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ONTOLOGY REPORT - ANNOTATIONS


Term:ATF6-mediated unfolded protein response
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Accession:GO:0036500 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
Synonyms:exact_synonym: ATF6 branch of UPR;   UPR signaling by ATF6 stress sensor;   activating transcription factor 6 signaling in unfolded protein response;   endoplasmic reticulum unfolded protein response; ATF6 signaling
 narrow_synonym: ATF6-alpha UPR branch;   ATF6-beta UPR branch
 broad_synonym: ATF6 signal transduction pathway
 related_synonym: ATF6 signaling in response to endoplasmic reticulum stress



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negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chr12:1,515,186...1,525,165
Ensembl chr12:1,515,503...1,525,110
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 RGD:10047363 NCBI chr13:38,451,722...38,466,481
Ensembl chr13:38,451,710...38,475,827
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chr38:20,705,167...20,903,852
Ensembl chr38:20,709,038...20,903,814
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13874
    cellular process 13118
      signal transduction 4417
        endoplasmic reticulum unfolded protein response 66
          ATF6-mediated unfolded protein response 3
            negative regulation of ATF6-mediated unfolded protein response 2
            positive regulation of ATF6-mediated unfolded protein response 1
            regulation of ATF6-mediated unfolded protein response + 3
Path 2
Term Annotations click to browse term
  biological_process 13874
    response to stimulus 7417
      response to chemical 4322
        cellular response to chemical stimulus 3177
          cellular response to organic substance 2624
            cellular response to topologically incorrect protein 100
              cellular response to unfolded protein 83
                endoplasmic reticulum unfolded protein response 66
                  ATF6-mediated unfolded protein response 3
                    negative regulation of ATF6-mediated unfolded protein response 2
                    positive regulation of ATF6-mediated unfolded protein response 1
                    regulation of ATF6-mediated unfolded protein response + 3
paths to the root