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ONTOLOGY REPORT - ANNOTATIONS


Term:endodermal cell differentiation
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Accession:GO:0035987 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
Synonyms:exact_synonym: endoderm cell differentiation


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endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col11a1 collagen type XI alpha 1 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936730:466,912...680,823 JBrowse link
G Col12a1 collagen type XII alpha 1 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936788:533,811...645,821 JBrowse link
G Col4a2 collagen type IV alpha 2 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936472:2,270,836...2,416,324 JBrowse link
G Col6a1 collagen type VI alpha 1 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936778:515,600...530,828 JBrowse link
G Col7a1 collagen type VII alpha 1 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936529:348,938...381,701 JBrowse link
G Col8a1 collagen type VIII alpha 1 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936630:3,443,085...3,590,430 JBrowse link
G Fn1 fibronectin 1 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936586:1,708,803...1,773,372 JBrowse link
G Gata6 GATA binding protein 6 acts_upstream_of_or_within ISO (MGI:1315079|PMID:9832509) MGI PMID:9832509 MGI:1315079 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO (PMID:17624332) UniProt PMID:17624332 NCBI chrNW_004936545:3,944,419...3,958,289 JBrowse link
G Hsbp1 heat shock factor binding protein 1 acts_upstream_of_or_within ISO (MGI:5553204|PMID:24380799) MGI PMID:24380799 MGI:5553204 NCBI chrNW_004936641:3,911,943...3,916,397 JBrowse link
G Inhba inhibin subunit beta A involved_in ISO (PMID:21828274) BHF-UCL PMID:21828274 NCBI chrNW_004936478:16,878,725...16,884,065 JBrowse link
G Itga4 integrin subunit alpha 4 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936509:10,215,283...10,293,653 JBrowse link
G Itga5 integrin subunit alpha 5 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936512:11,588,818...11,612,580 JBrowse link
G Itga7 integrin subunit alpha 7 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936646:160,661...179,454 JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936778:1,286,475...1,311,184 JBrowse link
G Itgb5 integrin subunit beta 5 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936725:417,824...530,993 JBrowse link
G Lamb1 laminin subunit beta 1 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936479:16,177,200...16,245,268 JBrowse link
G Lamb3 laminin subunit beta 3 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936557:3,429,488...3,487,995 JBrowse link
G LOC101971816 laminin subunit alpha-3 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936550:3,121,163...3,357,517 JBrowse link
G Mixl1 Mix paired-like homeobox involved_in ISO (MGI:5447921|PMID:19038793) BHF-UCL PMID:19038793 MGI:5447921 NCBI chrNW_004936526:2,984,900...2,989,494 JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936722:1,447,189...1,457,632 JBrowse link
G Mmp15 matrix metallopeptidase 15 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936475:9,951,876...9,971,631 JBrowse link
G Mmp2 matrix metallopeptidase 2 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936551:5,228,950...5,238,948 JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (PMID:21741376) BHF-UCL PMID:21741376 NCBI chrNW_004936521:8,171,146...8,178,802 JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase involved_in ISO (MGI:5908786|PMID:25242323) UniProt PMID:25242323 MGI:5908786 NCBI chrNW_004936596:795,940...898,823 JBrowse link
G Vtn vitronectin involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936538:4,522,275...4,525,245 JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc73 cell division cycle 73 involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004936638:1,365,457...1,482,497 JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO (MGI:3625553|PMID:12194849) MGI PMID:12194849 MGI:3625553 NCBI chrNW_004936473:29,999,542...30,034,610 JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004936528:7,585,937...7,613,022 JBrowse link
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004936471:13,753,061...13,783,990 JBrowse link
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004936661:2,236,121...2,241,086 JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (MGI:1355046|PMID:10742100) MGI PMID:10742100 MGI:1355046 NCBI chrNW_004936837:827,568...838,933 JBrowse link
G Rtf1 RTF1 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004936471:4,770,060...4,829,562 JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 acts_upstream_of_or_within ISO (MGI:4442295|PMID:20308546) MGI PMID:20308546 MGI:4442295 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within ISO (MGI:4442295|PMID:20308546) MGI PMID:20308546 MGI:4442295 NCBI chrNW_004936496:1,248,582...1,251,406 JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin acts_upstream_of_or_within ISO (MGI:4887279|PMID:21245162) MGI PMID:21245162 MGI:4887279 NCBI chrNW_004936473:18,825,969...18,833,179 JBrowse link
G Hnf1b HNF1 homeobox B acts_upstream_of_or_within ISO (MGI:3807614|PMID:18635606) MGI PMID:18635606 MGI:3807614 NCBI chrNW_004936490:649,551...702,448 JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (PMID:20713518) MGI PMID:20713518 NCBI chrNW_004936892:181,834...187,691 JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:20713518) MGI PMID:20713518 NCBI chrNW_004936837:827,568...838,933 JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (MGI:4946573|PMID:21305474) BHF-UCL PMID:21305474 MGI:4946573 NCBI chrNW_004936496:1,248,582...1,251,406 JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (PMID:21245162) MGI PMID:21245162 NCBI chrNW_004936566:1,630,698...1,632,607 JBrowse link
negative regulation of endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col5a1 collagen type V alpha 1 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936669:2,474,381...2,613,541 JBrowse link
G Col5a2 collagen type V alpha 2 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chrNW_004936506:8,739,475...8,873,073 JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) BHF-UCL PMID:18593560 MGI:4441249 NCBI chrNW_004936483:15,533,264...15,534,576 JBrowse link
positive regulation of endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101971629 core histone macro-H2A.1 involved_in ISO (PMID:23595991) UniProt PMID:23595991 NCBI chrNW_004936597:2,496,489...2,556,352 JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chrNW_004936787:307,290...309,963 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12130
    cellular process 11319
      cellular developmental process 3715
        cell differentiation 3652
          endodermal cell differentiation 46
            endodermal cell fate commitment + 15
            negative regulation of endodermal cell differentiation + 3
            positive regulation of endodermal cell differentiation 1
            regulation of endodermal cell differentiation + 5
Path 2
Term Annotations click to browse term
  biological_process 12130
    developmental process 5716
      anatomical structure development 5344
        multicellular organism development 4894
          embryo development 1183
            embryonic morphogenesis 637
              gastrulation 179
                formation of primary germ layer 117
                  endoderm formation 52
                    endodermal cell differentiation 46
                      endodermal cell fate commitment + 15
                      negative regulation of endodermal cell differentiation + 3
                      positive regulation of endodermal cell differentiation 1
                      regulation of endodermal cell differentiation + 5
paths to the root