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ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol biosynthetic process from calciol
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Accession:GO:0036378 term browser browse the term
Definition:Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms:exact_synonym: calcitriol biosynthesis from calciol;   vitamin D3 activation
 broad_synonym: 1alpha,25(OH)2D3 biosynthesis;   1alpha,25-dihydroxycholecalciferol biosynthesis;   1alpha,25-dihydroxyvitamin D3 biosynthesis



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calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,042,235...106,076,840
Ensembl chr2B:224,637,238...224,671,474
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822
JBrowse link
G CYP2R1 cytochrome P450 family 2 subfamily R member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2677973|PMID:12867411) Ensembl
GOC
PMID:12867411 GO_REF:0000107 MGI:2677973 NCBI chr11:14,960,651...14,989,083
Ensembl chr11:14,656,939...14,671,584
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15338
    cellular process 14183
      cellular metabolic process 8338
        cellular biosynthetic process 4862
          cellular alcohol biosynthetic process 4
            calcitriol biosynthetic process from calciol 4
Path 2
Term Annotations click to browse term
  biological_process 15338
    metabolic process 10018
      organic substance metabolic process 9636
        organic hydroxy compound metabolic process 487
          organic hydroxy compound biosynthetic process 208
            alcohol biosynthetic process 123
              polyol biosynthetic process 64
                calcitriol biosynthetic process from calciol 4
paths to the root