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ONTOLOGY REPORT - ANNOTATIONS


Term:RNA N6-methyladenosine methyltransferase complex
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Accession:GO:0036396 term browser browse the term
Definition:A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
Synonyms:exact_synonym: Mum2, Ime4, and Slz1 complex;   WMM complex
 related_synonym: METTL3-METTL14-WTAP methyltransferase complex;   MIS complex;   m(6)A writer complex;   m6A methyltransferase complex



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RNA N6-methyladenosine methyltransferase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbll1 Cbl proto-oncogene like 1 part_of
located_in
ISO (PMID:29507755)
(MGI:6158697|PMID:29547716)
RGD PMID:29507755 PMID:29547716 MGI:6158697 NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444
JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase subunit part_of
located_in
IBA
ISO
PMID:21873635
(PMID:24316715), (PMID:24981863), (PMID:27627798), (PMID:29348140), (PMID:29507755)
(MGI:6158697|PMID:29547716)
(PMID:29507755)
RGD PMID:24316715 PMID:24981863 PMID:27627798 PMID:29348140 PMID:29507755 More... MGI:6158697, RGD:13792537 NCBI chr 2:211,530,598...211,546,858
Ensembl chr 2:211,530,602...211,546,821
JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit part_of
located_in
ISO
IBA
(PMID:24316715), (PMID:24407421), (PMID:24981863), (PMID:27602518), (PMID:27627798), (PMID:29348140), (PMID:29506078), (PMID:29507755)
(MGI:6158697|PMID:29547716)
(PMID:29507755)
PMID:21873635
RGD PMID:24316715 PMID:24407421 PMID:24981863 PMID:27602518 PMID:27627798 More... MGI:6158697, RGD:13792537 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041
JBrowse link
G Rbm15 RNA binding motif protein 15 part_of ISO (PMID:27602518) RGD PMID:27602518 NCBI chr 2:194,945,717...194,954,523
Ensembl chr 2:194,945,974...194,954,703
JBrowse link
G Rbm15b RNA binding motif protein 15B part_of ISO (PMID:27602518) RGD PMID:27602518 NCBI chr 8:107,543,542...107,548,195
Ensembl chr 8:107,525,898...107,551,696
JBrowse link
G Virma vir like m6A methyltransferase associated colocalizes_with
part_of
located_in
ISO
IBA
(PMID:24981863)
(PMID:29507755)
(MGI:6158697|PMID:29547716)
PMID:21873635
RGD PMID:24981863 PMID:29507755 PMID:29547716 PMID:21873635 MGI:6158697, RGD:13792537 NCBI chr 5:24,961,208...25,024,660
Ensembl chr 5:24,960,778...25,023,341
JBrowse link
G Wtap WT1 associated protein part_of
located_in
ISO (PMID:24316715), (PMID:24407421), (PMID:24981863), (PMID:29348140), (PMID:29506078), (PMID:29507755)
(MGI:6158697|PMID:29547716)
(PMID:29507755)
RGD PMID:24316715 PMID:24407421 PMID:24981863 PMID:29348140 PMID:29506078 More... MGI:6158697 NCBI chr 1:47,665,965...47,691,067
Ensembl chr 1:47,665,965...47,691,065
JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 part_of
located_in
ISO (PMID:29507755)
(MGI:6158697|PMID:29547716)
RGD PMID:29507755 PMID:29547716 MGI:6158697 NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20630
    cellular anatomical entity 20384
      intracellular anatomical structure 14853
        methyltransferase complex 104
          RNA N6-methyladenosine methyltransferase complex 8
Path 2
Term Annotations click to browse term
  cellular_component 20630
    protein-containing complex 6398
      catalytic complex 1809
        transferase complex 886
          methyltransferase complex 104
            RNA N6-methyladenosine methyltransferase complex 8
paths to the root