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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:Fas signaling pathway
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Accession:GO:0036337 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.
Synonyms:exact_synonym: Apo-1 signaling pathway;   CD95 signaling pathway;   Fas receptor signaling pathway;   FasR signaling pathway
 narrow_synonym: FAS ligand-Fas signaling pathway;   Fas-FasL signaling pathway
 related_synonym: FasL signaling pathway


show annotations for term's descendants           Sort by:
Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8AP2 caspase 8 associated protein 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:49,040,069...49,077,418
Ensembl chr12:49,039,411...49,077,688 		JBrowse link
G FAF1 Fas associated factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:10,232,520...10,691,106
Ensembl chr15:10,232,614...10,690,741 		JBrowse link
G FAS Fas cell surface death receptor involved_in ISO (PMID:11096076)
(PMID:12221075) 		CAFA
BHF-UCL		 PMID:11096076 PMID:12221075 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
negative regulation of Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD5 SMAD family member 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:24,027,603...24,082,673
Ensembl chr11:24,028,126...24,078,169 		JBrowse link
G TMBIM1 transmembrane BAX inhibitor motif containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:24,952,145...24,983,477
Ensembl chr37:24,952,902...24,958,137 		JBrowse link
positive regulation of Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR23A microRNA mir-23a acts_upstream_of ISO (PMID:26400397) BHF-UCL PMID:26400397 NCBI chr20:48,620,335...48,620,386
Ensembl chr20:48,620,323...48,620,397 		JBrowse link
G MIR27A microRNA mir-27a acts_upstream_of ISO (PMID:26400397) BHF-UCL PMID:26400397 NCBI chr20:48,620,556...48,620,615
Ensembl chr20:48,620,556...48,620,615 		JBrowse link
regulation of Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SP100 SP100 nuclear antigen involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:42,538,428...42,635,825
Ensembl chr25:42,538,571...42,635,649 		JBrowse link
G ZDHHC7 zinc finger DHHC-type palmitoyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:67,554,310...67,580,042
Ensembl chr 5:67,566,563...67,578,556 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22130
    cellular process 21661
      signal transduction 6408
        cell surface receptor signaling pathway 2830
          Fas signaling pathway 9
            negative regulation of Fas signaling pathway 2
            positive regulation of Fas signaling pathway 2
            regulation of Fas signaling pathway + 6
Path 2
Term Annotations click to browse term
  biological_process 22130
    biological regulation 12562
      regulation of biological process 12180
        signaling 6958
          signal transduction 6408
            cell surface receptor signaling pathway 2830
              Fas signaling pathway 9
                negative regulation of Fas signaling pathway 2
                positive regulation of Fas signaling pathway 2
                regulation of Fas signaling pathway + 6
paths to the root