Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:ATF6-mediated unfolded protein response
go back to main search page
Accession:GO:0036500 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
Synonyms:exact_synonym: ATF6 branch of UPR;   UPR signaling by ATF6 stress sensor;   activating transcription factor 6 signaling in unfolded protein response;   endoplasmic reticulum unfolded protein response; ATF6 signaling
 narrow_synonym: ATF6-alpha UPR branch;   ATF6-beta UPR branch
 broad_synonym: ATF6 signal transduction pathway
 related_synonym: ATF6 signaling in response to endoplasmic reticulum stress



show annotations for term's descendants           Sort by:
 
ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
JBrowse link
G ATF6B activating transcription factor 6 beta involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253
JBrowse link
G DDIT3 DNA damage inducible transcript 3 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G MBTPS1 membrane bound transcription factor peptidase, site 1 involved_in TAS (PMID:22934019) Reactome PMID:22934019 Reactome:R-HSA-381033 NCBI chr16:84,053,763...84,116,942
Ensembl chr16:84,053,761...84,116,942
JBrowse link
G MBTPS2 membrane bound transcription factor peptidase, site 2 involved_in TAS (PMID:22934019) Reactome PMID:22934019 Reactome:R-HSA-381033 NCBI chr  X:21,839,617...21,885,423
Ensembl chr  X:21,839,617...21,885,423
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in IDA (PMID:9837962) UniProt PMID:9837962 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IDA (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 NCBI chr 4:6,260,368...6,303,265
Ensembl chr 4:6,269,849...6,303,265
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in IDA (PMID:9837962) UniProt PMID:9837962 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
JBrowse link
regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in TAS (PMID:22934019) ParkinsonsUK-UCL PMID:22934019 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18539
    cellular process 17460
      signal transduction 6276
        endoplasmic reticulum unfolded protein response 81
          ATF6-mediated unfolded protein response 7
            negative regulation of ATF6-mediated unfolded protein response 2
            positive regulation of ATF6-mediated unfolded protein response 1
            regulation of ATF6-mediated unfolded protein response + 4
Path 2
Term Annotations click to browse term
  biological_process 18539
    response to stimulus 9789
      response to chemical 5362
        cellular response to chemical stimulus 3684
          cellular response to organic substance 3004
            cellular response to topologically incorrect protein 125
              cellular response to unfolded protein 105
                endoplasmic reticulum unfolded protein response 81
                  ATF6-mediated unfolded protein response 7
                    negative regulation of ATF6-mediated unfolded protein response 2
                    positive regulation of ATF6-mediated unfolded protein response 1
                    regulation of ATF6-mediated unfolded protein response + 4
paths to the root