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ONTOLOGY REPORT - ANNOTATIONS

Term:transforming growth factor beta activation
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Accession:GO:0036363 term browser browse the term
Definition:The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.
Synonyms:exact_synonym: L-TGF-beta activation;   TGF-B activation;   TGF-beta activation;   TGFB activation;   TGFbeta activation;   latent TGF-beta activation


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transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 involved_in ISO (PMID:18672106) RGD PMID:18672106 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975 		JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B involved_in ISO RGD DOI:10.1016/j.procbio.2011.10.027 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in ISO
IEA
ISS		 (PMID:20599762)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20599762 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
positive regulation of transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in ISO
IEA		 (PMID:33082341)
GO_REF:0000107		 RGD
Ensembl		 PMID:33082341 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 involved_in ISO (MGI:7444872|PMID:34615811) RGD PMID:34615811 MGI:7444872 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Agt angiotensinogen involved_in ISS
ISO		 GO_REF:0000024
(MGI:7444872|PMID:34615811)		 UniProt
RGD		 PMID:34615811 GO_REF:0000024 MGI:7444872 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V involved_in ISO (PMID:11970960), (PMID:22278742) RGD PMID:11970960 PMID:22278742 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb6 integrin subunit beta 6 involved_in ISO
ISS		 (PMID:22278742)
GO_REF:0000024		 RGD
UniProt		 PMID:22278742 GO_REF:0000024 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Itgb8 integrin subunit beta 8 involved_in ISO (MGI:5490445|PMID:22278742)
(PMID:11970960)		 RGD PMID:11970960 PMID:22278742 MGI:5490445 NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476 		JBrowse link
G Lrrc32 leucine rich repeat containing 32 involved_in ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) RGD PMID:19651619 PMID:19750484 PMID:22278742 NCBI chr 1:152,785,709...152,802,997
Ensembl chr 1:152,786,511...152,798,373 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 involved_in ISO
IEA
ISS		 (PMID:2022183), (PMID:8617200)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:2022183 PMID:8617200 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349 		JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 involved_in ISO (MGI:5920420|PMID:28912269) RGD PMID:28912269 MGI:5920420 NCBI chr 1:152,785,709...152,802,997
Ensembl chr 1:152,786,511...152,798,373 		JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species involved_in ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
PMID:21873635
(MGI:6192878|PMID:29909984)		 UniProt
Ensembl
RGD		 PMID:29909984 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:6192878, RGD:13792537 NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19527
    cellular process 18201
      cell communication 7664
        cell-cell signaling 1795
          transforming growth factor beta activation 12
            negative regulation of transforming growth factor beta activation + 2
            positive regulation of transforming growth factor beta activation + 3
            regulation of transforming growth factor beta activation + 10
            transforming growth factor beta1 activation + 3
            transforming growth factor beta2 activation + 0
            transforming growth factor beta3 activation + 1
Path 2
Term Annotations click to browse term
  biological_process 19527
    biological regulation 13192
      regulation of biological process 12837
        signaling 7532
          cell-cell signaling 1795
            transforming growth factor beta activation 12
              negative regulation of transforming growth factor beta activation + 2
              positive regulation of transforming growth factor beta activation + 3
              regulation of transforming growth factor beta activation + 10
              transforming growth factor beta1 activation + 3
              transforming growth factor beta2 activation + 0
              transforming growth factor beta3 activation + 1
paths to the root