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ONTOLOGY REPORT - ANNOTATIONS


Term:TCR signalosome
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Accession:GO:0036398 term browser browse the term
Definition:A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.
Synonyms:exact_synonym: LAT signalosome;   linker for activation of T cells signalosome


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TCR signalosome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lcp2 lymphocyte cytosolic protein 2 ISO (PMID:20551903) RGD PMID:20551903 NCBI chr10:18,996,523...19,043,289
Ensembl chr10:18,996,523...19,043,286
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G Stk11 serine/threonine kinase 11 ISO (MGI:MGI:5003385|PMID:21487392) RGD PMID:21487392 MGI:MGI:5003385 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link

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  cellular_component 20609
    protein-containing complex 6092
      TCR signalosome 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.