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ONTOLOGY REPORT - ANNOTATIONS


Term:MKS complex
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Accession:GO:0036038 term browser browse the term
Definition:A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.
Comment:Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
Synonyms:exact_synonym: MKS module
 narrow_synonym: B9 complex;   tectonic complex;   tectonic-like complex
 broad_synonym: TCTN-B9D complex


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MKS complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 part_of ISS
ISO
GO_REF:0000024
(MGI:5300833|PMID:22179047)
UniProt
RGD
PMID:22179047 GO_REF:0000024 MGI:5300833 NCBI chr 1:16,478,127...16,601,769
Ensembl chr 1:16,478,127...16,601,769
JBrowse link
G B9d1 B9 domain containing 1 part_of IBA
ISO
ISS
PMID:21873635
(MGI:5288576|PMID:21725307), (MGI:5300833|PMID:22179047)
GO_REF:0000024
RGD
UniProt
PMID:21725307 PMID:22179047, PMID:21873635 GO_REF:0000024 MGI:5288576 MGI:5300833, RGD:13792537 NCBI chr10:47,784,294...47,794,399
Ensembl chr10:47,785,033...47,792,590
Ensembl chr10:47,785,033...47,792,590
JBrowse link
G B9d2 B9 domain containing 2 part_of ISS
ISO
IBA
GO_REF:0000024
(MGI:5300833|PMID:22179047)
PMID:21873635
UniProt
RGD
PMID:22179047, PMID:21873635 GO_REF:0000024 MGI:5300833, RGD:13792537 NCBI chr 1:82,473,254...82,479,704
Ensembl chr 1:82,473,737...82,479,900
JBrowse link
G Cc2d2a coiled-coil and C2 domain containing 2A part_of ISO (MGI:5288576|PMID:21725307), (MGI:5300833|PMID:22179047) RGD PMID:21725307 PMID:22179047 MGI:5288576 MGI:5300833 NCBI chr14:71,895,128...71,979,452
Ensembl chr14:71,895,246...71,973,419
JBrowse link
G Cep290 centrosomal protein 290 part_of ISO (MGI:5288576|PMID:21725307) RGD PMID:21725307 MGI:5288576 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Kctd10 potassium channel tetramerization domain containing 10 part_of ISO (MGI:5300833|PMID:22179047) RGD PMID:22179047 MGI:5300833 NCBI chr12:47,992,079...48,010,531
Ensembl chr12:47,992,091...48,010,583
JBrowse link
G Mks1 MKS transition zone complex subunit 1 part_of IBA
ISO
IEA
ISS
PMID:21873635
(MGI:5288576|PMID:21725307), (MGI:5300833|PMID:22179047)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:21725307 PMID:22179047, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5288576 MGI:5300833, RGD:13792537 NCBI chr10:75,149,814...75,160,481
Ensembl chr10:75,149,814...75,160,480
JBrowse link
G Tctn1 tectonic family member 1 part_of IBA
ISO
PMID:21873635
(MGI:5288576|PMID:21725307), (MGI:5300833|PMID:22179047)
RGD PMID:21725307 PMID:22179047, PMID:21873635 MGI:5288576 MGI:5300833, RGD:13792537 NCBI chr12:39,790,948...39,828,215
Ensembl chr12:39,790,965...39,824,064
JBrowse link
G Tctn2 tectonic family member 2 part_of IBA
ISO
ISS
PMID:21873635
(MGI:5288576|PMID:21725307), (MGI:5300833|PMID:22179047)
GO_REF:0000024
RGD
UniProt
PMID:21725307 PMID:22179047, PMID:21873635 GO_REF:0000024 MGI:5288576 MGI:5300833, RGD:13792537 NCBI chr12:37,400,896...37,427,256
Ensembl chr12:37,363,906...37,425,596
JBrowse link
G Tmem107 transmembrane protein 107 part_of ISO
ISS
IBA
(PMID:26595381)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:26595381, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:55,653,694...55,656,270
Ensembl chr10:55,653,946...55,656,270
JBrowse link
G Tmem17 transmembrane protein 17 part_of ISS
ISO
GO_REF:0000024
(MGI:5300833|PMID:22179047)
UniProt
RGD
PMID:22179047 GO_REF:0000024 MGI:5300833 NCBI chr14:107,268,235...107,308,546
Ensembl chr14:107,268,128...107,308,542
JBrowse link
G Tmem216 transmembrane protein 216 part_of ISS
ISO
GO_REF:0000024
(MGI:5288576|PMID:21725307)
UniProt
RGD
PMID:21725307 GO_REF:0000024 MGI:5288576 NCBI chr 1:226,601,201...226,606,417
Ensembl chr 1:226,601,201...226,606,344
JBrowse link
G Tmem231 transmembrane protein 231 part_of ISS
ISO
GO_REF:0000024
(MGI:5300833|PMID:22179047)
UniProt
RGD
PMID:22179047 GO_REF:0000024 MGI:5300833 NCBI chr19:44,137,444...44,158,624
Ensembl chr19:44,137,423...44,158,624
JBrowse link
G Tmem67 transmembrane protein 67 part_of IEA
ISO
ISS
GO_REF:0000002
(MGI:5288576|PMID:21725307)
GO_REF:0000024
InterPro
RGD
UniProt
PMID:21725307 GO_REF:0000002 GO_REF:0000024 MGI:5288576 NCBI chr 5:25,666,138...25,721,056
Ensembl chr 5:25,666,137...25,721,072
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20142
    protein-containing complex 6031
      MKS complex 14
Path 2
Term Annotations click to browse term
  cellular_component 20142
    cellular anatomical entity 19842
      organelle 13139
        membrane-bounded organelle 11689
          cilium 693
            ciliary transition zone 75
              MKS complex 14
paths to the root