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ONTOLOGY REPORT - ANNOTATIONS


Term:ATF6-mediated unfolded protein response
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Accession:GO:0036500 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
Synonyms:exact_synonym: ATF6 branch of UPR;   UPR signaling by ATF6 stress sensor;   activating transcription factor 6 signaling in unfolded protein response;   endoplasmic reticulum unfolded protein response; ATF6 signaling
 narrow_synonym: ATF6-alpha UPR branch;   ATF6-beta UPR branch
 broad_synonym: ATF6 signal transduction pathway
 related_synonym: ATF6 signaling in response to endoplasmic reticulum stress


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negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955437:582,083...592,026
Ensembl chrNW_004955437:582,431...591,810
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G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 RGD:10047363 NCBI chrNW_004955514:3,902,508...3,924,281
Ensembl chrNW_004955514:3,902,454...3,924,610
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955462:14,352,956...14,553,299
Ensembl chrNW_004955462:14,357,945...14,548,543
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11981
    cellular process 11217
      signal transduction 3790
        endoplasmic reticulum unfolded protein response 59
          ATF6-mediated unfolded protein response 3
            negative regulation of ATF6-mediated unfolded protein response 2
            positive regulation of ATF6-mediated unfolded protein response 1
            regulation of ATF6-mediated unfolded protein response + 3
Path 2
Term Annotations click to browse term
  biological_process 11981
    response to stimulus 6456
      response to chemical 3773
        cellular response to chemical stimulus 2745
          cellular response to organic substance 2251
            cellular response to topologically incorrect protein 85
              cellular response to unfolded protein 70
                endoplasmic reticulum unfolded protein response 59
                  ATF6-mediated unfolded protein response 3
                    negative regulation of ATF6-mediated unfolded protein response 2
                    positive regulation of ATF6-mediated unfolded protein response 1
                    regulation of ATF6-mediated unfolded protein response + 3
paths to the root