10:87,238,548...87,242,779 		JBrowse link
G Tor1a torsin family 1, member A involved_in ISS
ISO		 GO_REF:0000024
(PMID:17200151)
(MGI:3712415|PMID:17200151)		 UniProt
RGD		 PMID:17200151 GO_REF:0000024 MGI:3712415 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
G Trim13 tripartite motif-containing 13 involved_in IEA
ISO
IBA		 GO_REF:0000107
(PMID:17314412)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:17314412 GO_REF:0000033 GO_REF:0000107 NCBI chr15:35,733,548...35,772,676
Ensembl chr15:35,734,107...35,772,677 		JBrowse link
G Trim25 tripartite motif-containing 25 involved_in ISO (PMID:24810856) RGD PMID:24810856 NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:22607976)
GO_REF:0000033
(PMID:11278356)		 RGD
GO_Central		 PMID:11278356 PMID:22607976 GO_REF:0000033 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:24020373)
(PMID:22607976)
(PMID:21245296)		 GO_Central
RGD		 PMID:21245296 PMID:22607976 PMID:24020373 GO_REF:0000033 NCBI chr 5:47,422,476...47,441,476
Ensembl chr 5:47,422,587...47,441,461 		JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 involved_in ISO
IBA		 (PMID:24807418)
GO_REF:0000033		 RGD
GO_Central		 PMID:24807418 GO_REF:0000033 NCBI chr 5:166,533,374...166,547,811
Ensembl chr 5:166,533,418...166,547,804 		JBrowse link
G Ube4a ubiquitination factor E4A involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:45,236,022...45,278,129
Ensembl chr 8:45,236,026...45,278,038 		JBrowse link
G Ube4b ubiquitination factor E4B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in IEA
ISO
IBA
ISS		 GO_REF:0000107
(PMID:19822669)
GO_REF:0000033
GO_REF:0000024		 Ensembl
RGD
GO_Central
UniProt		 PMID:19822669 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in IBA
ISO		 GO_REF:0000033
(PMID:24215460)		 GO_Central
RGD		 PMID:24215460 GO_REF:0000033 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505 		JBrowse link
G Ubxn10 UBX domain protein 10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:150,953,772...150,959,608
Ensembl chr 5:150,950,731...150,959,744 		JBrowse link
G Ubxn4 UBX domain protein 4 involved_in IEA
ISO
IBA
ISS		 GO_REF:0000107
(PMID:19822669)
GO_REF:0000033
GO_REF:0000024		 Ensembl
RGD
GO_Central
UniProt		 PMID:19822669 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:39,740,064...39,772,493
Ensembl chr13:39,740,107...39,772,491 		JBrowse link
G Ubxn6 UBX domain protein 6 involved_in ISO (PMID:19275885) RGD PMID:19275885 NCBI chr 9:900,883...906,047
Ensembl chr 9:900,884...906,124 		JBrowse link
G Ubxn8 UBX domain protein 8 involved_in IBA
ISO		 GO_REF:0000033
(PMID:21949850)		 GO_Central
RGD		 PMID:21949850 GO_REF:0000033 NCBI chr16:58,536,086...58,557,684
Ensembl chr16:58,536,086...58,557,684 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
IBA
IDA		 (PMID:24089527)
GO_REF:0000033
PMID:12847084		 RGD
GO_Central		 PMID:24089527 PMID:12847084 GO_REF:0000033, RGD:10047330 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467 		JBrowse link
G Umod uromodulin acts_upstream_of_or_within ISO (PMID:28437467) RGD PMID:28437467 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
G Usp19 ubiquitin specific peptidase 19 involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:19465887)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:19465887 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741 		JBrowse link
G Vcp valosin-containing protein involved_in ISS
ISO
IDA		 GO_REF:0000024
(PMID:12847084)
(PMID:17872946), (PMID:20104022), (PMID:22607976), (PMID:24089527), (PMID:24129571), (PMID:25088257), (PMID:26265139)		 UniProt
RGD		 PMID:12847084 PMID:17872946 PMID:20104022 PMID:22607976 PMID:24089527 More... GO_REF:0000024, RGD:10047330 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:20160352)
(MGI:5009360|PMID:20160352)		 RGD PMID:20160352 MGI:5009360 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Yod1 YOD1 deubiquitinase involved_in IBA
ISO
ISS		 GO_REF:0000033
(PMID:19818707)
GO_REF:0000024		 GO_Central
RGD
UniProt		 PMID:19818707 GO_REF:0000024 GO_REF:0000033 NCBI chr13:42,175,047...42,181,661
Ensembl chr13:42,174,820...42,177,205 		JBrowse link
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:144,201,604...144,227,423
Ensembl chr 3:144,201,605...144,227,485 		JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523 		JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:27108681)		 Ensembl
RGD		 PMID:27108681 GO_REF:0000107 NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824 		JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISO (MGI:5437551|PMID:22795130)
(PMID:22795130)		 RGD PMID:22795130 MGI:5437551 NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689 		JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3813160|PMID:18606867)		 UniProt
RGD		 PMID:18606867 GO_REF:0000024 MGI:3813160 NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:23129660)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:23129660 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458 		JBrowse link
G Svip small VCP interacting protein involved_in IDA
IBA
ISO
IEA		 PMID:17000876
GO_REF:0000033
(PMID:17872946)
GO_REF:0000107		 GO_Central
RGD
Ensembl		 PMID:17872946 PMID:17000876 GO_REF:0000033 GO_REF:0000107, RGD:10047192 NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116 		JBrowse link
G Ubxn1 UBX domain protein 1 involved_in ISO (PMID:21135095) RGD PMID:21135095 NCBI chr 1:205,765,309...205,769,234
Ensembl chr 1:205,745,120...205,816,520 		JBrowse link
G Ubxn2a UBX domain protein 2A involved_in ISS
ISO		 GO_REF:0000024
(PMID:26265139)		 UniProt
RGD		 PMID:26265139 GO_REF:0000024 NCBI chr 6:27,884,364...27,912,767
Ensembl chr 6:27,884,680...27,912,649
Ensembl chr20:27,884,680...27,912,649 		JBrowse link
G Usp14 ubiquitin specific peptidase 14 involved_in ISO (PMID:19135427) RGD PMID:19135427 NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519 		JBrowse link
G Usp25 ubiquitin specific peptidase 25 involved_in ISO (PMID:22590560) RGD PMID:22590560 NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348 		JBrowse link
negative regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Derl2 derlin 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Derl3 derlin 3 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Svip small VCP interacting protein involved_in ISO
IBA
IEA		 (PMID:25660456)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25660456 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:101,587,128...101,592,818
Ensembl chr 1:101,587,128...101,593,116 		JBrowse link
G Ubac2 UBA domain containing 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr15:98,960,139...99,107,795
Ensembl chr15:98,960,139...99,107,787 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 5:47,422,476...47,441,476
Ensembl chr 5:47,422,587...47,441,461 		JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO (PMID:24068323) RGD PMID:24068323 NCBI chr13:42,175,047...42,181,661
Ensembl chr13:42,174,820...42,177,205 		JBrowse link
positive regulation of ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 involved_in ISO (PMID:17000876) RGD PMID:17000876 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISO
IEA		 (PMID:24424410)
GO_REF:0000107		 RGD
Ensembl		 PMID:24424410 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO UniProtKB:Q9BUN8 (PMID:18555783) RGD PMID:18555783 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24089527)		 Ensembl
RGD		 PMID:24089527 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:18307982), (PMID:22045699) RGD PMID:18307982 PMID:22045699 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Rnf185 ring finger protein 185 involved_in ISO
IEA
ISS		 (PMID:27485036)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27485036 GO_REF:0000024 GO_REF:0000107 NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864 		JBrowse link
G Rnft1 ring finger protein, transmembrane 1 involved_in ISO
IBA		 (PMID:27485036)
GO_REF:0000033		 RGD
GO_Central		 PMID:27485036 GO_REF:0000033 NCBI chr10:71,310,052...71,322,507
Ensembl chr10:71,310,104...71,323,778 		JBrowse link
G Rnft2 ring finger protein, transmembrane 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:38,329,217...38,387,303
Ensembl chr12:38,329,269...38,387,290 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in IEA
ISO		 GO_REF:0000107
(PMID:23246001)		 Ensembl
RGD		 PMID:23246001 GO_REF:0000107 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (PMID:26265139) RGD PMID:26265139 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Tmem259 transmembrane protein 259 involved_in ISO
IBA		 (MGI:5648655|PMID:25977983)
GO_REF:0000033		 RGD
GO_Central		 PMID:25977983 GO_REF:0000033 MGI:5648655 NCBI chr 7:9,724,196...9,730,932
Ensembl chr 7:9,722,485...9,730,932 		JBrowse link
G Tmem67 transmembrane protein 67 IMP RGD PMID:19815549 RGD:8554391 NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 involved_in ISO (PMID:29932915) RGD PMID:29932915 NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18307982)		 UniProt
Ensembl
RGD		 PMID:18307982 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18307982) RGD PMID:18307982 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505 		JBrowse link
G Usp13 ubiquitin specific peptidase 13 involved_in ISO (PMID:24424410) RGD PMID:24424410 NCBI chr 2:115,576,912...115,689,153
Ensembl chr 2:115,577,091...115,686,222 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:19911006) RGD PMID:19911006 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
positive regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO (PMID:18555783) RGD PMID:18555783 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in ISO UniProtKB:Q9BV94 (PMID:24200403)
(MGI:5563002|PMID:24200403)		 RGD PMID:24200403 MGI:5563002 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in ISO UniProtKB:Q92611 (PMID:24200403)
(MGI:5563002|PMID:24200403)		 RGD PMID:24200403 MGI:5563002 NCBI chr 3:144,201,604...144,227,423
Ensembl chr 3:144,201,605...144,227,485 		JBrowse link
regulation of ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IBA		 (MGI:5613477|PMID:15147274)
(PMID:15147274)
GO_REF:0000033		 RGD
GO_Central		 PMID:15147274 GO_REF:0000033 MGI:5613477 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Usp19 ubiquitin specific peptidase 19 involved_in ISO
IEA		 (PMID:25088257)
GO_REF:0000107		 RGD
Ensembl		 PMID:25088257 GO_REF:0000107 NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741 		JBrowse link
retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in ISO
IEA		 (PMID:25660456)
GO_REF:0000107		 RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346 		JBrowse link
G Derl1 derlin 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:15215856), (PMID:25660456)
(PMID:15215855)		 RGD PMID:15215855 PMID:15215856 PMID:25660456 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Derl2 derlin 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:16449189)
MGI:4947129 (PMID:21220515)		 RGD PMID:16449189 PMID:21220515 NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480 		JBrowse link
G Faf2 Fas associated factor family member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:25660456)		 Ensembl
RGD		 PMID:25660456 GO_REF:0000107 NCBI chr17:9,947,211...9,989,474
Ensembl chr17:9,947,220...9,989,485 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 involved_in ISO
IEA		 (PMID:25660456)
GO_REF:0000107		 RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISS
ISO
EXP
IEA		 GO_REF:0000024
(PMID:12847084)
(MGI:5634892|PMID:12847084)
GO_REF:0000107
(PMID:25660456)		 ParkinsonsUK-UCL
RGD
Ensembl		 PMID:12847084 PMID:25660456 PMID:12847084 GO_REF:0000024 GO_REF:0000107 MGI:5634892, RGD:10047330 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in ISO (PMID:17215517) RGD PMID:17215517 NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804 		JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase involved_in ISO
IEA		 (PMID:25660456)
GO_REF:0000107		 RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IBA
IEA		 (PMID:15215856)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:15215856 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Syvn1 synoviolin 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase involved_in ISO (PMID:24807418) RGD PMID:24807418 NCBI chr14:77,065,391...77,070,871
Ensembl chr14:77,065,841...77,070,865 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
IEA
EXP		 (PMID:25660456)
(PMID:12847084)
GO_REF:0000107
(MGI:5634892|PMID:12847084)		 RGD
Ensembl		 PMID:12847084 PMID:25660456 PMID:12847084 GO_REF:0000107 MGI:5634892, RGD:10047330 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Vcp valosin-containing protein involved_in ISO
IBA
EXP		 (PMID:15215856), (PMID:25660456)
(PMID:12847084)
GO_REF:0000033
(MGI:5634892|PMID:12847084)		 RGD
GO_Central		 PMID:12847084 PMID:15215856 PMID:25660456 PMID:12847084 GO_REF:0000033 MGI:5634892, RGD:10047330 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    response to stimulus 10610
      response to chemical 5883
        response to nitrogen compound 1506
          ERAD pathway 106
            maintenance of unfolded protein involved in ERAD pathway 0
            negative regulation of ERAD pathway 7
            positive regulation of ERAD pathway 17
            regulation of ERAD pathway + 24
            retrograde protein transport, ER to cytosol + 27
            ubiquitin-dependent glycoprotein ERAD pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 20134
    cellular process 19326
      metabolic process 12309
        catabolic process 2821
          macromolecule catabolic process 1589
            protein catabolic process 1110
              proteolysis involved in protein catabolic process 828
                proteasomal protein catabolic process 549
                  ERAD pathway 106
                    maintenance of unfolded protein involved in ERAD pathway 0
                    negative regulation of ERAD pathway 7
                    positive regulation of ERAD pathway 17
                    regulation of ERAD pathway + 24
                    retrograde protein transport, ER to cytosol + 27
                    ubiquitin-dependent glycoprotein ERAD pathway + 4
paths to the root