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ONTOLOGY REPORT - ANNOTATIONS

Term:ERAD pathway
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Accession:GO:0036503 term browser browse the term
Definition:The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
Comment:ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
Synonyms:exact_synonym: endoplasmic reticulum-associated degradation;   protein degradation by ERAD
 related_synonym: ER-associated degradation pathway;   endoplasmic reticulum-associated protein degradation pathway


show annotations for term's descendants           Sort by:
ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO
IEA 		(PMID:11724934), (PMID:16168377), (PMID:17872946), (PMID:24810856)
GO_REF:0000107 		RGD
Ensembl		 PMID:11724934 PMID:16168377 PMID:17872946 PMID:24810856 GO_REF:0000107 NCBI chr19:11,002,451...11,038,182
Ensembl chr19:11,002,101...11,038,364 		JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:84,136,862...84,143,830
Ensembl chr 9:84,136,862...84,145,091 		JBrowse link
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in IBA
IEA
ISO
ISS 		GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
(PMID:21857022), (PMID:23223569)
GO_REF:0000024 		GO_Central
Ensembl
InterPro
RGD
UniProt		 PMID:21857022 PMID:23223569 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:117,118,035...117,121,063
Ensembl chr 4:117,117,999...117,121,061 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in IBA
ISO
ISS
IEA 		GO_REF:0000033
(PMID:23129660), (PMID:24981174), (PMID:26565908)
GO_REF:0000024
GO_REF:0000107 		GO_Central
RGD
UniProt
Ensembl		 PMID:23129660 PMID:24981174 PMID:26565908 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:3,680,607...3,693,329
Ensembl chr20:3,680,607...3,693,329 		JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISO
IEA 		(PMID:23907667)
GO_REF:0000107 		RGD
Ensembl		 PMID:23907667 GO_REF:0000107 NCBI chr 1:206,465,040...206,518,156
Ensembl chr 1:206,465,040...206,518,156 		JBrowse link
G Calr calreticulin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236 		JBrowse link
G Calr3 calreticulin 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:17,430,105...17,456,777
Ensembl chr16:17,430,153...17,457,198 		JBrowse link
G Calr4 calreticulin 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:129,216,293...129,251,077
Ensembl chr 5:129,190,608...129,251,060 		JBrowse link
G Canx calnexin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857 		JBrowse link
G Ccdc47 coiled-coil domain containing 47 involved_in
acts_upstream_of_or_within 		ISO
IEA
ISS 		(PMID:25009997)
GO_REF:0000107
MGI:3722141 (PMID:25009997)
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:25009997 GO_REF:0000024 GO_REF:0000107 NCBI chr10:91,630,101...91,648,626
Ensembl chr10:91,630,106...91,648,626 		JBrowse link
G Clgn calmegin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:41,601,568...41,633,207
Ensembl chr19:41,601,568...41,633,325 		JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:15215856), (PMID:17872946), (PMID:18555783), (PMID:24089527), (PMID:25239945) RGD PMID:15215856 PMID:17872946 PMID:18555783 PMID:24089527 PMID:25239945 NCBI chr 7:91,293,963...91,316,639
Ensembl chr 7:91,258,382...91,316,678 		JBrowse link
G Derl2 derlin 2 involved_in ISO
IEA
IBA 		(PMID:16449189)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:16449189 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr10:56,226,340...56,238,038
Ensembl chr10:56,226,219...56,237,993 		JBrowse link
G Derl3 derlin 3 involved_in ISO
IEA
IBA 		(PMID:22607976)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:22607976 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr20:12,753,926...12,766,478
Ensembl chr20:12,762,981...12,766,477 		JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 involved_in ISO
IEA 		(PMID:21148293), (PMID:21150129)
GO_REF:0000107 		RGD
Ensembl		 PMID:21148293 PMID:21150129 GO_REF:0000107 NCBI chr20:28,371,180...28,389,390
Ensembl chr20:28,371,199...28,389,389 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 involved_in ISO (PMID:15936278) RGD PMID:15936278 NCBI chr 9:84,179,702...84,187,942
Ensembl chr 9:84,179,695...84,187,942 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS
IBA
ISO 		GO_REF:0000024
GO_REF:0000033
(PMID:22267725)
(PMID:18400946) 		UniProt
GO_Central
RGD		 PMID:18400946 PMID:22267725 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000117
(PMID:18653895), (PMID:21329881)
(PMID:18400946) 		UniProt
RGD		 PMID:18400946 PMID:18653895 PMID:21329881 GO_REF:0000024 GO_REF:0000117 NCBI chr 3:85,636,890...85,679,620
Ensembl chr 3:85,639,589...85,689,368 		JBrowse link
G Ecpas Ecm29 proteasome adaptor and scaffold involved_in IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:15496406) 		GO_Central
Ensembl
RGD		 PMID:15496406 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:78,398,449...78,509,077
Ensembl chr 5:78,398,718...78,512,908 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:21062743), (PMID:25092655)
GO_REF:0000107
(PMID:11375934) 		RGD
Ensembl		 PMID:11375934 PMID:21062743 PMID:25092655 GO_REF:0000107 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060 		JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in ISO
IEA 		(PMID:15537790), (PMID:25092655)
GO_REF:0000107 		RGD
Ensembl		 PMID:15537790 PMID:25092655 GO_REF:0000107 NCBI chr 3:164,661,741...164,687,559
Ensembl chr 3:164,661,742...164,687,559 		JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 involved_in ISO
IEA 		(PMID:25092655)
GO_REF:0000117
GO_REF:0000107
(PMID:16431915) 		RGD
UniProt
Ensembl		 PMID:16431915 PMID:25092655 GO_REF:0000107 GO_REF:0000117 NCBI chr13:66,403,022...66,470,496
Ensembl chr13:66,408,590...66,472,270 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:17707796) RGD PMID:17707796 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G ENSRNOG00000066502 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000069918 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000070059 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000070668 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Erlec1 endoplasmic reticulum lectin 1 involved_in ISO
IEA 		(PMID:18502753)
GO_REF:0000002
GO_REF:0000104 		RGD
InterPro
UniProt		 PMID:18502753 GO_REF:0000002 GO_REF:0000104 NCBI chr14:108,856,661...108,894,511
Ensembl chr14:108,856,661...108,894,297 		JBrowse link
G Erlin1 ER lipid raft associated 1 involved_in ISO
IEA 		(PMID:19240031)
GO_REF:0000107 		RGD
Ensembl		 PMID:19240031 GO_REF:0000107 NCBI chr 1:252,870,356...252,905,681
Ensembl chr 1:252,870,356...252,905,947 		JBrowse link
G Erlin2 ER lipid raft associated 2 involved_in ISO (PMID:19240031) RGD PMID:19240031 NCBI chr16:71,720,486...71,736,999
Ensembl chr16:71,721,364...71,736,503 		JBrowse link
G Faf1 Fas associated factor 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:129,654,677...130,018,604
Ensembl chr 5:129,654,445...130,020,516 		JBrowse link
G Faf2 Fas associated factor family member 2 involved_in ISS
IEA
IBA
ISO 		GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:24215460) 		UniProt
Ensembl
GO_Central
RGD		 PMID:24215460 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:9,952,329...9,994,596
Ensembl chr17:9,952,329...9,994,711 		JBrowse link
G Fbxo17 F-box protein 17 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000117 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:93,129,776...93,151,983
Ensembl chr 1:93,129,849...93,151,981 		JBrowse link
G Fbxo2 F-box protein 2 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000117
(PMID:15723043) 		GO_Central
UniProt
RGD		 PMID:15723043 GO_REF:0000033 GO_REF:0000117 NCBI chr 5:163,876,079...163,881,508
Ensembl chr 5:163,875,757...163,881,508 		JBrowse link
G Fbxo27 F-box protein 27 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000117 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:93,092,900...93,115,312
Ensembl chr 1:93,093,024...93,122,181 		JBrowse link
G Fbxo44 F-box protein 44 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000117 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000117 NCBI chr 5:163,866,517...163,875,928
Ensembl chr 5:163,866,517...163,875,614 		JBrowse link
G Fbxo6 F-box protein 6 involved_in ISS
IEA
ISO
IBA 		GO_REF:0000024
GO_REF:0000117
GO_REF:0000107
(PMID:12939278), (PMID:21062743)
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:12939278 PMID:21062743 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 5:163,859,909...163,865,693
Ensembl chr 5:163,859,916...163,865,574 		JBrowse link
G Foxred2 FAD-dependent oxidoreductase domain containing 2 involved_in IBA
ISO 		GO_REF:0000033
(PMID:19706418) 		GO_Central
RGD		 PMID:19706418 GO_REF:0000033 NCBI chr 7:111,402,322...111,419,056
Ensembl chr 7:111,402,322...111,417,988 		JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in ISO (PMID:21636303) RGD PMID:21636303 NCBI chr12:20,490,861...20,508,096
Ensembl chr12:20,490,861...20,555,240 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IEA 		(PMID:28827405)
GO_REF:0000107 		RGD
Ensembl		 PMID:28827405 GO_REF:0000107 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 involved_in
NOT|involved_in 		ISS
IEA
ISO
IBA 		GO_REF:0000024
GO_REF:0000107
(PMID:24899641)
(PMID:18264092)
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:18264092 PMID:24899641 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein involved_in IBA
ISO 		GO_REF:0000033
(PMID:19269966) 		GO_Central
RGD		 PMID:19269966 GO_REF:0000033 NCBI chr 6:96,383,976...96,397,917
Ensembl chr 6:96,366,624...96,398,432 		JBrowse link
G Jkampl JNK1/MAPK8 associated membrane protein like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:107,078,531...107,079,631
Ensembl chr 4:107,077,359...107,080,150 		JBrowse link
G Man1a1 mannosidase, alpha, class 1A, member 1 involved_in ISO
IBA
IEA 		(PMID:27108681)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:27108681 GO_REF:0000033 GO_REF:0000107 NCBI chr20:33,745,158...33,928,584
Ensembl chr20:33,745,165...33,928,584 		JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:190,636,134...190,784,975
Ensembl chr 2:190,615,094...190,784,975 		JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 involved_in
acts_upstream_of_or_within 		ISO
IBA
IEA 		(PMID:18003979), (PMID:21062743)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000107
(PMID:15294975) 		RGD
GO_Central
UniProt
Ensembl		 PMID:15294975 PMID:18003979 PMID:21062743 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:28,539,778...28,563,155
Ensembl chr 3:28,541,347...28,563,154 		JBrowse link
G Man1c1 mannosidase, alpha, class 1C, member 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:152,057,839...152,197,737
Ensembl chr 5:152,057,967...152,197,138 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:84,166,570...84,243,817
Ensembl chr 2:84,166,570...84,243,792 		JBrowse link
G Nccrp1 NCCRP1, F-box associated domain containing involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:92,962,618...92,966,155
Ensembl chr 1:92,962,618...92,966,410 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in IDA
ISO 		PMID:12847084
(PMID:12847084) 		RGD PMID:12847084 PMID:12847084 RGD:10047330 NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
GO_REF:0000002
(PMID:18264092), (PMID:18417469), (PMID:19346256), (PMID:24899641)
GO_REF:0000104 		UniProt
Ensembl
InterPro
RGD		 PMID:18264092 PMID:18417469 PMID:19346256 PMID:24899641 GO_REF:0000002 GO_REF:0000024 GO_REF:0000104 GO_REF:0000107 NCBI chr 7:64,802,517...64,829,185
Ensembl chr 7:64,802,103...64,829,070 		JBrowse link
G Rcn3 reticulocalbin 3 involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:26252542)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:26252542 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:104,700,969...104,710,228
Ensembl chr 1:104,700,545...104,710,249 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:22795130) 		UniProt
Ensembl
RGD		 PMID:22795130 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:91,076,786...91,196,719
Ensembl chr 9:91,078,210...91,196,850 		JBrowse link
G Rnf103 ring finger protein 103 involved_in IBA
ISO
IEA 		GO_REF:0000033
(PMID:18675248)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:18675248 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:105,084,762...105,100,839
Ensembl chr 4:105,084,686...105,106,809 		JBrowse link
G Rnf121 ring finger protein 121 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:165,789,356...165,858,832
Ensembl chr 1:165,789,360...165,858,884 		JBrowse link
G Rnf139 ring finger protein 139 involved_in ISO
IEA
IBA 		(PMID:25239945)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:25239945 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:92,329,201...92,340,386
Ensembl chr 7:92,329,157...92,341,721 		JBrowse link
G Rnf145 ring finger protein 145 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,507,772...29,552,151 		JBrowse link
G Rnf185 ring finger protein 185 involved_in ISO
IBA
IEA 		UniProtKB:Q99942 (PMID:24019521)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:24019521 GO_REF:0000033 GO_REF:0000107 NCBI chr14:82,516,153...82,554,199
Ensembl chr14:82,516,154...82,553,466 		JBrowse link
G Rnf5 ring finger protein 5 involved_in ISO
IEA
IBA 		(PMID:19269966), (PMID:24019521)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:19269966 PMID:24019521 GO_REF:0000033 GO_REF:0000107 NCBI chr20:4,150,032...4,152,593
Ensembl chr20:4,150,138...4,152,591 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 acts_upstream_of_or_within IMP PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:97,376,878...97,379,120
Ensembl chr11:97,376,878...97,379,120 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in ISO
IEA 		(PMID:8945469)
GO_REF:0000107 		RGD
Ensembl		 PMID:8945469 GO_REF:0000107 NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:66,569,196...66,580,028 		JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase involved_in ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:21454652), (PMID:26471130), (PMID:37943610), (PMID:37943617)
GO_REF:0000117
GO_REF:0000107
(PMID:25066055)
GO_REF:0000033 		UniProt
RGD
Ensembl
GO_Central		 PMID:21454652 PMID:25066055 PMID:26471130 PMID:37943610 PMID:37943617 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:116,466,163...116,510,436
Ensembl chr 6:116,466,163...116,510,578 		JBrowse link
G Sel1l2 SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:148,040,624...148,167,490
Ensembl chr 3:148,040,516...148,167,462 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA 		(PMID:15215856)
GO_REF:0000107 		RGD
Ensembl		 PMID:15215856 GO_REF:0000107 NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:129,070,230...129,077,991 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in ISS
ISO 		GO_REF:0000024
(PMID:23129660) 		UniProt
RGD		 PMID:23129660 GO_REF:0000024 NCBI chr 7:9,304,381...9,321,157
Ensembl chr 7:9,304,197...9,321,669 		JBrowse link
G Sik2 salt-inducible kinase 2 acts_upstream_of_or_within ISO (PMID:24129571) RGD PMID:24129571 NCBI chr 8:60,121,913...60,221,707
Ensembl chr 8:60,121,913...60,221,818 		JBrowse link
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B involved_in ISO (PMID:22607976) RGD PMID:22607976 NCBI chr 8:123,806,836...123,872,179
Ensembl chr 8:123,795,983...123,872,180 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO
IEA 		(PMID:23990462)
GO_REF:0000107 		RGD
Ensembl		 PMID:23990462 GO_REF:0000107 NCBI chr10:15,355,278...15,357,559
Ensembl chr10:15,355,279...15,357,559 		JBrowse link
G Syvn1 synoviolin 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:12459480), (PMID:14593114), (PMID:17059562), (PMID:22590560), (PMID:22607976), (PMID:26471130), (PMID:28827405)
GO_REF:0000107
GO_REF:0000033
(PMID:21454652)
(PMID:21245296) 		RGD
Ensembl
GO_Central		 PMID:12459480 PMID:14593114 PMID:17059562 PMID:21245296 PMID:21454652 More... GO_REF:0000033 GO_REF:0000107 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457 		JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase involved_in ISO
IEA 		(PMID:24807418)
GO_REF:0000107 		RGD
Ensembl		 PMID:24807418 GO_REF:0000107 NCBI chr14:81,289,852...81,295,416
Ensembl chr14:81,290,351...81,295,417 		JBrowse link
G Tmem67 transmembrane protein 67 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19815549) 		Ensembl
RGD		 PMID:19815549 GO_REF:0000107 NCBI chr 5:30,333,793...30,386,702
Ensembl chr 5:30,333,793...30,386,666 		JBrowse link
G Tmub1 transmembrane and ubiquitin-like domain containing 1 involved_in IEA
ISO
IBA 		GO_REF:0000107
GO_REF:0000002
(PMID:21343306)
GO_REF:0000033 		Ensembl
InterPro
RGD
GO_Central		 PMID:21343306 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:11,621,931...11,624,497
Ensembl chr 4:11,621,508...11,624,499 		JBrowse link
G Tmub2 transmembrane and ubiquitin-like domain containing 2 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr10:87,738,662...87,743,118
Ensembl chr10:87,738,698...87,742,933 		JBrowse link
G Tor1a torsin family 1, member A involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:17200151) 		UniProt
Ensembl
RGD		 PMID:17200151 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:34,648,421...34,655,453
Ensembl chr 3:34,648,422...34,655,417 		JBrowse link
G Trim13 tripartite motif-containing 13 involved_in IEA
ISO
IBA 		GO_REF:0000107
(PMID:17314412)
GO_REF:0000033 		Ensembl
RGD
GO_Central		 PMID:17314412 GO_REF:0000033 GO_REF:0000107 NCBI chr15:39,909,587...39,948,719
Ensembl chr15:39,902,284...39,958,892 		JBrowse link
G Trim25 tripartite motif-containing 25 involved_in ISO
IEA 		(PMID:24810856)
GO_REF:0000107 		RGD
Ensembl		 PMID:24810856 GO_REF:0000107 NCBI chr10:74,310,024...74,328,473
Ensembl chr10:74,310,022...74,331,716 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:22607976)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033
(PMID:11278356) 		RGD
UniProt
Ensembl
GO_Central		 PMID:11278356 PMID:22607976 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr20:10,983,322...11,005,060
Ensembl chr20:10,983,325...11,005,187 		JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000117
GO_REF:0000107
(PMID:24020373)
(PMID:22607976)
(PMID:21245296) 		GO_Central
UniProt
Ensembl
RGD		 PMID:21245296 PMID:22607976 PMID:24020373 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 5:52,218,807...52,237,805
Ensembl chr 5:52,218,807...52,237,805 		JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 involved_in ISO
IEA
IBA 		(PMID:24807418)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:24807418 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:171,815,607...171,830,037
Ensembl chr 5:171,815,623...171,830,034 		JBrowse link
G Ube4a ubiquitination factor E4A involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:54,132,799...54,174,921
Ensembl chr 8:54,132,801...54,174,835 		JBrowse link
G Ube4b ubiquitination factor E4B involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:165,049,897...165,153,572
Ensembl chr 5:165,049,897...165,153,572 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in IEA
ISO
IBA
ISS 		GO_REF:0000107
(PMID:19822669)
GO_REF:0000033
GO_REF:0000024 		Ensembl
RGD
GO_Central
UniProt		 PMID:19822669 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:6,438,456...6,482,498
Ensembl chr17:6,444,124...6,482,499 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in IBA
ISO 		GO_REF:0000033
(PMID:24215460) 		GO_Central
RGD		 PMID:24215460 GO_REF:0000033 NCBI chr  X:21,228,809...21,232,228
Ensembl chr  X:21,229,197...21,232,268 		JBrowse link
G Ubxn10 UBX domain protein 10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:156,237,041...156,242,877
Ensembl chr 5:156,216,565...156,243,741 		JBrowse link
G Ubxn4 UBX domain protein 4 involved_in IEA
ISO
IBA
ISS 		GO_REF:0000107
(PMID:19822669)
GO_REF:0000033
GO_REF:0000024 		Ensembl
RGD
GO_Central
UniProt		 PMID:19822669 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr13:42,292,346...42,324,928
Ensembl chr13:42,292,528...42,326,143 		JBrowse link
G Ubxn6 UBX domain protein 6 involved_in ISO
IEA 		(PMID:19275885)
GO_REF:0000107 		RGD
Ensembl		 PMID:19275885 GO_REF:0000107 NCBI chr 9:988,051...993,221
Ensembl chr 9:988,051...993,497 		JBrowse link
G Ubxn8 UBX domain protein 8 involved_in ISO
IEA 		(PMID:21949850)
GO_REF:0000002 		RGD
InterPro		 PMID:21949850 GO_REF:0000002 NCBI chr16:65,239,149...65,260,743
Ensembl chr16:65,240,062...65,260,639 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
IEA
IBA
IDA 		(PMID:24089527)
GO_REF:0000107
(PMID:12847084)
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:12847084 PMID:24089527 PMID:12847084 GO_REF:0000033 GO_REF:0000107, RGD:10047330 NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434 		JBrowse link
G Umod uromodulin acts_upstream_of_or_within ISO
IEA 		(PMID:28437467)
GO_REF:0000107 		RGD
Ensembl		 PMID:28437467 GO_REF:0000107 NCBI chr 1:183,247,676...183,261,665
Ensembl chr 1:183,247,674...183,261,030 		JBrowse link
G Usp19 ubiquitin specific peptidase 19 involved_in ISS
IBA
ISO
IEA 		GO_REF:0000024
GO_REF:0000033
(PMID:19465887)
GO_REF:0000107 		UniProt
GO_Central
RGD
Ensembl		 PMID:19465887 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:118,069,227...118,080,283
Ensembl chr 8:118,069,240...118,080,300 		JBrowse link
G Vcp valosin-containing protein involved_in ISS
IEA
ISO
IDA 		GO_REF:0000024
GO_REF:0000107
(PMID:12847084)
(PMID:17872946), (PMID:20104022), (PMID:22607976), (PMID:24089527), (PMID:24129571), (PMID:25088257), (PMID:26265139) 		UniProt
Ensembl
RGD		 PMID:12847084 PMID:17872946 PMID:20104022 PMID:22607976 PMID:24089527 More... GO_REF:0000024 GO_REF:0000107, RGD:10047330 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO
IEA 		(PMID:20160352)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:20160352 GO_REF:0000107 GO_REF:0000117 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:78,034,864...78,060,459 		JBrowse link
G Yod1 YOD1 deubiquitinase involved_in IBA
ISO
ISS 		GO_REF:0000033
(PMID:19818707)
GO_REF:0000024 		GO_Central
RGD
UniProt		 PMID:19818707 GO_REF:0000024 GO_REF:0000033 NCBI chr13:44,727,319...44,733,933 JBrowse link
G Zdhhc9 zinc finger DHHC-type palmitoyltransferase 9 acts_upstream_of_or_within ISO (PMID:12459480) RGD PMID:12459480 NCBI chr  X:132,230,243...132,266,139
Ensembl chr  X:132,230,245...132,266,139 		JBrowse link
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Man1a1 mannosidase, alpha, class 1A, member 1 involved_in ISO (PMID:27108681) RGD PMID:27108681 NCBI chr20:33,745,158...33,928,584
Ensembl chr20:33,745,165...33,928,584 		JBrowse link
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hm13 histocompatibility minor 13 involved_in ISO
IEA 		(PMID:25239945)
GO_REF:0000107 		RGD
Ensembl		 PMID:25239945 GO_REF:0000107 NCBI chr 3:161,606,059...161,641,382
Ensembl chr 3:161,606,052...161,644,805 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISO
IEA 		(PMID:22795130)
GO_REF:0000107 		RGD
Ensembl		 PMID:22795130 GO_REF:0000107 NCBI chr 9:91,076,786...91,196,719
Ensembl chr 9:91,078,210...91,196,850 		JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 involved_in ISS
ISO 		GO_REF:0000024
(PMID:18606867) 		UniProt
RGD		 PMID:18606867 GO_REF:0000024 NCBI chr 1:161,457,752...161,467,918
Ensembl chr 1:161,457,754...161,467,945 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in ISS
ISO 		GO_REF:0000024
(PMID:23129660) 		UniProt
RGD		 PMID:23129660 GO_REF:0000024 NCBI chr 7:9,304,381...9,321,157
Ensembl chr 7:9,304,197...9,321,669 		JBrowse link
G Svip small VCP interacting protein involved_in IDA
IBA
ISO 		PMID:17000876
GO_REF:0000033
(PMID:17872946) 		GO_Central
RGD		 PMID:17872946 PMID:17000876 GO_REF:0000033, RGD:10047192 NCBI chr 1:110,723,051...110,728,741
Ensembl chr 1:110,723,051...110,729,075 		JBrowse link
G Ubxn1 UBX domain protein 1 involved_in ISO (PMID:21135095) RGD PMID:21135095 NCBI chr 1:215,194,418...215,198,343
Ensembl chr 1:215,174,216...215,198,343 		JBrowse link
G Ubxn2a UBX domain protein 2A involved_in ISS
ISO 		GO_REF:0000024
(PMID:26265139) 		UniProt
RGD		 PMID:26265139 GO_REF:0000024 NCBI chr 6:33,603,804...33,645,958
Ensembl chr 6:33,603,804...33,632,202
Ensembl chr20:33,603,804...33,632,202 		JBrowse link
G Usp14 ubiquitin specific peptidase 14 involved_in ISO
IBA 		(PMID:19135427)
GO_REF:0000033 		RGD
GO_Central		 PMID:19135427 GO_REF:0000033 NCBI chr18:1,292,745...1,330,867
Ensembl chr18:1,292,745...1,330,336 		JBrowse link
G Usp25 ubiquitin specific peptidase 25 involved_in ISO
IEA 		(PMID:22590560)
GO_REF:0000107 		RGD
Ensembl		 PMID:22590560 GO_REF:0000107 NCBI chr11:29,088,283...29,198,323
Ensembl chr11:29,087,736...29,198,323 		JBrowse link
negative regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Derl2 derlin 2 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr10:56,226,340...56,238,038
Ensembl chr10:56,226,219...56,237,993 		JBrowse link
G Derl3 derlin 3 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr20:12,753,926...12,766,478
Ensembl chr20:12,762,981...12,766,477 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in ISO (PMID:25660456) RGD PMID:25660456 NCBI chr14:108,856,661...108,894,511
Ensembl chr14:108,856,661...108,894,297 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 7:64,802,517...64,829,185
Ensembl chr 7:64,802,103...64,829,070 		JBrowse link
G Svip small VCP interacting protein involved_in ISO
IBA 		(PMID:25660456)
GO_REF:0000033 		RGD
GO_Central		 PMID:25660456 GO_REF:0000033 NCBI chr 1:110,723,051...110,728,741
Ensembl chr 1:110,723,051...110,729,075 		JBrowse link
G Ubac2 UBA domain containing 2 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr15:105,366,776...105,514,435
Ensembl chr15:105,366,697...105,514,444 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr20:10,983,322...11,005,060
Ensembl chr20:10,983,325...11,005,187 		JBrowse link
G Ube2j1 ubiquitin-conjugating enzyme E2, J1 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 5:52,218,807...52,237,805
Ensembl chr 5:52,218,807...52,237,805 		JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO (PMID:24068323) RGD PMID:24068323 NCBI chr13:44,727,319...44,733,933 JBrowse link
positive regulation of ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 involved_in ISO
IBA
IEA 		(PMID:17000876)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:17000876 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:126,837,107...126,872,919
Ensembl chr 6:126,839,327...126,872,781 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISO
IEA 		(PMID:24424410)
GO_REF:0000107 		RGD
Ensembl		 PMID:24424410 GO_REF:0000107 NCBI chr20:3,680,607...3,693,329
Ensembl chr20:3,680,607...3,693,329 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO
IEA 		UniProtKB:Q9BUN8 (PMID:18555783)
GO_REF:0000107 		RGD
Ensembl		 PMID:18555783 GO_REF:0000107 NCBI chr  X:156,548,911...156,581,002
Ensembl chr  X:156,548,911...156,579,371 		JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:24089527) 		Ensembl
RGD		 PMID:24089527 GO_REF:0000107 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IEA 		(PMID:18307982), (PMID:22045699)
GO_REF:0000107 		RGD
Ensembl		 PMID:18307982 PMID:22045699 GO_REF:0000107 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Rnf185 ring finger protein 185 involved_in ISO
IEA
ISS 		(PMID:27485036)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:27485036 GO_REF:0000024 GO_REF:0000107 NCBI chr14:82,516,153...82,554,199
Ensembl chr14:82,516,154...82,553,466 		JBrowse link
G Rnft1 ring finger protein, transmembrane 1 involved_in ISO
IEA
IBA 		(PMID:27485036)
GO_REF:0000002
GO_REF:0000033 		RGD
InterPro
GO_Central		 PMID:27485036 GO_REF:0000002 GO_REF:0000033 NCBI chr10:71,807,403...71,821,132
Ensembl chr10:71,807,456...71,821,141 		JBrowse link
G Rnft2 ring finger protein, transmembrane 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:43,990,113...44,048,215
Ensembl chr12:43,990,304...44,048,213 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in ISO (PMID:23246001) RGD PMID:23246001 NCBI chr 7:9,304,381...9,321,157
Ensembl chr 7:9,304,197...9,321,669 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO
IEA 		(PMID:26265139)
GO_REF:0000107 		RGD
Ensembl		 PMID:26265139 GO_REF:0000107 NCBI chr10:15,355,278...15,357,559
Ensembl chr10:15,355,279...15,357,559 		JBrowse link
G Tmem259 transmembrane protein 259 involved_in IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:25977983) 		GO_Central
Ensembl
RGD		 PMID:25977983 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:10,374,804...10,381,566
Ensembl chr 7:10,373,119...10,381,566 		JBrowse link
G Tmem67 transmembrane protein 67 IMP RGD PMID:19815549 RGD:8554391 NCBI chr 5:30,333,793...30,386,702
Ensembl chr 5:30,333,793...30,386,666 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 involved_in ISO
IEA 		(PMID:29932915)
GO_REF:0000107 		RGD
Ensembl		 PMID:29932915 GO_REF:0000107 NCBI chr 6:94,696,699...94,707,751
Ensembl chr 6:94,696,358...94,708,618 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:18307982) 		UniProt
Ensembl
RGD		 PMID:18307982 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,438,456...6,482,498
Ensembl chr17:6,444,124...6,482,499 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18307982) RGD PMID:18307982 NCBI chr  X:21,228,809...21,232,228
Ensembl chr  X:21,229,197...21,232,268 		JBrowse link
G Usp13 ubiquitin specific peptidase 13 involved_in ISO (PMID:24424410) RGD PMID:24424410 NCBI chr 2:117,502,811...117,617,049
Ensembl chr 2:117,505,122...117,630,161 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO
IEA 		(PMID:19911006)
GO_REF:0000107 		RGD
Ensembl		 PMID:19911006 GO_REF:0000107 NCBI chr14:78,035,205...78,059,718
Ensembl chr14:78,034,864...78,060,459 		JBrowse link
G Xbp1 X-box binding protein 1 acts_upstream_of_or_within ISO (PMID:19911006) RGD PMID:19911006 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
positive regulation of retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO
IEA 		(PMID:18555783)
GO_REF:0000107 		RGD
Ensembl		 PMID:18555783 GO_REF:0000107 NCBI chr  X:156,548,911...156,581,002
Ensembl chr  X:156,548,911...156,579,371 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in ISO
IEA 		UniProtKB:Q9BV94 (PMID:24200403)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:24200403 GO_REF:0000107 GO_REF:0000117 NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060 		JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in ISO
IEA 		UniProtKB:Q92611 (PMID:24200403)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:24200403 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:164,661,741...164,687,559
Ensembl chr 3:164,661,742...164,687,559 		JBrowse link
regulation of ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in IBA
ISO 		GO_REF:0000033
(PMID:15147274) 		GO_Central
RGD		 PMID:15147274 GO_REF:0000033 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Usp19 ubiquitin specific peptidase 19 involved_in ISO
IEA 		(PMID:25088257)
GO_REF:0000107 		RGD
Ensembl		 PMID:25088257 GO_REF:0000107 NCBI chr 8:118,069,227...118,080,283
Ensembl chr 8:118,069,240...118,080,300 		JBrowse link
retrograde protein transport, ER to cytosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afg2b AFG2 AAA ATPase homolog B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:130,148,061...130,162,458
Ensembl chr 3:130,148,301...130,162,112 		JBrowse link
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 4:117,118,035...117,121,063
Ensembl chr 4:117,117,999...117,121,061 		JBrowse link
G Derl1 derlin 1 involved_in
acts_upstream_of_or_within 		ISO (PMID:15215856), (PMID:25660456)
(PMID:15215855) 		RGD PMID:15215855 PMID:15215856 PMID:25660456 NCBI chr 7:91,293,963...91,316,639
Ensembl chr 7:91,258,382...91,316,678 		JBrowse link
G Derl2 derlin 2 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:16449189)
GO_REF:0000107
MGI:4947129 (PMID:21220515) 		RGD
Ensembl		 PMID:16449189 PMID:21220515 GO_REF:0000107 NCBI chr10:56,226,340...56,238,038
Ensembl chr10:56,226,219...56,237,993 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:108,856,661...108,894,511
Ensembl chr14:108,856,661...108,894,297 		JBrowse link
G Faf2 Fas associated factor family member 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:25660456) 		Ensembl
RGD		 PMID:25660456 GO_REF:0000107 NCBI chr17:9,952,329...9,994,596
Ensembl chr17:9,952,329...9,994,711 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISS
IEA
ISO
EXP 		GO_REF:0000024
GO_REF:0000117
(PMID:12847084)
GO_REF:0000107
(PMID:25660456) 		ParkinsonsUK-UCL
UniProt
RGD
Ensembl		 PMID:12847084 PMID:25660456 PMID:12847084 GO_REF:0000024 GO_REF:0000107 GO_REF:0000117, RGD:10047330 NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:64,802,517...64,829,185
Ensembl chr 7:64,802,103...64,829,070 		JBrowse link
G Sec61b SEC61 translocon subunit beta involved_in ISO
IEA 		(PMID:17215517)
GO_REF:0000107 		RGD
Ensembl		 PMID:17215517 GO_REF:0000107 NCBI chr 5:66,569,184...66,577,394
Ensembl chr 5:66,569,196...66,580,028 		JBrowse link
G Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 6:116,466,163...116,510,436
Ensembl chr 6:116,466,163...116,510,578 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IBA
IEA 		(PMID:15215856)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:15215856 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:129,070,230...129,077,991 		JBrowse link
G Syvn1 synoviolin 1 involved_in ISO
IEA 		(PMID:25660456)
GO_REF:0000107 		RGD
Ensembl		 PMID:25660456 GO_REF:0000107 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457 		JBrowse link
G Tmem129 transmembrane protein 129, E3 ubiquitin ligase involved_in ISO
IEA 		(PMID:24807418)
GO_REF:0000107 		RGD
Ensembl		 PMID:24807418 GO_REF:0000107 NCBI chr14:81,289,852...81,295,416
Ensembl chr14:81,290,351...81,295,417 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
IEA
EXP 		(PMID:25660456)
GO_REF:0000117
(PMID:12847084)
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:12847084 PMID:25660456 PMID:12847084 GO_REF:0000107 GO_REF:0000117, RGD:10047330 NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434 		JBrowse link
G Vcp valosin-containing protein involved_in ISO
IEA
IBA
EXP 		(PMID:15215856), (PMID:25660456)
GO_REF:0000117
GO_REF:0000107
(PMID:12847084)
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:12847084 PMID:15215856 PMID:25660456 PMID:12847084 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:10047330 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387 		JBrowse link
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:66,403,022...66,470,496
Ensembl chr13:66,408,590...66,472,270 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    response to stimulus 11199
      response to chemical 6040
        response to nitrogen compound 1587
          ERAD pathway 113
            maintenance of unfolded protein involved in ERAD pathway 0
            negative regulation of ERAD pathway 7
            positive regulation of ERAD pathway 18
            regulation of ERAD pathway + 25
            retrograde protein transport, ER to cytosol + 28
            ubiquitin-dependent glycoprotein ERAD pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        catabolic process 3065
          macromolecule catabolic process 1777
            protein catabolic process 1269
              proteolysis involved in protein catabolic process 997
                proteasomal protein catabolic process 702
                  ERAD pathway 113
                    maintenance of unfolded protein involved in ERAD pathway 0
                    negative regulation of ERAD pathway 7
                    positive regulation of ERAD pathway 18
                    regulation of ERAD pathway + 25
                    retrograde protein transport, ER to cytosol + 28
                    ubiquitin-dependent glycoprotein ERAD pathway + 2
paths to the root