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ONTOLOGY REPORT - ANNOTATIONS


Term:endodermal cell differentiation
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Accession:GO:0035987 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
Synonyms:exact_synonym: endoderm cell differentiation



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endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col11a1 collagen type XI alpha 1 chain involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
JBrowse link
G Col12a1 collagen type XII alpha 1 chain involved_in IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:23154389)
Ensembl
RGD
PMID:23154389 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686
JBrowse link
G Col4a2 collagen type IV alpha 2 chain involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
JBrowse link
G Col6a1 collagen type VI alpha 1 chain involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Col7a1 collagen type VII alpha 1 chain involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 8:109,604,877...109,637,252
Ensembl chr 8:109,604,861...109,637,252
JBrowse link
G Col8a1 collagen type VIII alpha 1 chain involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424
JBrowse link
G Fn1 fibronectin 1 involved_in ISO
IEA
(PMID:23154389)
GO_REF:0000107
RGD
Ensembl
PMID:23154389 GO_REF:0000107 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gata6 GATA binding protein 6 acts_upstream_of_or_within ISO MGI:2177785 (MGI:1315079|PMID:9832509) RGD PMID:9832509 MGI:1315079 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO
ISS
(PMID:17624332)
GO_REF:0000024
RGD
UniProt
PMID:17624332 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hsbp1 heat shock factor binding protein 1 acts_upstream_of_or_within ISO (MGI:5553204|PMID:24380799) RGD PMID:24380799 MGI:5553204 NCBI chr19:47,401,039...47,405,373
Ensembl chr19:47,400,966...47,435,821
JBrowse link
G Inhba inhibin subunit beta A involved_in ISO (PMID:21828274) RGD PMID:21828274 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Itga4 integrin subunit alpha 4 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itga5 integrin subunit alpha 5 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itga7 integrin subunit alpha 7 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450
JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Itgb5 integrin subunit beta 5 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
JBrowse link
G Lama3 laminin subunit alpha 3 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
JBrowse link
G Lamb1 laminin subunit beta 1 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamb3 laminin subunit beta 3 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Mixl1 Mix paired-like homeobox 1 involved_in ISO (MGI:5447921|PMID:19038793) RGD PMID:19038793 MGI:5447921 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065
JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp15 matrix metallopeptidase 15 involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943
JBrowse link
G Mmp2 matrix metallopeptidase 2 involved_in ISO
IEA
(PMID:23154389)
GO_REF:0000107
RGD
Ensembl
PMID:23154389 GO_REF:0000107 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO
GO_REF:0000107
(PMID:23154389)
Ensembl
RGD
PMID:23154389 GO_REF:0000107 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in IEA
ISO
GO_REF:0000107
(PMID:23154389)
Ensembl
RGD
PMID:23154389 GO_REF:0000107 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (PMID:21741376) RGD PMID:21741376 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase involved_in ISO (MGI:5908786|PMID:25242323) RGD PMID:25242323 MGI:5908786 NCBI chr 8:110,511,808...110,597,489
Ensembl chr 8:110,511,772...110,597,489
JBrowse link
G Vtn vitronectin involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc73 cell division cycle 73 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3849235|PMID:19345177)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:19345177 GO_REF:0000024 GO_REF:0000107 MGI:3849235 NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1858007|MGI:2148567 (MGI:3625553|PMID:12194849)
Ensembl
RGD
PMID:12194849 GO_REF:0000107 MGI:3625553 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) RGD PMID:19345177 MGI:3849235 NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303
JBrowse link
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component involved_in ISS
ISO
GO_REF:0000024
(MGI:3849235|PMID:19345177)
UniProt
RGD
PMID:19345177 GO_REF:0000024 MGI:3849235 NCBI chr 8:76,199,547...76,223,983
Ensembl chr 8:76,199,099...76,223,983
JBrowse link
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component involved_in ISS
ISO
GO_REF:0000024
(MGI:3849235|PMID:19345177)
UniProt
RGD
PMID:19345177 GO_REF:0000024 MGI:3849235 NCBI chr 1:83,683,654...83,689,233
Ensembl chr 1:83,668,813...83,689,237
JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (MGI:1355046|PMID:10742100) RGD PMID:10742100 MGI:1355046 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) involved_in ISO (MGI:3849235|PMID:19345177) RGD PMID:19345177 MGI:3849235 NCBI chr 3:106,659,363...106,718,970
Ensembl chr 3:106,659,308...106,718,970
JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:4442295|PMID:20308546)
Ensembl
RGD
PMID:20308546 GO_REF:0000107 MGI:4442295 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within ISO (MGI:4442295|PMID:20308546) RGD PMID:20308546 MGI:4442295 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3774028 (MGI:4887279|PMID:21245162)
RGD PMID:21245162 PMID:21873635 MGI:4887279, RGD:13792537 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316
JBrowse link
G Hnf1b HNF1 homeobox B acts_upstream_of_or_within ISO MGI:1857856 (MGI:3807614|PMID:18635606) RGD PMID:18635606 MGI:3807614 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888
JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (PMID:20713518) RGD PMID:20713518 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:20713518) RGD PMID:20713518 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (MGI:4946573|PMID:21305474) RGD PMID:21305474 MGI:4946573 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (PMID:21245162) RGD PMID:21245162 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
negative regulation of endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col5a1 collagen type V alpha 1 chain involved_in ISO
IEA
(PMID:23154389)
GO_REF:0000107
RGD
Ensembl
PMID:23154389 GO_REF:0000107 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
JBrowse link
G Col5a2 collagen type V alpha 2 chain involved_in ISO (PMID:23154389) RGD PMID:23154389 NCBI chr 9:47,448,736...47,598,396
Ensembl chr 9:47,448,736...47,598,154
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
positive regulation of endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Macroh2a1 macroH2A.1 histone involved_in ISO (PMID:23595991) RGD PMID:23595991 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19391
    cellular process 18252
      cellular developmental process 4483
        cell differentiation 4388
          endodermal cell differentiation 46
            endodermal cell fate commitment + 15
            negative regulation of endodermal cell differentiation + 3
            positive regulation of endodermal cell differentiation 1
            regulation of endodermal cell differentiation + 5
Path 2
Term Annotations click to browse term
  biological_process 19391
    developmental process 6775
      anatomical structure development 6201
        multicellular organism development 5638
          embryo development 1315
            embryonic morphogenesis 689
              gastrulation 206
                formation of primary germ layer 128
                  endoderm formation 56
                    endodermal cell differentiation 46
                      endodermal cell fate commitment + 15
                      negative regulation of endodermal cell differentiation + 3
                      positive regulation of endodermal cell differentiation 1
                      regulation of endodermal cell differentiation + 5
paths to the root