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ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol biosynthetic process from calciol
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Accession:GO:0036378 term browser browse the term
Definition:Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms:exact_synonym: calcitriol biosynthesis from calciol;   vitamin D3 activation
 broad_synonym: 1alpha,25(OH)2D3 biosynthesis;   1alpha,25-dihydroxycholecalciferol biosynthesis;   1alpha,25-dihydroxyvitamin D3 biosynthesis



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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr15:120,809,886...120,852,196
Ensembl chr15:120,809,959...120,852,193
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,050,114...23,058,470
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 involved_in IEA GOC
GOC
GO_REF:0000108 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,643
JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 2:44,375,432...44,394,122
Ensembl chr 2:44,375,520...44,396,367
JBrowse link
G METTL1 methyltransferase 1, tRNA methylguanosine involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:23,059,001...23,063,025
Ensembl chr 5:23,053,150...23,062,991
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17269
    cellular process 16298
      cellular metabolic process 9224
        cellular biosynthetic process 5314
          cellular alcohol biosynthetic process 5
            calcitriol biosynthetic process from calciol 5
Path 2
Term Annotations click to browse term
  biological_process 17269
    metabolic process 10885
      organic substance metabolic process 10445
        organic hydroxy compound metabolic process 533
          organic hydroxy compound biosynthetic process 238
            alcohol biosynthetic process 144
              polyol biosynthetic process 69
                calcitriol biosynthetic process from calciol 5
paths to the root