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ONTOLOGY REPORT - ANNOTATIONS

Term:interstrand cross-link repair
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Accession:GO:0036297 term browser browse the term
Definition:Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
Synonyms:exact_synonym: ICL repair


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interstrand cross-link repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenps centromere protein S involved_in ISO (PMID:20347429) RGD PMID:20347429 NCBI chr 5:159,563,917...159,573,534 JBrowse link
G Cenpx centromere protein X involved_in ISO (PMID:20347429) RGD PMID:20347429 NCBI chr10:105,991,469...105,994,411 JBrowse link
G Dclre1a DNA cross-link repair 1A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:255,569,911...255,589,815
Ensembl chr 1:255,569,919...255,589,678 		JBrowse link
G Dclre1b DNA cross-link repair 1B involved_in IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(PMID:20479256)		 Ensembl
RGD		 PMID:20479256 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 2:191,309,909...191,318,399
Ensembl chr 2:191,309,913...191,318,423 		JBrowse link
G Dclre1c DNA cross-link repair 1C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO (MGI:5506835|PMID:23637614) RGD PMID:23637614 MGI:5506835 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc6l2 ERCC excision repair 6 like 2 involved_in ISO (PMID:24507776) RGD PMID:24507776 NCBI chr17:1,076,486...1,311,281
Ensembl chr17:1,216,428...1,310,275 		JBrowse link
G Exo5 exonuclease 5 involved_in ISO
IBA		 (PMID:23095756)
PMID:21873635		 RGD PMID:23095756 PMID:21873635 RGD:13792537 NCBI chr 5:134,494,440...134,497,757
Ensembl chr 5:134,493,829...134,497,772 		JBrowse link
G Faap100 FA core complex associated protein 100 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:105,641,677...105,653,809
Ensembl chr10:105,639,414...105,653,494 		JBrowse link
G Faap20 FA core complex associated protein 20 involved_in ISO
ISS		 (PMID:22266823), (PMID:22396592), (PMID:22705371)
GO_REF:0000024		 RGD
UniProt		 PMID:22266823 PMID:22396592 PMID:22705371 GO_REF:0000024 NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333 		JBrowse link
G Faap24 FA core complex associated protein 24 involved_in ISO (PMID:20347429) RGD PMID:20347429 NCBI chr 1:88,051,523...88,057,997
Ensembl chr 1:88,051,911...88,057,989 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 involved_in ISO
IBA		 (PMID:25430771)
PMID:21873635		 RGD PMID:25430771 PMID:21873635 RGD:13792537 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
G Fanca FA complementation group A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:51,304,021...51,362,586
Ensembl chr19:51,304,021...51,362,527 		JBrowse link
G Fancb FA complementation group B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192 		JBrowse link
G Fancc FA complementation group C involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376 		JBrowse link
G Fancd2 FA complementation group D2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Fance FA complementation group E involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631 		JBrowse link
G Fancf FA complementation group F involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:101,449,120...101,452,361
Ensembl chr 1:101,450,389...101,451,923 		JBrowse link
G Fancg FA complementation group G involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Fancl FA complementation group L involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255 		JBrowse link
G Fancm FA complementation group M involved_in ISO
IBA		 (PMID:20347429)
PMID:21873635		 RGD PMID:20347429 PMID:21873635 RGD:13792537 NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028 		JBrowse link
G Hrob homologous recombination factor with OB-fold involved_in ISO
IEA
ISS		 (PMID:31467087)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:31467087 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,206,017...87,222,483
Ensembl chr10:87,206,049...87,222,483 		JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 involved_in ISO
IBA		 (PMID:26323318)
PMID:21873635		 RGD PMID:26323318 PMID:21873635 RGD:13792537 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229 		JBrowse link
G Poln DNA polymerase nu involved_in ISO (PMID:19908865), (PMID:19995904) RGD PMID:19908865 PMID:19995904 NCBI chr14:76,579,983...76,752,460
Ensembl chr14:76,580,546...76,752,463 		JBrowse link
G Rad51 RAD51 recombinase involved_in ISO (PMID:26253028) RGD PMID:26253028 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 involved_in IBA
ISO		 PMID:21873635
(PMID:26323318)		 RGD PMID:26323318 PMID:21873635 RGD:13792537 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rad51d RAD51 paralog D acts_upstream_of_or_within ISO MGI:2386281 (MGI:3574680|PMID:15781618) RGD PMID:15781618 MGI:3574680 NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:28575657), (PMID:28575658) RGD PMID:28575657 PMID:28575658 NCBI chr19:39,235,883...39,268,536
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:11,526,563...11,549,291
Ensembl chr10:11,528,424...11,549,295 		JBrowse link
G Vcp valosin-containing protein involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:26323318) RGD PMID:26323318 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
nucleotide-excision repair involved in interstrand cross-link repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO
IBA		 (PMID:32034146)
PMID:21873635		 RGD PMID:32034146 PMID:21873635 RGD:13792537 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Ercc4l1 excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:954,927...983,651
Ensembl chr10:954,977...983,174 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
recombinational interstrand cross-link repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor involved_in ISO (PMID:23401855) RGD PMID:23401855 NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008 		JBrowse link
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor involved_in ISO (PMID:23401855)
(MGI:5525985|PMID:23401855)		 RGD PMID:23401855 MGI:5525985 NCBI chr20:32,818,219...32,929,577
Ensembl chr20:32,844,951...32,929,600 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    metabolic process 11591
      cellular metabolic process 9831
        cellular macromolecule metabolic process 3481
          DNA metabolic process 999
            DNA repair 512
              interstrand cross-link repair 36
                non-recombinational interstrand cross-link repair 0
                nucleotide-excision repair involved in interstrand cross-link repair 3
                recombinational interstrand cross-link repair 2
Path 2
Term Annotations click to browse term
  biological_process 18877
    metabolic process 11591
      cellular metabolic process 9831
        cellular aromatic compound metabolic process 5651
          nucleobase-containing compound metabolic process 5422
            nucleic acid metabolic process 4890
              DNA metabolic process 999
                DNA repair 512
                  interstrand cross-link repair 36
                    non-recombinational interstrand cross-link repair 0
                    nucleotide-excision repair involved in interstrand cross-link repair 3
                    recombinational interstrand cross-link repair 2
paths to the root