Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol biosynthetic process from calciol
go back to main search page
Accession:GO:0036378 term browser browse the term
Definition:Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.
Synonyms:exact_synonym: calcitriol biosynthesis from calciol;   vitamin D3 activation
 broad_synonym: 1alpha,25(OH)2D3 biosynthesis;   1alpha,25-dihydroxycholecalciferol biosynthesis;   1alpha,25-dihydroxyvitamin D3 biosynthesis



show annotations for term's descendants           Sort by:
 
calcitriol biosynthetic process from calciol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IBA
ISO
IEA
PMID:21873635
(PMID:15465040)
GO_REF:0000107
RGD
Ensembl
PMID:15465040 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO
IBA
IEA
(PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
PMID:21873635
(MGI:3590419|PMID:15972816)
GO_REF:0000107
RGD
Ensembl
PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 PMID:17023519 More... GO_REF:0000107 MGI:3590419, RGD:13792537 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 involved_in
acts_upstream_of_or_within
ISO (PMID:15465040), (PMID:18511070)
(MGI:2677973|PMID:12867411)
RGD PMID:12867411 PMID:15465040 PMID:18511070 MGI:2677973 NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18872
    cellular process 17581
      cellular metabolic process 9824
        cellular biosynthetic process 5728
          cellular alcohol biosynthetic process 4
            calcitriol biosynthetic process from calciol 4
Path 2
Term Annotations click to browse term
  biological_process 18872
    metabolic process 11588
      organic substance metabolic process 11147
        organic hydroxy compound metabolic process 572
          organic hydroxy compound biosynthetic process 245
            alcohol biosynthetic process 151
              polyol biosynthetic process 70
                calcitriol biosynthetic process from calciol 4
paths to the root