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ONTOLOGY REPORT - ANNOTATIONS


Term:phenotypic switching
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Accession:GO:0036166 term browser browse the term
Definition:A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
Comment:Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
Synonyms:related_synonym: phenotypic dimorphism



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phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO MGI:4418499 (MGI:5577209|PMID:24584053) RGD PMID:24584053 MGI:5577209 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:23441172) RGD PMID:23441172 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 involved_in ISO
IEA
(PMID:27021683)
GO_REF:0000107
RGD
Ensembl
PMID:27021683 GO_REF:0000107 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Fgf9 fibroblast growth factor 9 involved_in IMP PMID:28259995 BHF-UCL PMID:28259995 RGD:13601993 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir214 microRNA 214 involved_in ISO (PMID:27144530) RGD PMID:27144530 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:19088079) RGD PMID:19088079 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
IEA
(PMID:19088079)
GO_REF:0000107
RGD
Ensembl
PMID:19088079 GO_REF:0000107 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir140 microRNA 140 involved_in ISO (PMID:27021683) RGD PMID:27021683 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
JBrowse link
G Mir145 microRNA 145 IMP RGD PMID:19542014 RGD:13210556 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Sod2 superoxide dismutase 2 involved_in ISO (PMID:27021683) RGD PMID:27021683 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
regulation of phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myocd myocardin involved_in IEA
ISO
GO_REF:0000107
RNAcentral:URS0000527F89_10090 (MGI:4354665|PMID:19578358)
Ensembl
RGD
PMID:19578358 GO_REF:0000107 MGI:4354665 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 involved_in IMP PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chr 8:19,204,472...19,282,154
Ensembl chr 8:19,204,475...19,282,117
JBrowse link
reversible differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir1 microRNA 1 involved_in ISO (PMID:21051663) RGD PMID:21051663 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir1b microRNA 1b involved_in ISO (PMID:21051663) RGD PMID:21051663 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201
JBrowse link

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