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ONTOLOGY REPORT - ANNOTATIONS

Term:MKS complex
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Accession:GO:0036038 term browser browse the term
Definition:A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
Comment:Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
Synonyms:exact_synonym: MKS module
 narrow_synonym: B9 complex;   tectonic complex;   tectonic-like complex
 broad_synonym: TCTN-B9D complex


show annotations for term's descendants           Sort by:
MKS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 part_of ISS
ISO		 GO_REF:0000024
(PMID:22179047)		 UniProt
RGD		 PMID:22179047 GO_REF:0000024 NCBI chr 1:15,762,485...15,891,213
Ensembl chr 1:15,762,462...15,891,041 		JBrowse link
G B9d1 B9 domain containing 1 part_of ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:5288576|PMID:21725307), (PMID:22179047)		 UniProt
GO_Central
RGD		 PMID:21725307 PMID:22179047 GO_REF:0000024 GO_REF:0000033 MGI:5288576 NCBI chr10:46,186,222...46,196,309
Ensembl chr10:46,186,691...46,196,008 		JBrowse link
G B9d2 B9 domain containing 2 part_of ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:22179047)		 UniProt
GO_Central
RGD		 PMID:22179047 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:81,189,395...81,195,383
Ensembl chr 1:81,189,405...81,195,356 		JBrowse link
G Cc2d2a coiled-coil and C2 domain containing 2A part_of ISO (MGI:5288576|PMID:21725307), (PMID:22179047) RGD PMID:21725307 PMID:22179047 MGI:5288576 NCBI chr14:67,349,004...67,435,883
Ensembl chr14:67,351,353...67,435,949 		JBrowse link
G Cep290 centrosomal protein 290 part_of ISO (MGI:5288576|PMID:21725307) RGD PMID:21725307 MGI:5288576 NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392 		JBrowse link
G Kctd10 potassium channel tetramerization domain containing 10 part_of ISO (PMID:22179047) RGD PMID:22179047 NCBI chr12:42,230,159...42,248,792
Ensembl chr12:42,230,269...42,248,783 		JBrowse link
G Mks1 MKS transition zone complex subunit 1 part_of ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(MGI:5288576|PMID:21725307), (PMID:22179047)		 UniProt
Ensembl
GO_Central
RGD		 PMID:21725307 PMID:22179047 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5288576 NCBI chr10:72,655,921...72,667,007
Ensembl chr10:72,655,921...72,666,655 		JBrowse link
G Tctn1 tectonic family member 1 part_of IBA
ISO		 GO_REF:0000033
(MGI:5288576|PMID:21725307), (PMID:22179047)		 GO_Central
RGD		 PMID:21725307 PMID:22179047 GO_REF:0000033 MGI:5288576 NCBI chr12:34,309,795...34,347,190
Ensembl chr12:34,309,897...34,342,267 		JBrowse link
G Tctn2 tectonic family member 2 part_of ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:5288576|PMID:21725307), (PMID:22179047)		 UniProt
GO_Central
RGD		 PMID:21725307 PMID:22179047 GO_REF:0000024 GO_REF:0000033 MGI:5288576 NCBI chr12:31,982,440...32,007,242
Ensembl chr12:31,822,733...32,007,069 		JBrowse link
G Tmem107 transmembrane protein 107 part_of ISO
ISS
IEA
IBA		 (PMID:26595381)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:26595381 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:53,772,153...53,774,685
Ensembl chr10:53,771,784...53,774,676 		JBrowse link
G Tmem17 transmembrane protein 17 part_of ISS
ISO		 GO_REF:0000024
(PMID:22179047)		 UniProt
RGD		 PMID:22179047 GO_REF:0000024 NCBI chr14:96,483,648...96,524,238
Ensembl chr14:96,518,793...96,524,233 		JBrowse link
G Tmem216 transmembrane protein 216 part_of ISS
ISO		 GO_REF:0000024
(MGI:5288576|PMID:21725307)		 UniProt
RGD		 PMID:21725307 GO_REF:0000024 MGI:5288576 NCBI chr 1:207,196,454...207,201,704
Ensembl chr 1:207,196,454...207,201,754 		JBrowse link
G Tmem231 transmembrane protein 231 part_of ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22179047)		 UniProt
Ensembl
RGD		 PMID:22179047 GO_REF:0000024 GO_REF:0000107 NCBI chr19:39,883,077...39,904,296
Ensembl chr19:39,883,077...39,904,269 		JBrowse link
G Tmem67 transmembrane protein 67 part_of IEA
ISS
ISO		 GO_REF:0000002
GO_REF:0000024
(MGI:5288576|PMID:21725307)		 InterPro
UniProt
RGD		 PMID:21725307 GO_REF:0000002 GO_REF:0000024 MGI:5288576 NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20813
    protein-containing complex 6433
      MKS complex 14
Path 2
Term Annotations click to browse term
  cellular_component 20813
    cellular anatomical entity 20576
      organelle 14001
        membrane-bounded organelle 12601
          cilium 802
            ciliary transition zone 79
              MKS complex 14
paths to the root