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ONTOLOGY REPORT - ANNOTATIONS


Term:tendon cell differentiation
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Accession:GO:0035990 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.
Synonyms:exact_synonym: muscle attachment cell differentiation
 related_synonym: tenocyte differentiation


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tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:4418577|PMID:20059955)
Ensembl
UniProt
RGD
PMID:20059955 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4418577 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Mkx mohawk homeobox ISO MGI:MGI:5287572 (MGI:MGI:5287220|PMID:20696843) RGD PMID:20696843 MGI:MGI:5287220 NCBI chr17:60,537,615...60,553,284
Ensembl chr17:60,537,935...60,549,750
JBrowse link
G Scx scleraxis bHLH transcription factor ISO (MGI:MGI:3715390|PMID:17567668), (MGI:MGI:4418577|PMID:20059955) RGD PMID:17567668, PMID:20059955 MGI:MGI:3715390, MGI:MGI:4418577 NCBI chr 7:117,519,075...117,521,093
Ensembl chr 7:117,519,075...117,521,093
JBrowse link
G Tnmd tenomodulin IEP PMID:21412429 UniProt PMID:21412429 RGD:8553701 NCBI chr  X:104,684,676...104,700,173
Ensembl chr  X:104,684,676...104,700,173
JBrowse link
positive regulation of tendon cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdf7 growth differentiation factor 7 ISO (MGI:MGI:5294519|PMID:21412429) RGD PMID:21412429 MGI:MGI:5294519 NCBI chr 6:33,496,596...33,507,626
Ensembl chr 6:33,503,217...33,507,542
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cellular developmental process 4459
        cell differentiation 4363
          tendon cell differentiation 5
            negative regulation of tendon cell differentiation 0
            positive regulation of tendon cell differentiation 1
            regulation of tendon cell differentiation + 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      anatomical structure development 6269
        tissue development 2099
          connective tissue development 303
            tendon development 8
              tendon formation 5
                tendon cell differentiation 5
                  negative regulation of tendon cell differentiation 0
                  positive regulation of tendon cell differentiation 1
                  regulation of tendon cell differentiation + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.