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ONTOLOGY REPORT - ANNOTATIONS


Term:CD8-positive, alpha-beta T cell activation
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Accession:GO:0036037 term browser browse the term
Definition:The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.



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CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of ISO MGI:3053071|MGI:5609428 (MGI:5451119|PMID:23123061) RGD PMID:23123061 MGI:5451119 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Clec4a C-type lectin domain family 4, member A involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 involved_in ISO (PMID:20530286) RGD PMID:20530286 NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:25631937) RGD PMID:25631937 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:25631937) RGD PMID:25631937 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Wdfy4 WDFY family member 4 acts_upstream_of_or_within_positive_effect ISO (MGI:6257237|PMID:30409884) RGD PMID:30409884 MGI:6257237 NCBI chr16:8,221,853...8,450,494
Ensembl chr16:8,221,719...8,450,491
JBrowse link
CD8-positive, alpha-beta intraepithelial T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr18 G protein-coupled receptor 18 acts_upstream_of_or_within ISO MGI:5708707 (MGI:5629467|PMID:25348153) RGD PMID:25348153 MGI:5629467 NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470
JBrowse link
CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gimap1 GTPase, IMAP family member 1 acts_upstream_of_or_within ISO MGI:2449947|MGI:4459837 (MGI:4455099|PMID:20194894) RGD PMID:20194894 MGI:4455099 NCBI chr 4:77,687,581...77,691,468
Ensembl chr 4:77,682,171...77,691,866
JBrowse link
G Irf1 interferon regulatory factor 1 acts_upstream_of_or_within ISO MGI:1857205 (MGI:1934722|PMID:11359801) RGD PMID:11359801 MGI:1934722 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO MGI:2386448|MGI:5752247 (MGI:5621075|PMID:25470037) RGD PMID:25470037 MGI:5621075 NCBI chr  X:14,626,173...14,659,331
Ensembl chr  X:14,626,164...14,659,573
JBrowse link
G Pax1 paired box 1 acts_upstream_of_or_within ISO MGI:3603176 (MGI:3590033|PMID:16093716) RGD PMID:16093716 MGI:3590033 NCBI chr 3:134,789,291...134,801,636
Ensembl chr 3:134,789,182...134,801,636
JBrowse link
G Psmb11 proteasome subunit beta 11 acts_upstream_of_or_within ISO MGI:3716870 (MGI:3712579|PMID:17540904), (MGI:6392185|PMID:31915251) RGD PMID:17540904 PMID:31915251 MGI:3712579 MGI:6392185 NCBI chr15:28,081,148...28,087,326 JBrowse link
G Satb1 SATB homeobox 1 acts_upstream_of_or_within ISO MGI:2386676 (MGI:1354431|PMID:10716941), (MGI:3577552|PMID:15814699) RGD PMID:10716941 PMID:15814699 MGI:1354431 MGI:3577552 NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251
JBrowse link
G Tnfsf8 TNF superfamily member 8 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3054968 (MGI:3700858|PMID:16177108)
RGD PMID:16177108 PMID:21873635 MGI:3700858, RGD:13792537 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421
JBrowse link
CD8-positive, alpha-beta T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in IBA
ISO
PMID:21873635
(MGI:4399030|PMID:14605368)
(PMID:17566017)
RGD PMID:14605368 PMID:17566017 PMID:21873635 MGI:4399030, RGD:13792537 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:3829555|PMID:17277142) RGD PMID:17277142 MGI:3829555 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:2156165 (MGI:2156164|PMID:8170972) RGD PMID:8170972 MGI:2156164 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:2159528|PMID:11850626), (MGI:3045816|PMID:15078895) RGD PMID:11850626 PMID:15078895 MGI:2159528 MGI:3045816 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule involved_in ISO (PMID:28813410), (PMID:28813417) RGD PMID:28813410 PMID:28813417 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Hfe homeostatic iron regulator involved_in ISO UniProtKB:P04439 (PMID:24643698) RGD PMID:24643698 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6140589|PMID:24880459)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:24880459 GO_REF:0000024 GO_REF:0000107 MGI:6140589 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:5446998|PMID:22730529), (MGI:6140589|PMID:24880459) RGD PMID:22730529 PMID:24880459 MGI:5446998 MGI:6140589 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
negative regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:3053071|MGI:5609428 (MGI:5451119|PMID:23123061) RGD PMID:23123061 MGI:5451119 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:28676677) RGD PMID:28676677 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:28676677) RGD PMID:28676677 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbfb core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18420485) RGD PMID:18420485 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO
GO_REF:0000024
(MGI:3818191|PMID:19015308)
UniProt
RGD
PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,443...134,622,934
Ensembl chr 7:134,577,482...134,622,934
JBrowse link
G Runx1 RUNX family transcription factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3772948|PMID:18258917)
UniProt
RGD
PMID:18258917 GO_REF:0000024 MGI:3772948 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Runx3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) RGD PMID:18258917 MGI:3772948 NCBI chr 5:147,393,926...147,419,161
Ensembl chr 5:147,360,994...147,419,156
JBrowse link
positive regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd244 CD244 molecule involved_in ISO (MGI:5700312|PMID:11739483) RGD PMID:11739483 MGI:5700312 NCBI chr13:84,018,887...84,036,612
Ensembl chr13:84,020,095...84,036,100
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in IBA
ISO
PMID:21873635
(MGI:5562517|PMID:23871208)
RGD PMID:23871208 PMID:21873635 MGI:5562517, RGD:13792537 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 involved_in ISO (PMID:25631937) RGD PMID:25631937 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 involved_in ISO (PMID:25631937) RGD PMID:25631937 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in ISO (PMID:10887101) RGD PMID:10887101 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
regulation of CD8-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crtam cytotoxic and regulatory T cell molecule involved_in ISO (MGI:4359960|PMID:19752223) RGD PMID:19752223 MGI:4359960 NCBI chr 8:41,340,117...41,377,343
Ensembl chr 8:41,340,837...41,377,343
JBrowse link
regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B acts_upstream_of_or_within ISO MGI:3817628 (MGI:3817343|PMID:18776904) RGD PMID:18776904 MGI:3817343 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
regulation of CD8-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5317515|PMID:21909274)
UniProt
RGD
PMID:21909274 GO_REF:0000024 MGI:5317515 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5546548|PMID:23963642)
UniProt
RGD
PMID:23963642 GO_REF:0000024 MGI:5546548 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5546548|PMID:23963642)
UniProt
RGD
PMID:23963642 GO_REF:0000024 MGI:5546548 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    immune system process 2569
      leukocyte activation 1038
        lymphocyte activation 849
          T cell activation 567
            alpha-beta T cell activation 190
              CD8-positive, alpha-beta T cell activation 34
                CD8-positive, alpha-beta T cell differentiation + 19
                CD8-positive, alpha-beta T cell proliferation + 9
                negative regulation of CD8-positive, alpha-beta T cell activation + 5
                positive regulation of CD8-positive, alpha-beta T cell activation + 11
                regulation of CD8-positive, alpha-beta T cell activation + 20
Path 2
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      cell activation 1190
        leukocyte activation 1038
          lymphocyte activation 849
            T cell activation 567
              alpha-beta T cell activation 190
                CD8-positive, alpha-beta T cell activation 34
                  CD8-positive, alpha-beta T cell differentiation + 19
                  CD8-positive, alpha-beta T cell proliferation + 9
                  negative regulation of CD8-positive, alpha-beta T cell activation + 5
                  positive regulation of CD8-positive, alpha-beta T cell activation + 11
                  regulation of CD8-positive, alpha-beta T cell activation + 20
paths to the root