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ONTOLOGY REPORT - ANNOTATIONS


Term:tendon cell differentiation
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Accession:GO:0035990 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.
Synonyms:exact_synonym: muscle attachment cell differentiation
 related_synonym: tenocyte differentiation



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tendon cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:4418577|PMID:20059955)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:20059955 GO_REF:0000024 GO_REF:0000107 MGI:4418577 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Mkx mohawk homeobox acts_upstream_of_or_within ISO
IMP
MGI:5287572 (MGI:5287220|PMID:20696843) RGD PMID:20696843 PMID:27370800 MGI:5287220, RGD:40924660 NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124
JBrowse link
G Scx scleraxis bHLH transcription factor involved_in ISO (MGI:3715390|PMID:17567668), (MGI:4418577|PMID:20059955) RGD PMID:17567668 PMID:20059955 MGI:3715390 MGI:4418577 NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626
JBrowse link
G Tnmd tenomodulin involved_in IEP PMID:21412429 UniProt PMID:21412429 RGD:8553701 NCBI chr  X:97,057,137...97,072,634
Ensembl chr  X:97,057,137...97,072,634
JBrowse link
positive regulation of tendon cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdf7 growth differentiation factor 7 involved_in ISO (MGI:5294519|PMID:21412429) RGD PMID:21412429 MGI:5294519 NCBI chr 6:31,171,495...31,182,447
Ensembl chr 6:31,178,119...31,182,447
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      cellular developmental process 4482
        cell differentiation 4387
          tendon cell differentiation 5
            negative regulation of tendon cell differentiation 0
            positive regulation of tendon cell differentiation 1
            regulation of tendon cell differentiation + 1
Path 2
Term Annotations click to browse term
  biological_process 19390
    developmental process 6778
      anatomical structure development 6203
        tissue development 2079
          connective tissue development 310
            tendon development 8
              tendon formation 5
                tendon cell differentiation 5
                  negative regulation of tendon cell differentiation 0
                  positive regulation of tendon cell differentiation 1
                  regulation of tendon cell differentiation + 1
paths to the root