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ONTOLOGY REPORT - ANNOTATIONS


Term:TRAIL-activated apoptotic signaling pathway
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Accession:GO:0036462 term browser browse the term
Definition:An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.
Synonyms:exact_synonym: TRAIL-activated extrinsic apoptotic signaling pathway;   TRAIL-induced apoptotic signaling pathway;   tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway


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TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:1624291
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
RGD:13792537
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:1624291
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 JBrowse link 1 216,808,642 216,829,361 RGD:13792537
G Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 JBrowse link 8 132,156,216 132,204,484 RGD:1624291
negative regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
RGD:1600115
positive regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:1624291
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    signaling 7536
      signal transduction 6929
        apoptotic signaling pathway 629
          extrinsic apoptotic signaling pathway 235
            extrinsic apoptotic signaling pathway via death domain receptors 80
              TRAIL-activated apoptotic signaling pathway 9
                TRAIL death-inducing signaling complex assembly 0
                negative regulation of TRAIL-activated apoptotic signaling pathway 1
                positive regulation of TRAIL-activated apoptotic signaling pathway 3
                regulation of TRAIL-activated apoptotic signaling pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 19576
    cellular process 18361
      cell death 2129
        programmed cell death 1950
          apoptotic process 1903
            apoptotic signaling pathway 629
              extrinsic apoptotic signaling pathway 235
                extrinsic apoptotic signaling pathway via death domain receptors 80
                  TRAIL-activated apoptotic signaling pathway 9
                    TRAIL death-inducing signaling complex assembly 0
                    negative regulation of TRAIL-activated apoptotic signaling pathway 1
                    positive regulation of TRAIL-activated apoptotic signaling pathway 3
                    regulation of TRAIL-activated apoptotic signaling pathway + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.