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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to topologically incorrect protein
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Accession:GO:0035967 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.
Synonyms:related_synonym: cellular response to misfolded or unfolded protein


show annotations for term's descendants           Sort by:
cellular response to topologically incorrect protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:16192271) RGD PMID:16192271 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
cellular response to misfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 involved_in ISO
ISS		 (MGI:5318000|PMID:21855799)
GO_REF:0000024		 RGD
UniProt		 PMID:21855799 GO_REF:0000024 MGI:5318000 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 involved_in ISO
IBA		 (PMID:21148293), (PMID:21150129)
PMID:21873635		 RGD PMID:21148293 PMID:21150129 PMID:21873635 RGD:13792537 NCBI chr20:27,828,216...27,846,428
Ensembl chr20:27,828,235...27,846,427 		JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490 		JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:27,269,345...27,303,471
Ensembl chr18:27,269,355...27,298,344 		JBrowse link
G Hdac6 histone deacetylase 6 acts_upstream_of_or_within ISO MGI:3776868 (MGI:3757892|PMID:17785525) RGD PMID:17785525 MGI:3757892 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 acts_upstream_of_or_within IDA PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IBA
ISO		 PMID:21873635
(MGI:5318000|PMID:21855799)
(PMID:16831871)		 RGD PMID:16831871 PMID:21855799 PMID:21873635 MGI:5318000, RGD:13792537 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W involved_in ISS
ISO		 GO_REF:0000024
(MGI:5318000|PMID:21855799)		 UniProt
RGD		 PMID:21855799 GO_REF:0000024 MGI:5318000 NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965 		JBrowse link
cellular response to unfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 involved_in ISO (PMID:18006506) RGD PMID:18006506 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Daxx death-domain associated protein involved_in ISO
ISS		 (PMID:15016915)
GO_REF:0000024		 RGD
UniProt		 PMID:15016915 GO_REF:0000024 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Derl1 derlin 1 acts_upstream_of_or_within ISO (MGI:4361100|PMID:19509052) RGD PMID:19509052 MGI:4361100 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:19328063), (PMID:20625543) RGD PMID:19328063 PMID:20625543 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Hsc70-ps1 heat shock cognate protein 70, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:164,044,226...164,046,344
Ensembl chr 2:164,044,261...164,046,336 		JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:15016915) RGD PMID:15016915 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa13 heat shock protein family A (Hsp70) member 13 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895 		JBrowse link
G Hspa14 heat shock protein family A (Hsp70) member 14 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:74,728,945...74,749,730
Ensembl chr17:74,728,899...74,749,727 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in IBA
ISO		 PMID:21873635
(PMID:20625543)		 RGD PMID:20625543 PMID:21873635 RGD:13792537 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in IBA
ISO		 PMID:21873635
(PMID:20625543)		 RGD PMID:20625543 PMID:21873635 RGD:13792537 NCBI chr20:3,870,765...3,873,221 JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 involved_in IBA
ISO		 PMID:21873635
(PMID:18006506)		 RGD PMID:18006506 PMID:21873635 RGD:13792537 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185 		JBrowse link
G Optn optineurin involved_in ISO
IEA
ISS		 (PMID:27534431)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27534431 GO_REF:0000024 GO_REF:0000107 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO GO:0034620 (MGI:5517729|PMID:23847051) RGD PMID:23847051 MGI:5517729 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:5437551|PMID:22795130)
PMID:21873635
(PMID:22795130)		 UniProt
RGD		 PMID:22795130 PMID:21873635 GO_REF:0000024 MGI:5437551, RGD:13792537 NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689 		JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5909200|PMID:27740623)
(PMID:27740623)		 UniProt
RGD		 PMID:27740623 GO_REF:0000024 MGI:5909200 NCBI chr 4:179,518,127...179,550,154
Ensembl chr 4:179,518,130...179,550,154 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO
IBA		 (PMID:19328063)
PMID:21873635
(MGI:3840374|PMID:19328063)		 RGD PMID:19328063 PMID:21873635 MGI:3840374, RGD:13792537 NCBI chr 7:130,512,428...130,543,637
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Umod uromodulin acts_upstream_of_or_within ISO (MGI:5916257|PMID:28437467) RGD PMID:28437467 MGI:5916257 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
cytoplasm protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf126 ring finger protein 126 involved_in ISO (PMID:24981174) RGD PMID:24981174 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO
IBA		 (PMID:17157811)
PMID:21873635		 RGD PMID:17157811 PMID:21873635 RGD:13792537 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Atf3 activating transcription factor 3 involved_in ISO (MGI:3722921|PMID:14729979) RGD PMID:14729979 MGI:3722921 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5496937|PMID:23624402)		 UniProt
RGD		 PMID:23624402 GO_REF:0000024 MGI:5496937 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atf6b activating transcription factor 6 beta involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5607242|PMID:17612490)		 UniProt
RGD		 PMID:17612490 GO_REF:0000024 MGI:5607242 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713 		JBrowse link
G Casp12 caspase 12 acts_upstream_of_or_within ISO (MGI:1858648|PMID:10882126) RGD PMID:10882126 MGI:1858648 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Ccnd1 cyclin D1 acts_upstream_of_or_within ISO (MGI:3620306|PMID:16176978) RGD PMID:16176978 MGI:3620306 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
ISS		 (PMID:23152784)
GO_REF:0000024		 RGD
UniProt		 PMID:23152784 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4438316|PMID:19767743)		 UniProt
RGD		 PMID:19767743 GO_REF:0000024 MGI:4438316 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2654034|MGI:5441015 (MGI:3525819|PMID:15601821), (MGI:6270315|PMID:30188326)
(MGI:5496937|PMID:23624402)		 UniProt
RGD		 PMID:15601821 PMID:23624402 PMID:30188326 GO_REF:0000024 MGI:3525819 MGI:5496937 MGI:6270315 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Derl1 derlin 1 involved_in ISO
IBA		 (PMID:15215856)
PMID:21873635		 RGD PMID:15215856 PMID:21873635 RGD:13792537 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Derl2 derlin 2 involved_in IBA
ISO		 PMID:21873635
(PMID:16449189)		 RGD PMID:16449189 PMID:21873635 RGD:13792537 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518 		JBrowse link
G Derl3 derlin 3 involved_in ISO
IBA		 (PMID:16449189)
PMID:21873635		 RGD PMID:16449189 PMID:21873635 RGD:13792537 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 acts_upstream_of_or_within ISO (MGI:3511630|PMID:15542627) RGD PMID:15542627 MGI:3511630 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2177666 (MGI:1333015|PMID:9930704), (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:2677605|PMID:14517290), (MGI:3511630|PMID:15542627), (MGI:3583403|PMID:15911877), (MGI:3620306|PMID:16176978)
(PMID:10677345), (PMID:11907036), (PMID:22169477)		 UniProt
RGD		 PMID:9930704 PMID:10677345 PMID:10882126 PMID:11430819 PMID:11907036 More... GO_REF:0000024 MGI:1333015 MGI:1858648 MGI:2136067 MGI:2677605 MGI:3511630 MGI:3583403 MGI:3620306 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO MGI:2387965 (MGI:3620306|PMID:16176978) RGD PMID:16176978 MGI:3620306 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480 		JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:27566589)
GO_REF:0000107		 RGD
Ensembl		 PMID:27566589 GO_REF:0000107 NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 acts_upstream_of_or_within ISO (MGI:1858648|PMID:10882126), (MGI:2136067|PMID:11430819), (MGI:3525819|PMID:15601821) RGD PMID:10882126 PMID:11430819 PMID:15601821 MGI:1858648 MGI:2136067 MGI:3525819 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within ISO (MGI:3525819|PMID:15601821) RGD PMID:15601821 MGI:3525819 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Fgf21 fibroblast growth factor 21 IEP RGD PMID:23123503 RGD:10401883 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in
acts_upstream_of_or_within		 IMP
IBA
ISO		 PMID:21873635
(MGI:1913176|PMID:10922362)		 RGD PMID:10922362 PMID:15102845 PMID:21873635 MGI:1913176, RGD:1304324, RGD:13792537 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Herpud2 HERPUD family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:23,573,374...23,617,874
Ensembl chr 8:23,573,379...23,617,874 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in IBA
ISO		 PMID:21873635
(MGI:4437543|PMID:19816510)		 RGD PMID:19816510 PMID:21873635 MGI:4437543, RGD:13792537 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:3583403|PMID:15911877) RGD PMID:15911877 MGI:3583403 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 acts_upstream_of_or_within ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745 		JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IBA		 (PMID:23103912)
PMID:21873635		 RGD PMID:23103912 PMID:21873635 RGD:13792537 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A acts_upstream_of_or_within IEP
ISO		 MGI:2652765 (MGI:3525819|PMID:15601821) RGD PMID:15601821 PMID:22154936 PMID:18266951 MGI:3525819, RGD:9999171, RGD:9999413 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
ISS		 (PMID:22169477)
GO_REF:0000024		 RGD
UniProt		 PMID:22169477 GO_REF:0000024 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA
IBA		 (PMID:15215856)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:15215856 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:3652355 (MGI:3619104|PMID:16415102)
PMID:21873635		 RGD PMID:16415102 PMID:21873635 MGI:3619104, RGD:13792537 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116 		JBrowse link
G Serp2 stress-associated endoplasmic reticulum protein family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:51,879,884...51,903,965
Ensembl chr15:51,879,877...51,904,785 		JBrowse link
G Stc2 stanniocalcin 2 acts_upstream_of_or_within ISO (MGI:3511371|PMID:15485913) RGD PMID:15485913 MGI:3511371 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (MGI:5582182|PMID:12150907) RGD PMID:12150907 MGI:5582182 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Tbl2 transducin (beta)-like 2 involved_in ISO
IBA		 (PMID:25393282)
PMID:21873635		 RGD PMID:25393282 PMID:21873635 RGD:13792537 NCBI chr12:21,517,600...21,532,114
Ensembl chr12:21,520,682...21,531,896 		JBrowse link
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:5008116 (MGI:6270315|PMID:30188326)
PMID:21873635		 RGD PMID:30188326 PMID:21873635 MGI:6270315, RGD:13792537 NCBI chr15:100,000,157...100,056,573
Ensembl chr15:100,000,152...100,056,543 		JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS		 (PMID:16891305)
GO_REF:0000024		 RGD
UniProt		 PMID:16891305 GO_REF:0000024 NCBI chr 3:162,536,090...162,578,738
Ensembl chr 3:162,535,905...162,573,763 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IBA
ISO		 PMID:21873635
(MGI:3629256|PMID:16571599), (MGI:4999711|PMID:19911006)		 RGD PMID:16571599 PMID:19911006 PMID:21873635 MGI:3629256 MGI:4999711, RGD:13792537 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in IDA
ISO		 (MGI:5573106|PMID:24753614), (MGI:5607242|PMID:17612490) RGD PMID:17612490 PMID:24753614 PMID:15171721 MGI:5573106 MGI:5607242, RGD:1304536 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO
IBA
ISS		 (PMID:19818707)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:19818707 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:42,175,313...42,177,030
Ensembl chr13:42,174,820...42,177,205 		JBrowse link
ER-associated misfolded protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aup1 AUP1, lipid droplet regulating VLDL assembly factor involved_in ISO
ISS		 (PMID:21857022)
GO_REF:0000024		 RGD
UniProt		 PMID:21857022 GO_REF:0000024 NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISO
IEA
ISS		 (PMID:23129660), (PMID:24981174)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23129660 PMID:24981174 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:24089527) RGD PMID:24089527 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Ngly1 N-glycanase 1 IMP RGD PMID:32259258 RGD:39457703 NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630 		JBrowse link
G Rnf185 ring finger protein 185 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864 		JBrowse link
G Rnf5 ring finger protein 5 involved_in ISO
IBA		 (PMID:19269966)
PMID:21873635		 RGD PMID:19269966 PMID:21873635 RGD:13792537 NCBI chr20:4,145,539...4,147,985
Ensembl chr20:4,145,507...4,147,985 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 acts_upstream_of_or_within IMP PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Tor1a torsin family 1, member A involved_in ISS
ISO		 GO_REF:0000024
(MGI:3712415|PMID:17200151)		 UniProt
RGD		 PMID:17200151 GO_REF:0000024 MGI:3712415 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in IBA
ISO		 PMID:21873635
(PMID:24089527)		 RGD PMID:24089527 PMID:21873635 RGD:13792537 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:38,355,229...38,468,473
Ensembl chr 9:38,359,089...38,468,467 		JBrowse link
G Vcp valosin-containing protein involved_in IBA
ISO		 PMID:21873635
(PMID:24089527)		 RGD PMID:24089527 PMID:21873635 RGD:13792537 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO
IBA		 (PMID:11779465), (PMID:19328063), (PMID:28128204), (PMID:29198525), (PMID:9637683)
PMID:21873635
(MGI:5571560|PMID:24508390), (MGI:6114871|PMID:25164867)		 RGD PMID:9637683 PMID:11779465 PMID:19328063 PMID:24508390 PMID:25164867 More... MGI:5571560 MGI:6114871, RGD:13792537 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IEA		 (PMID:23103912)
GO_REF:0000107		 RGD
Ensembl		 PMID:23103912 GO_REF:0000107 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (MGI:5616322|PMID:15465829) RGD PMID:15465829 MGI:5616322 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS		 (PMID:20940299)
GO_REF:0000024		 RGD
UniProt		 PMID:20940299 GO_REF:0000024 NCBI chr 3:162,536,090...162,578,738
Ensembl chr 3:162,535,905...162,573,763 		JBrowse link
mitochondrial unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (PMID:28315685) RGD PMID:28315685 NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IGI
ISO		 PMID:20160352
(PMID:20160352)		 RGD PMID:20160352 PMID:20160352 RGD:10047363 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO (PMID:18391022) RGD PMID:18391022 NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999 		JBrowse link
G Mir199a2 microRNA 199a-2 acts_upstream_of ISO (PMID:24299514) RGD PMID:24299514 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:28128204), (PMID:32160526)
(MGI:5912977|PMID:28128204)		 RGD PMID:28128204 PMID:32160526 MGI:5912977 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
ISS		 (PMID:32160526)
GO_REF:0000024		 RGD
UniProt		 PMID:32160526 GO_REF:0000024 NCBI chr 5:38,962,721...38,995,134
Ensembl chr 5:38,962,171...38,995,199 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA		 (PMID:14676213)
PMID:21873635
UniProtKB:O55033 (MGI:5613478|PMID:14676213)		 RGD PMID:14676213 PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA		 UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
PMID:21873635		 RGD PMID:14676213 PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IBA		 (PMID:21216966)
(MGI:5619464|PMID:21216966)
PMID:21873635		 RGD PMID:21216966 PMID:21873635 MGI:5619464, RGD:13792537 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
nuclear protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akirin2 akirin 2 acts_upstream_of_positive_effect ISS
ISO		 GO_REF:0000024
(PMID:34711951)		 UniProt
RGD		 PMID:34711951 GO_REF:0000024 NCBI chr 5:49,108,231...49,122,566
Ensembl chr 5:49,108,220...49,122,568 		JBrowse link
G Cul3 cullin 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:27561354)		 UniProt
RGD		 PMID:27561354 GO_REF:0000024 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Klhl15 kelch-like family member 15 involved_in ISO
IBA
ISS		 (PMID:27561354)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:27561354 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3722921|PMID:14729979), (MGI:3798818|PMID:12667446)		 UniProt
RGD		 PMID:12667446 PMID:14729979 GO_REF:0000024 MGI:3722921 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) RGD PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS		 (PMID:33384352)
GO_REF:0000024		 RGD
UniProt		 PMID:33384352 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:32,052,542...32,061,596
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:16645094) RGD PMID:16645094 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
ISS		 (PMID:16645094)
GO_REF:0000024		 RGD
UniProt		 PMID:16645094 GO_REF:0000024 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:16645094), (PMID:28128204) RGD PMID:16645094 PMID:28128204 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA
ISS		 (PMID:20348923)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20348923 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA		 (PMID:16645094)
GO_REF:0000107		 RGD
Ensembl		 PMID:16645094 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS		 (PMID:26268696)
GO_REF:0000024		 RGD
UniProt		 PMID:26268696 GO_REF:0000024 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(MGI:5648772|PMID:26015568)		 UniProt
RGD		 PMID:26015568 GO_REF:0000024 MGI:5648772 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:5619464 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS		 (PMID:26268696)
GO_REF:0000024		 RGD
UniProt		 PMID:26268696 GO_REF:0000024 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein NOT|involved_in ISO (PMID:21803450) RGD PMID:21803450 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO (PMID:16940180)
(PMID:18391022)
(PMID:16940180), (PMID:18391022)		 RGD PMID:16940180 PMID:18391022 NCBI chr 5:57,817,835...57,823,171
Ensembl chr 5:57,817,832...57,824,390 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (MGI:5607229|PMID:20955178) RGD PMID:20955178 MGI:5607229 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:5605954|PMID:14559994), (MGI:5607243|PMID:16332684)
PMID:21873635
(MGI:5605954|PMID:14559994), (MGI:5607229|PMID:20955178), (MGI:5607243|PMID:16332684)
(PMID:25239945)		 UniProt
RGD		 PMID:14559994 PMID:16332684 PMID:20955178 PMID:25239945 PMID:21873635 GO_REF:0000024 MGI:5605954 MGI:5607229 MGI:5607243, RGD:13792537 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigbos1 PIGB opposite strand 1 involved_in ISO
ISS		 (PMID:31653868)
GO_REF:0000024		 RGD
UniProt		 PMID:31653868 GO_REF:0000024 NCBI chr 8:73,775,732...73,780,102
Ensembl chr 8:73,775,732...73,780,102 		JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:15234121) RGD PMID:15234121 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Ficd FIC domain protein adenylyltransferase involved_in ISO
ISS		 (PMID:25601083)
GO_REF:0000024		 RGD
UniProt		 PMID:25601083 GO_REF:0000024 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19898
    response to stimulus 10568
      response to stress 4281
        response to topologically incorrect protein 138
          cellular response to topologically incorrect protein 111
            cellular response to misfolded protein + 22
            cellular response to unfolded protein + 91
Path 2
Term Annotations click to browse term
  biological_process 19898
    response to stimulus 10568
      response to chemical 6106
        response to organic substance 3783
          response to topologically incorrect protein 138
            cellular response to topologically incorrect protein 111
              cellular response to misfolded protein + 22
              cellular response to unfolded protein + 91
paths to the root