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Term:calcitriol biosynthetic process from calciol
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Accession:GO:0036378 term browser browse the term
Definition:Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms:exact_synonym: calcitriol biosynthesis from calciol;   vitamin D3 activation
 broad_synonym: 1alpha,25(OH)2D3 biosynthesis;   1alpha,25-dihydroxycholecalciferol biosynthesis;   1alpha,25-dihydroxyvitamin D3 biosynthesis

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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IBA
PMID:15465040, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO
(PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
RGD PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 PMID:17023519 PMID:22862690, PMID:21873635 MGI:3590419, RGD:13792537 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 involved_in ISO (PMID:15465040), (PMID:18511070) RGD PMID:15465040 PMID:18511070 NCBI chr 1:184,060,521...184,106,604
Ensembl chr 1:184,093,920...184,106,200
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link

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  biological_process 19491
    cellular process 18343
      cellular metabolic process 10755
        cellular biosynthetic process 5972
          cellular alcohol biosynthetic process 4
            calcitriol biosynthetic process from calciol 4
Path 2
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  biological_process 19491
    metabolic process 11797
      organic substance metabolic process 11337
        organic hydroxy compound metabolic process 550
          organic hydroxy compound biosynthetic process 239
            alcohol biosynthetic process 147
              polyol biosynthetic process 67
                calcitriol biosynthetic process from calciol 4
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