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ONTOLOGY REPORT - ANNOTATIONS


Term:transforming growth factor beta activation
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Accession:GO:0036363 term browser browse the term
Definition:The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.
Synonyms:exact_synonym: L-TGF-beta activation;   TGF-B activation;   TGF-beta activation;   TGFB activation;   TGFbeta activation;   latent TGF-beta activation


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transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ltbp3 latent transforming growth factor beta binding protein 3 ISO (PMID:18672106) RGD PMID:18672106 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096
JBrowse link
negative regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B ISO RGD DOI:10.1016/j.procbio.2011.10.027 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 ISO
ISS
(PMID:20599762)
GO_REF:0000024
RGD
UniProt
PMID:20599762 GO_REF:0000024 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
negative regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:11583628) RGD PMID:11583628 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
positive regulation of transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin (paired basic amino acid cleaving enzyme) ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:7737999)
UniProt
Ensembl
RGD
PMID:7737999 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
regulation of transforming growth factor beta activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgav integrin subunit alpha V ISO (PMID:22278742) RGD PMID:22278742 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb6 integrin subunit beta 6 ISS
ISO
GO_REF:0000024
(PMID:22278742)
UniProt
RGD
PMID:22278742 GO_REF:0000024 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Itgb8 integrin subunit beta 8 ISO (MGI:5490445|PMID:22278742) RGD PMID:22278742 MGI:5490445 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Lrrc32 leucine rich repeat containing 32 ISO (PMID:19651619), (PMID:19750484), (PMID:22278742) RGD PMID:19651619, PMID:19750484, PMID:22278742 NCBI chr 1:163,443,972...163,457,426
Ensembl chr 1:163,445,527...163,457,424
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 ISS
ISO
IEA
GO_REF:0000024
(PMID:2022183), (PMID:8617200)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:2022183, PMID:8617200 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451
JBrowse link
regulation of transforming growth factor beta3 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 ISO (MGI:5920420|PMID:28912269) RGD PMID:28912269 MGI:5920420 NCBI chr 1:163,443,972...163,457,426
Ensembl chr 1:163,445,527...163,457,424
JBrowse link
transforming growth factor beta1 activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrros negative regulator of reactive oxygen species ISS
ISO
GO_REF:0000024
(MGI:6192878|PMID:29909984)
UniProt
RGD
PMID:29909984 GO_REF:0000024, MGI:6192878 NCBI chr11:71,872,728...71,889,897
Ensembl chr11:71,872,830...71,889,887
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    multicellular organismal process 9045
      transforming growth factor beta activation 11
        negative regulation of transforming growth factor beta activation + 3
        positive regulation of transforming growth factor beta activation + 1
        regulation of transforming growth factor beta activation + 9
        transforming growth factor beta1 activation + 3
        transforming growth factor beta2 activation + 0
        transforming growth factor beta3 activation + 1
Path 2
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      organic substance metabolic process 11552
        macromolecule metabolic process 9966
          gene expression 6295
            cytokine production 764
              transforming growth factor beta production 44
                transforming growth factor beta activation 11
                  negative regulation of transforming growth factor beta activation + 3
                  positive regulation of transforming growth factor beta activation + 1
                  regulation of transforming growth factor beta activation + 9
                  transforming growth factor beta1 activation + 3
                  transforming growth factor beta2 activation + 0
                  transforming growth factor beta3 activation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.