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ONTOLOGY REPORT - ANNOTATIONS

Term:phenotypic switching
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Accession:GO:0036166 term browser browse the term
Definition:A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
Comment:Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'.
Synonyms:related_synonym: phenotypic dimorphism


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phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO MGI:4418499 (PMID:24584053) RGD PMID:24584053 NCBI chr20:3,924,263...3,941,238
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:23441172) RGD PMID:23441172 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
negative regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir182 microRNA 182 involved_in ISO (PMID:28259995) RGD PMID:28259995 NCBI chr 4:59,752,246...59,752,307
Ensembl chr 4:58,784,818...58,784,879 		JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 involved_in ISO
IEA		 (PMID:27021683)
GO_REF:0000107		 RGD
Ensembl		 PMID:27021683 GO_REF:0000107 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Fgf9 fibroblast growth factor 9 involved_in IMP PMID:28259995 BHF-UCL PMID:28259995 RGD:13601993 NCBI chr15:36,325,552...36,369,995
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir214 microRNA 214 involved_in ISO (PMID:27144530) RGD PMID:27144530 NCBI chr13:77,121,645...77,121,752
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:19088079) RGD PMID:19088079 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO
IEA		 (PMID:19088079)
GO_REF:0000107		 RGD
Ensembl		 PMID:19088079 GO_REF:0000107 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir140 microRNA 140 involved_in ISO (PMID:27021683) RGD PMID:27021683 NCBI chr19:52,375,293...52,375,391
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir145 microRNA 145 IMP RGD PMID:19542014 RGD:13210556 NCBI chr18:57,369,983...57,370,070
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Sod2 superoxide dismutase 2 involved_in ISO
IEA		 (PMID:27021683)
GO_REF:0000107		 RGD
Ensembl		 PMID:27021683 GO_REF:0000107 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
regulation of phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myocd myocardin involved_in ISO RNAcentral:URS0000527F89_10090 (PMID:19578358) RGD PMID:19578358 NCBI chr10:50,332,356...50,426,819
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 involved_in IMP PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chr 8:19,204,472...19,282,154
Ensembl chr 8:19,204,475...19,282,117 		JBrowse link
reversible differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir1 microRNA 1 involved_in ISO (PMID:21051663) RGD PMID:21051663 NCBI chr18:2,160,327...2,160,413 JBrowse link
G Mir1a-1 microRNA 1a-1 involved_in ISO (PMID:21051663) RGD PMID:21051663 NCBI chr 3:187,864,685...187,864,769
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
Term paths to the root