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ONTOLOGY REPORT - ANNOTATIONS


Term:ATF6-mediated unfolded protein response
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Accession:GO:0036500 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
Synonyms:exact_synonym: ATF6 branch of UPR;   UPR signaling by ATF6 stress sensor;   activating transcription factor 6 signaling in unfolded protein response;   endoplasmic reticulum unfolded protein response; ATF6 signaling
 narrow_synonym: ATF6-alpha UPR branch;   ATF6-beta UPR branch
 broad_synonym: ATF6 signal transduction pathway
 related_synonym: ATF6 signaling in response to endoplasmic reticulum stress



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negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:34,647,146...34,655,074
Ensembl chr17:34,647,146...34,655,074
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO MGI GO_REF:0000096 MGI:4417868 MGI:4834177 NCBI chr 5:36,966,104...36,988,982
Ensembl chr 5:36,966,104...36,989,205
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 29905
    cellular process 17662
      signal transduction 6551
        endoplasmic reticulum unfolded protein response 70
          ATF6-mediated unfolded protein response 3
            negative regulation of ATF6-mediated unfolded protein response 2
            positive regulation of ATF6-mediated unfolded protein response 1
            regulation of ATF6-mediated unfolded protein response + 3
Path 2
Term Annotations click to browse term
  biological_process 29905
    response to stimulus 10529
      response to chemical 5509
        cellular response to chemical stimulus 3704
          cellular response to organic substance 3019
            cellular response to topologically incorrect protein 111
              cellular response to unfolded protein 91
                endoplasmic reticulum unfolded protein response 70
                  ATF6-mediated unfolded protein response 3
                    negative regulation of ATF6-mediated unfolded protein response 2
                    positive regulation of ATF6-mediated unfolded protein response 1
                    regulation of ATF6-mediated unfolded protein response + 3
paths to the root