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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to hydrogen peroxide
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Accession:GO:0036481 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).
Synonyms:exact_synonym: hydrogen peroxide-induced intrinsic apoptotic signaling pathway;   intrinsic apoptotic signaling pathway in response to H2O2
 broad_synonym: hydrogen peroxide-induced apoptosis
 related_synonym: H2O2-induced intrinsic apoptotic signaling pathway


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intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP2K4 mitogen-activated protein kinase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G PDCD10 programmed cell death 10 involved_in IGI (PMID:22652780) UniProt PMID:22652780 NCBI chr 3:167,683,298...167,734,892
Ensembl chr 3:167,683,298...167,734,939 		JBrowse link
G STK25 serine/threonine kinase 25 involved_in IGI (PMID:22652780) UniProt PMID:22652780 NCBI chr 2:241,492,670...241,509,572
Ensembl chr 2:241,492,670...241,509,730 		JBrowse link
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IEA
IGI		 (PMID:14652021) Ensembl
ParkinsonsUK-UCL		 PMID:14652021 GO_REF:0000107 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IMP
IDA		 (PMID:23261939)
(PMID:21177249)		 ParkinsonsUK-UCL PMID:21177249 PMID:23261939 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR133A1 microRNA 133a-1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr18:21,825,698...21,825,785
Ensembl chr18:21,825,698...21,825,785 		JBrowse link
G MIR133A2 microRNA 133a-2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr20:62,564,912...62,565,013
Ensembl chr20:62,564,912...62,565,013 		JBrowse link
G MIR92A1 microRNA 92a-1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr13:91,351,314...91,351,391
Ensembl chr13:91,351,314...91,351,391 		JBrowse link
G MIR92A2 microRNA 92a-2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr  X:134,169,538...134,169,612
Ensembl chr  X:134,169,538...134,169,612 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA
IDA		 (PMID:24947010) Ensembl
ParkinsonsUK-UCL		 PMID:24947010 GO_REF:0000107 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IDA (PMID:17579517) ParkinsonsUK-UCL PMID:17579517 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IGI
IEA		 (PMID:24947010) ParkinsonsUK-UCL
Ensembl		 PMID:24947010 GO_REF:0000107 NCBI chr 5:181,236,897...181,243,906
Ensembl chr 5:181,236,897...181,248,096 		JBrowse link
G TRAP1 TNF receptor associated protein 1 involved_in ISS (PMID:17579517) ParkinsonsUK-UCL PMID:17579517 NCBI chr16:3,658,037...3,717,524
Ensembl chr16:3,651,639...3,717,553 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    cellular process 18300
      signal transduction 6573
        intracellular signal transduction 2991
          intrinsic apoptotic signaling pathway 365
            intrinsic apoptotic signaling pathway in response to oxidative stress 72
              intrinsic apoptotic signaling pathway in response to hydrogen peroxide 11
                negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 8
                neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 2
                positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 0
                regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 8
Path 2
Term Annotations click to browse term
  biological_process 19669
    response to stimulus 10176
      response to stress 4593
        cellular response to stress 2146
          cellular response to chemical stress 441
            cellular response to oxidative stress 345
              cellular response to reactive oxygen species 223
                programmed cell death in response to reactive oxygen species 29
                  hydrogen peroxide-mediated programmed cell death 27
                    intrinsic apoptotic signaling pathway in response to hydrogen peroxide 11
                      negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 8
                      neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 2
                      positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide 0
                      regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 8
paths to the root