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ONTOLOGY REPORT - ANNOTATIONS

Term:tyrosyl-RNA phosphodiesterase activity
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Accession:GO:0036317 term browser browse the term
Definition:Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.
Synonyms:exact_synonym: VPg unlinkase activity;   Y-pUpN PDE activity;   unlinkase activity;   uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity


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tyrosyl-RNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 enables ISO
IEA		 (PMID:22908287)
GO_REF:0000107		 RGD
Ensembl		 PMID:22908287 GO_REF:0000107 NCBI chr17:40,228,943...40,240,337
Ensembl chr17:40,228,947...40,240,313 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20732
    catalytic activity 6110
      catalytic activity, acting on a nucleic acid 634
        catalytic activity, acting on RNA 398
          tyrosyl-RNA phosphodiesterase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20732
    catalytic activity 6110
      hydrolase activity 2596
        hydrolase activity, acting on ester bonds 811
          phosphoric ester hydrolase activity 370
            phosphoric diester hydrolase activity 88
              tyrosyl-RNA phosphodiesterase activity 1
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