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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:Fas signaling pathway
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Accession:GO:0036337 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.
Synonyms:exact_synonym: Apo-1 signaling pathway;   CD95 signaling pathway;   Fas receptor signaling pathway;   FasR signaling pathway
 narrow_synonym: FAS ligand-Fas signaling pathway;   Fas-FasL signaling pathway
 related_synonym: FasL signaling pathway


show annotations for term's descendants           Sort by:
Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8ap2 caspase 8 associated protein 2 involved_in ISO
IBA		 (PMID:17245429)
GO_REF:0000033		 RGD
GO_Central		 PMID:17245429 GO_REF:0000033 NCBI chr 5:51,809,366...51,848,633
Ensembl chr 5:47,014,667...47,052,275 		JBrowse link
G Faf1 Fas associated factor 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:15688372)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:15688372 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:129,654,677...130,018,604
Ensembl chr 5:124,426,062...124,789,977 		JBrowse link
G Fas Fas cell surface death receptor involved_in ISO (PMID:11096076), (PMID:12221075) RGD PMID:11096076 PMID:12221075 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
negative regulation of Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad5 SMAD family member 5 acts_upstream_of_or_within ISO
IEA		 (PMID:26400397)
GO_REF:0000107		 RGD
Ensembl		 PMID:26400397 GO_REF:0000107 NCBI chr17:7,867,640...7,896,983
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Tmbim1 transmembrane BAX inhibitor motif containing 1 involved_in ISO
IEA
ISS		 (PMID:21107705)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:21107705 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:83,320,972...83,338,469
Ensembl chr 9:75,871,835...75,889,069 		JBrowse link
positive regulation of Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir23a microRNA 23a acts_upstream_of ISO UniProtKB:Q99717 (PMID:26400397) RGD PMID:26400397 NCBI chr19:40,859,769...40,859,843
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mir27a microRNA 27a acts_upstream_of ISO UniProtKB:Q99717 (PMID:26400397) RGD PMID:26400397 NCBI chr19:40,859,603...40,859,689
Ensembl chr19:23,954,831...23,954,917 		JBrowse link
regulation of Fas signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sp100 SP100 nuclear antigen involved_in ISO (PMID:17245429) RGD PMID:17245429 NCBI chr 9:93,758,975...93,825,068
Ensembl chr 9:86,311,032...86,377,034 		JBrowse link
G Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 involved_in ISO
IEA
ISS		 (PMID:25301068)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:25301068 GO_REF:0000024 GO_REF:0000107 NCBI chr19:65,048,140...65,065,286
Ensembl chr19:48,139,527...48,156,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      signal transduction 7301
        cell surface receptor signaling pathway 2907
          Fas signaling pathway 9
            negative regulation of Fas signaling pathway 2
            positive regulation of Fas signaling pathway 2
            regulation of Fas signaling pathway + 6
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            cell surface receptor signaling pathway 2907
              Fas signaling pathway 9
                negative regulation of Fas signaling pathway 2
                positive regulation of Fas signaling pathway 2
                regulation of Fas signaling pathway + 6
paths to the root