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ONTOLOGY REPORT - ANNOTATIONS

Term:tendon cell differentiation
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Accession:GO:0035990 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.
Synonyms:exact_synonym: muscle attachment cell differentiation
 related_synonym: tenocyte differentiation


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tendon cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISS
ISO 		GO_REF:0000107
GO_REF:0000024
(PMID:20059955) 		Ensembl
UniProt
RGD		 PMID:20059955 GO_REF:0000024 GO_REF:0000107 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Mkx mohawk homeobox acts_upstream_of_or_within IMP
ISO 		MGI:5287572 (PMID:20696843) RGD PMID:20696843 PMID:27370800 RGD:40924660 NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124 		JBrowse link
G Scx scleraxis bHLH transcription factor involved_in ISO (PMID:17567668), (PMID:20059955) RGD PMID:17567668 PMID:20059955 NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626 		JBrowse link
G Tnmd tenomodulin involved_in IEP PMID:21412429 UniProt PMID:21412429 RGD:8553701 NCBI chr  X:97,057,137...97,072,634
Ensembl chr  X:97,057,137...97,072,634 		JBrowse link
positive regulation of tendon cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdf7 growth differentiation factor 7 involved_in ISO (PMID:21412429) RGD PMID:21412429 NCBI chr 6:31,171,495...31,182,484
Ensembl chr 6:31,178,119...31,182,447 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:36905926)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:36905926 GO_REF:0000024 GO_REF:0000107 NCBI chr13:50,865,253...50,985,107
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      cellular developmental process 4838
        cell differentiation 4837
          tendon cell differentiation 6
            negative regulation of tendon cell differentiation 0
            positive regulation of tendon cell differentiation 2
            regulation of tendon cell differentiation + 2
Path 2
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure development 6656
        tissue development 2325
          connective tissue development 352
            tendon development 9
              tendon formation 6
                tendon cell differentiation 6
                  negative regulation of tendon cell differentiation 0
                  positive regulation of tendon cell differentiation 2
                  regulation of tendon cell differentiation + 2
paths to the root