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ONTOLOGY REPORT - ANNOTATIONS

Term:TCR signalosome
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Accession:GO:0036398 term browser browse the term
Definition:A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.
Synonyms:exact_synonym: LAT signalosome;   linker for activation of T cells signalosome


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TCR signalosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lat linker for activation of T cells is_active_in ISO (PMID:33080222) RGD PMID:33080222 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578 		JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 part_of ISO (PMID:20551903) RGD PMID:20551903 NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559 		JBrowse link
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Path 1
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  cellular_component 20811
    protein-containing complex 6431
      TCR signalosome 2
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