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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta activation
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Accession:GO:0036363 term browser browse the term
Definition:The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.
Synonyms:exact_synonym: L-TGF-beta activation;   TGF-B activation;   TGF-beta activation;   TGFB activation;   TGFbeta activation;   latent TGF-beta activation



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transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 involved_in ISO (PMID:18672106) RGD PMID:18672106 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B involved_in ISO RGD DOI:10.1016/j.procbio.2011.10.027 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in ISO
ISS
(PMID:20599762)
GO_REF:0000024
RGD
UniProt
PMID:20599762 GO_REF:0000024 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
positive regulation of transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in ISO
IEA
(PMID:33082341)
GO_REF:0000107
RGD
Ensembl
PMID:33082341 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
IEA
ISS
(PMID:7737999)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:7737999 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V involved_in ISO (PMID:22278742) RGD PMID:22278742 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb6 integrin subunit beta 6 involved_in ISO
ISS
(PMID:22278742)
GO_REF:0000024
RGD
UniProt
PMID:22278742 GO_REF:0000024 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Itgb8 integrin subunit beta 8 involved_in ISO (MGI:5490445|PMID:22278742) RGD PMID:22278742 MGI:5490445 NCBI chr 6:140,124,997...140,208,254
Ensembl chr 6:140,127,203...140,208,476
JBrowse link
G Lrrc32 leucine rich repeat containing 32 involved_in ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) RGD PMID:19651619 PMID:19750484 PMID:22278742 NCBI chr 1:152,785,709...152,802,997
Ensembl chr 1:152,786,511...152,798,373
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 involved_in ISO
ISS
(PMID:2022183), (PMID:8617200)
GO_REF:0000024
RGD
UniProt
PMID:2022183 PMID:8617200 GO_REF:0000024 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 involved_in ISO (MGI:5920420|PMID:28912269) RGD PMID:28912269 MGI:5920420 NCBI chr 1:152,785,709...152,802,997
Ensembl chr 1:152,786,511...152,798,373
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species involved_in ISS
ISO
GO_REF:0000024
(MGI:6192878|PMID:29909984)
UniProt
RGD
PMID:29909984 GO_REF:0000024 MGI:6192878 NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    multicellular organismal process 8821
      transforming growth factor beta activation 11
        negative regulation of transforming growth factor beta activation + 2
        positive regulation of transforming growth factor beta activation + 2
        regulation of transforming growth factor beta activation + 9
        transforming growth factor beta1 activation + 2
        transforming growth factor beta2 activation + 0
        transforming growth factor beta3 activation + 1
Path 2
Term Annotations click to browse term
  biological_process 19390
    metabolic process 11736
      organic substance metabolic process 11278
        macromolecule metabolic process 9736
          gene expression 6238
            cytokine production 771
              transforming growth factor beta production 46
                transforming growth factor beta activation 11
                  negative regulation of transforming growth factor beta activation + 2
                  positive regulation of transforming growth factor beta activation + 2
                  regulation of transforming growth factor beta activation + 9
                  transforming growth factor beta1 activation + 2
                  transforming growth factor beta2 activation + 0
                  transforming growth factor beta3 activation + 1
paths to the root