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ONTOLOGY REPORT - ANNOTATIONS


Term:IRE1-mediated unfolded protein response
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Accession:GO:0036498 term browser browse the term
Definition:A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Comment:Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
Synonyms:exact_synonym: IRE1 branch of UPR;   UPR signaling by IRE1 stress sensor;   endoplasmic reticulum unfolded protein response; IRE1 signaling
 narrow_synonym: IRE1alpha unfolded protein response;   IRE1p unfolded protein response
 broad_synonym: IRE1 signal transduction pathway
 related_synonym: ERN1-mediated unfolded protein response;   IRE1 signaling in response to endoplasmic reticulum stress;   inositol-requiring enzyme 1-mediated unfolded protein response;   inositol-requiring transmembrane kinase/endonuclease signal transduction


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IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in IBA
ISO
PMID:21873635
(MGI:5571560|PMID:24508390), (MGI:6114871|PMID:25164867)
(PMID:11779465), (PMID:19328063), (PMID:28128204), (PMID:29198525), (PMID:9637683)
RGD PMID:9637683 PMID:11779465 PMID:19328063 PMID:24508390 PMID:25164867 PMID:28128204 PMID:29198525, PMID:21873635 MGI:5571560 MGI:6114871, RGD:13792537 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:192,126,023...192,142,865
Ensembl chr 1:192,126,023...192,142,854
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IEA
(PMID:23103912)
GO_REF:0000107
RGD
Ensembl
PMID:23103912 GO_REF:0000107 NCBI chr 8:70,712,393...70,731,212
Ensembl chr 8:70,708,873...70,729,985
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (MGI:5616322|PMID:15465829) RGD PMID:15465829 MGI:5616322 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS
(PMID:20940299)
GO_REF:0000024
RGD
UniProt
PMID:20940299 GO_REF:0000024 NCBI chr 3:171,832,558...171,871,042
Ensembl chr 3:171,832,500...171,868,647
JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:28128204), (PMID:32160526)
(MGI:5912977|PMID:28128204)
RGD PMID:28128204 PMID:32160526 MGI:5912977 NCBI chr 3:123,195,580...123,206,828
Ensembl chr 3:123,195,580...123,206,828
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
ISS
(PMID:32160526)
GO_REF:0000024
RGD
UniProt
PMID:32160526 GO_REF:0000024 NCBI chr 5:39,616,479...39,650,894
Ensembl chr 5:39,615,956...39,650,895
JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
IEA
ISS
(PMID:26268696)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26268696 GO_REF:0000024 GO_REF:0000107 NCBI chr14:42,537,352...42,559,580
Ensembl chr14:42,535,701...42,560,174
JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:15234121) RGD PMID:15234121 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Ficd FIC domain protein adenylyltransferase involved_in ISO
ISS
(PMID:25601083)
GO_REF:0000024
RGD
UniProt
PMID:25601083 GO_REF:0000024 NCBI chr12:48,658,283...48,663,175
Ensembl chr12:48,658,283...48,663,143
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    cellular process 18463
      signal transduction 6949
        endoplasmic reticulum unfolded protein response 75
          IRE1-mediated unfolded protein response 15
            negative regulation of IRE1-mediated unfolded protein response 6
            positive regulation of IRE1-mediated unfolded protein response 2
            regulation of IRE1-mediated unfolded protein response + 10
Path 2
Term Annotations click to browse term
  biological_process 19610
    response to stimulus 10427
      cellular response to stimulus 8795
        cellular response to chemical stimulus 3523
          cellular response to organic substance 2866
            cellular response to topologically incorrect protein 125
              cellular response to unfolded protein 103
                endoplasmic reticulum unfolded protein response 75
                  IRE1-mediated unfolded protein response 15
                    negative regulation of IRE1-mediated unfolded protein response 6
                    positive regulation of IRE1-mediated unfolded protein response 2
                    regulation of IRE1-mediated unfolded protein response + 10
paths to the root