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ONTOLOGY REPORT - ANNOTATIONS

Term:phenotypic switching
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Accession:GO:0036166 term browser browse the term
Definition:A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
Comment:Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
Synonyms:related_synonym: phenotypic dimorphism

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phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt2 euchromatic histone lysine methyltransferase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24584053) Ensembl
MGI		 PMID:24584053 GO_REF:0000107 NCBI chrNW_004936727:1,648,451...1,663,294
Ensembl chrNW_004936727:1,648,448...1,663,455 		JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:520,181...565,496
Ensembl chrNW_004936659:520,493...565,416 		JBrowse link
G Fgf9 fibroblast growth factor 9 involved_in ISO PMID:28259995 BHF-UCL PMID:28259995 RGD:13601993 NCBI chrNW_004936720:282,291...316,629
Ensembl chrNW_004936720:279,521...316,674 		JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfb platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573 		JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sod2 superoxide dismutase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
regulation of phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myocd myocardin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:5,256,615...5,356,563
Ensembl chrNW_004936595:5,256,785...5,351,723 		JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 involved_in ISO PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chrNW_004936659:324,996...385,646
Ensembl chrNW_004936659:325,436...372,225 		JBrowse link
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