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ONTOLOGY REPORT - ANNOTATIONS


Term:cellular response to topologically incorrect protein
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Accession:GO:0035967 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.
Synonyms:related_synonym: cellular response to misfolded or unfolded protein



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cellular response to topologically incorrect protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:16192271) RGD PMID:16192271 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441
JBrowse link
cellular response to misfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 involved_in ISO
IEA
ISS
(MGI:5318000|PMID:21855799)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:21855799 GO_REF:0000024 GO_REF:0000107 MGI:5318000 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:24089527)
Ensembl
RGD
PMID:24089527 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:24089527) RGD PMID:24089527 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
JBrowse link
G Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 involved_in ISO
IBA
(PMID:21148293), (PMID:21150129)
GO_REF:0000033
RGD
GO_Central
PMID:21148293 PMID:21150129 GO_REF:0000033 NCBI chr20:27,828,216...27,846,428
Ensembl chr20:27,828,235...27,846,427
JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490
JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:27,269,350...27,303,453
Ensembl chr18:27,269,355...27,298,344
JBrowse link
G Hdac6 histone deacetylase 6 acts_upstream_of_or_within ISO MGI:3776868 (PMID:17785525) RGD PMID:17785525 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 acts_upstream_of_or_within IDA PMID:23444373 MGI PMID:23444373 RGD:8554667 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO
IEA
(PMID:16831871)
GO_REF:0000118
(MGI:5318000|PMID:21855799)
RGD
TreeGrafter
PMID:16831871 PMID:21855799 GO_REF:0000118 MGI:5318000 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W involved_in ISS
ISO
GO_REF:0000024
(MGI:5318000|PMID:21855799)
UniProt
RGD
PMID:21855799 GO_REF:0000024 MGI:5318000 NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:24089527)
Ensembl
RGD
PMID:24089527 GO_REF:0000107 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087
JBrowse link
G Vcp valosin-containing protein involved_in ISO (PMID:24089527) RGD PMID:24089527 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
cellular response to unfolded protein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 involved_in ISO (PMID:18006506) RGD PMID:18006506 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Daxx death-domain associated protein involved_in ISO
IEA
ISS
(PMID:15016915)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15016915 GO_REF:0000024 GO_REF:0000107 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Derl1 derlin 1 acts_upstream_of_or_within ISO (PMID:19509052) RGD PMID:19509052 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:19328063), (PMID:20625543), (PMID:21317875) RGD PMID:19328063 PMID:20625543 PMID:21317875 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Hsf1 heat shock transcription factor 1 involved_in ISO (PMID:15016915) RGD PMID:15016915 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:20625543) RGD PMID:20625543 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 involved_in ISO
IBA
(PMID:18006506)
GO_REF:0000033
RGD
GO_Central
PMID:18006506 GO_REF:0000033 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
JBrowse link
G Optn optineurin involved_in ISO
IEA
ISS
(PMID:27534431)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:27534431 GO_REF:0000024 GO_REF:0000107 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO GO:0034620 (PMID:23847051) RGD PMID:23847051 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Rhbdd1 rhomboid domain containing 1 involved_in ISS
IBA
IEA
ISO
GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
(MGI:5437551|PMID:22795130)
(PMID:22795130)
UniProt
GO_Central
TreeGrafter
RGD
PMID:22795130 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 MGI:5437551 NCBI chr 9:83,630,037...83,748,690
Ensembl chr 9:83,630,063...83,748,689
JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5909200|PMID:27740623)
(PMID:27740623)
UniProt
RGD
PMID:27740623 GO_REF:0000024 MGI:5909200 NCBI chr 4:179,518,127...179,550,154
Ensembl chr 4:179,518,130...179,550,154
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in ISO
IBA
IEA
(PMID:19328063)
GO_REF:0000033
GO_REF:0000118
(MGI:3840374|PMID:19328063)
RGD
GO_Central
TreeGrafter
PMID:19328063 GO_REF:0000033 GO_REF:0000118 MGI:3840374 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633
JBrowse link
G Umod uromodulin acts_upstream_of_or_within ISO (PMID:28437467) RGD PMID:28437467 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
JBrowse link
cytoplasm protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf126 ring finger protein 126 involved_in ISO (PMID:24981174) RGD PMID:24981174 NCBI chr 7:9,939,359...9,946,963
Ensembl chr 7:9,938,229...9,946,738
JBrowse link
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor involved_in ISO
IBA
(PMID:17157811)
GO_REF:0000033
RGD
GO_Central
PMID:17157811 GO_REF:0000033 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
JBrowse link
G Atf3 activating transcription factor 3 involved_in ISO (MGI:3722921|PMID:14729979) RGD PMID:14729979 MGI:3722921 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:5496937|PMID:23624402)
UniProt
RGD
PMID:23624402 GO_REF:0000024 MGI:5496937 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 involved_in IBA
IEA
GO_REF:0000033
GO_REF:0000118
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atf6b activating transcription factor 6 beta involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 involved_in ISS
ISO
GO_REF:0000024
(MGI:5607242|PMID:17612490)
UniProt
RGD
PMID:17612490 GO_REF:0000024 MGI:5607242 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
JBrowse link
G Casp12 caspase 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:10882126)
Ensembl
RGD
PMID:10882126 GO_REF:0000107 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Ccnd1 cyclin D1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:16176978)
Ensembl
RGD
PMID:16176978 GO_REF:0000107 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
IEA
ISS
(PMID:23152784)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23152784 GO_REF:0000024 GO_REF:0000107 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO (PMID:16940180)
(PMID:18391022)
RGD PMID:16940180 PMID:18391022 NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4438316|PMID:19767743)
UniProt
RGD
PMID:19767743 GO_REF:0000024 MGI:4438316 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2654034|MGI:5441015 (PMID:15601821), (PMID:30188326)
(MGI:5496937|PMID:23624402)
UniProt
RGD
PMID:15601821 PMID:23624402 PMID:30188326 GO_REF:0000024 MGI:5496937 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Derl1 derlin 1 involved_in ISO
IBA
(PMID:15215856)
GO_REF:0000033
RGD
GO_Central
PMID:15215856 GO_REF:0000033 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
JBrowse link
G Derl2 derlin 2 involved_in ISO
IBA
(PMID:16449189)
GO_REF:0000033
RGD
GO_Central
PMID:16449189 GO_REF:0000033 NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518
JBrowse link
G Derl3 derlin 3 involved_in ISO
IBA
(PMID:16449189)
GO_REF:0000033
RGD
GO_Central
PMID:16449189 GO_REF:0000033 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 acts_upstream_of_or_within ISO (PMID:15542627) RGD PMID:15542627 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:2177666 (PMID:10882126), (PMID:11430819), (PMID:14517290), (PMID:15542627), (PMID:15911877), (PMID:16176978), (PMID:9930704)
(PMID:10677345), (PMID:11907036), (PMID:22169477)
UniProt
RGD
PMID:9930704 PMID:10677345 PMID:10882126 PMID:11430819 PMID:11907036 More... GO_REF:0000024 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO MGI:2387965 (PMID:16176978) RGD PMID:16176978 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630
JBrowse link
G ENSRNOG00000066502 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 9:2,759,881...2,760,635 JBrowse link
G ENSRNOG00000069918 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 9:2,654,884...2,655,638 JBrowse link
G ENSRNOG00000070059 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 9:2,698,519...2,699,273 JBrowse link
G ENSRNOG00000070668 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 9:3,071,123...3,071,876 JBrowse link
G Erlec1 endoplasmic reticulum lectin 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:104,655,745...104,693,508
Ensembl chr14:104,655,673...104,693,480
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:27566589)
GO_REF:0000107
RGD
Ensembl
PMID:27566589 GO_REF:0000107 NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 acts_upstream_of_or_within ISO (PMID:10882126), (PMID:11430819), (PMID:15601821) RGD PMID:10882126 PMID:11430819 PMID:15601821 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha acts_upstream_of_or_within ISO (PMID:15601821) RGD PMID:15601821 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Fgf21 fibroblast growth factor 21 IEP RGD PMID:23123503 RGD:10401883 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
(PMID:10922362)
GO_REF:0000033
RGD
GO_Central
PMID:10922362 PMID:15102845 GO_REF:0000033, RGD:1304324 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Herpud2 HERPUD family member 2 involved_in IEA
IBA
GO_REF:0000118
GO_REF:0000033
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 8:23,573,374...23,618,380
Ensembl chr 8:23,573,379...23,617,874
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO
IBA
IEA
(MGI:4437543|PMID:19816510)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:19816510 GO_REF:0000033 GO_REF:0000107 MGI:4437543 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hyou1 hypoxia up-regulated 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Ifnb1 interferon beta 1 IEP RGD PMID:18412159 RGD:401854236 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:15911877) RGD PMID:15911877 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 acts_upstream_of_or_within ISO (PMID:14517290) RGD PMID:14517290 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Os9 OS9, endoplasmic reticulum lectin involved_in IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IBA
(PMID:23103912)
GO_REF:0000033
RGD
GO_Central
PMID:23103912 GO_REF:0000033 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433
JBrowse link
G Parp6 poly (ADP-ribose) polymerase family, member 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:60,016,594...60,049,108
Ensembl chr 8:60,016,877...60,049,108
JBrowse link
G Parp8 poly (ADP-ribose) polymerase family, member 8 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:48,679,405...48,848,700
Ensembl chr 2:48,679,436...48,849,253
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A acts_upstream_of_or_within IEP
ISO
MGI:2652765 (PMID:15601821) RGD PMID:15601821 PMID:22154936 PMID:18266951 RGD:9999171, RGD:9999413 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
ISS
(PMID:22169477)
GO_REF:0000024
RGD
UniProt
PMID:22169477 GO_REF:0000024 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359
JBrowse link
G Selenos selenoprotein S involved_in ISO
IBA
IEA
(PMID:15215856)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
RGD
GO_Central
TreeGrafter
Ensembl
PMID:15215856 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000118
MGI:3652355 (PMID:16415102)
GO_REF:0000033
TreeGrafter
RGD
GO_Central
PMID:16415102 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116
JBrowse link
G Serp2 stress-associated endoplasmic reticulum protein family member 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:51,879,882...51,903,958
Ensembl chr15:51,879,877...51,904,785
JBrowse link
G Stc2 stanniocalcin 2 acts_upstream_of_or_within ISO (PMID:15485913) RGD PMID:15485913 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (MGI:5582182|PMID:12150907) RGD PMID:12150907 MGI:5582182 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
JBrowse link
G Tbl2 transducin (beta)-like 2 involved_in ISO
IBA
(PMID:25393282)
GO_REF:0000033
RGD
GO_Central
PMID:25393282 GO_REF:0000033 NCBI chr12:21,517,600...21,531,896
Ensembl chr12:21,520,682...21,531,896
JBrowse link
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:5008116 (PMID:30188326)
GO_Central
RGD
PMID:30188326 GO_REF:0000033 NCBI chr15:100,000,157...100,056,573
Ensembl chr15:100,000,152...100,056,543
JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS
(PMID:16891305)
GO_REF:0000024
RGD
UniProt
PMID:16891305 GO_REF:0000024 NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IBA
ISO
GO_REF:0000033
(MGI:3629256|PMID:16571599), (PMID:19911006)
GO_Central
RGD
PMID:16571599 PMID:19911006 GO_REF:0000033 MGI:3629256 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
JBrowse link
G Xbp1 X-box binding protein 1 involved_in IDA
ISO
ISS
(MGI:5573106|PMID:24753614), (MGI:5605954|PMID:14559994), (MGI:5607242|PMID:17612490), (MGI:5607243|PMID:16332684)
(PMID:25239945)
GO_REF:0000024
RGD
UniProt
PMID:14559994 PMID:16332684 PMID:17612490 PMID:24753614 PMID:25239945 More... GO_REF:0000024 MGI:5573106 MGI:5605954 MGI:5607242 MGI:5607243, RGD:1304536 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Yod1 YOD1 deubiquitinase involved_in ISO
IBA
ISS
(PMID:19818707)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:19818707 GO_REF:0000024 GO_REF:0000033 NCBI chr13:42,175,047...42,181,661
Ensembl chr13:42,174,820...42,177,205
JBrowse link
IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 involved_in IBA
IEA
GO_REF:0000033
GO_REF:0000118
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO
IBA
(PMID:11779465), (PMID:19328063), (PMID:28128204), (PMID:29198525), (PMID:9637683)
(MGI:6114871|PMID:25164867), (PMID:24508390)
GO_REF:0000033
RGD
GO_Central
PMID:9637683 PMID:11779465 PMID:19328063 PMID:24508390 PMID:25164867 More... GO_REF:0000033 MGI:6114871 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (PMID:24508390) RGD PMID:24508390 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 involved_in ISO
IEA
(PMID:23103912)
GO_REF:0000107
RGD
Ensembl
PMID:23103912 GO_REF:0000107 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (MGI:5616322|PMID:15465829) RGD PMID:15465829 MGI:5616322 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Vapb VAMP associated protein B and C involved_in ISO
ISS
(PMID:20940299)
GO_REF:0000024
RGD
UniProt
PMID:20940299 GO_REF:0000024 NCBI chr 3:162,535,974...162,578,747
Ensembl chr 3:162,535,905...162,573,763
JBrowse link
mitochondrial unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb10 ATP binding cassette subfamily B member 10 involved_in ISO (PMID:28315685) RGD PMID:28315685 NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753
JBrowse link
G ENSRNOG00000065699 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr14:100,606,613...100,607,588 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspd1l1 heat shock protein family D (Hsp60) member 1 like 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr18:1,587,931...1,590,330
Ensembl chr18:1,588,008...1,590,314
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IGI
ISO
PMID:20160352
(PMID:20160352)
RGD PMID:20160352 PMID:20160352 RGD:10047363 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO (PMID:18391022) RGD PMID:18391022 NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
JBrowse link
G Mir199a2 microRNA 199a-2 acts_upstream_of ISO (PMID:24299514) RGD PMID:24299514 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038
JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO
IBA
(PMID:28128204), (PMID:32160526)
GO_REF:0000033
(MGI:5912977|PMID:28128204)
RGD
GO_Central
PMID:28128204 PMID:32160526 GO_REF:0000033 MGI:5912977 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 involved_in ISO (PMID:24508390) RGD PMID:24508390 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
ISS
(PMID:32160526)
GO_REF:0000024
RGD
UniProt
PMID:32160526 GO_REF:0000024 NCBI chr 5:38,962,721...38,995,134
Ensembl chr 5:38,962,171...38,995,199
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA
(PMID:14676213)
GO_REF:0000033
UniProtKB:O55033 (MGI:5613478|PMID:14676213)
RGD
GO_Central
PMID:14676213 GO_REF:0000033 MGI:5613478 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA
UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
GO_REF:0000033
RGD
GO_Central
PMID:14676213 GO_REF:0000033 MGI:5613478 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IBA
IEA
(PMID:21216966)
(MGI:5619464|PMID:21216966)
GO_REF:0000033
GO_REF:0000118
RGD
GO_Central
TreeGrafter
PMID:21216966 GO_REF:0000033 GO_REF:0000118 MGI:5619464 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
nuclear protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akirin2 akirin 2 acts_upstream_of_positive_effect ISS
ISO
GO_REF:0000024
(PMID:34711951)
UniProt
RGD
PMID:34711951 GO_REF:0000024 NCBI chr 5:49,108,231...49,122,566
Ensembl chr 5:49,108,220...49,122,568
JBrowse link
G Cul3 cullin 3 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:27561354)
UniProt
Ensembl
RGD
PMID:27561354 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
JBrowse link
G Klhl15 kelch-like family member 15 involved_in ISO
IBA
ISS
(PMID:27561354)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:27561354 GO_REF:0000024 GO_REF:0000033 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:3722921|PMID:14729979), (MGI:3798818|PMID:12667446)
UniProt
RGD
PMID:12667446 PMID:14729979 GO_REF:0000024 MGI:3722921 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) RGD PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS
(PMID:33384352)
GO_REF:0000024
RGD
UniProt
PMID:33384352 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359
JBrowse link
G Rpap2 RNA polymerase II associated protein 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:30118681)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30118681 GO_REF:0000024 GO_REF:0000107 NCBI chr14:2,109,044...2,187,343
Ensembl chr14:2,109,053...2,187,350
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4456438 (PMID:28797121)
Ensembl
RGD
PMID:28797121 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO
IEA
(PMID:9837962)
GO_REF:0000107
RGD
Ensembl
PMID:9837962 GO_REF:0000107 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:16645094) RGD PMID:16645094 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO
ISS
(PMID:16645094)
GO_REF:0000024
RGD
UniProt
PMID:16645094 GO_REF:0000024 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:16645094), (PMID:28128204) RGD PMID:16645094 PMID:28128204 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA
ISS
(PMID:20348923)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20348923 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA
(PMID:16645094)
GO_REF:0000107
RGD
Ensembl
PMID:16645094 GO_REF:0000107 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS
(PMID:26268696)
GO_REF:0000024
RGD
UniProt
PMID:26268696 GO_REF:0000024 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
GO_REF:0000024
(MGI:5648772|PMID:26015568)
UniProt
RGD
PMID:26015568 GO_REF:0000024 MGI:5648772 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
(MGI:5619464|PMID:21216966)
GO_REF:0000107
RGD
Ensembl
PMID:21216966 GO_REF:0000107 MGI:5619464 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS
(PMID:26268696)
GO_REF:0000024
RGD
UniProt
PMID:26268696 GO_REF:0000024 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715
JBrowse link
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pigbos1 PIGB opposite strand 1 involved_in ISO
ISS
(PMID:31653868)
GO_REF:0000024
RGD
UniProt
PMID:31653868 GO_REF:0000024 NCBI chr 8:73,775,732...73,780,102
Ensembl chr 8:73,775,732...73,780,102
JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:15234121) RGD PMID:15234121 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Ficd FIC domain protein adenylyltransferase involved_in ISO
IEA
ISS
(PMID:25601083)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:25601083 GO_REF:0000024 GO_REF:0000107 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    response to stimulus 10871
      response to stress 4259
        response to topologically incorrect protein 132
          cellular response to topologically incorrect protein 107
            cellular response to misfolded protein + 16
            cellular response to unfolded protein + 93
Path 2
Term Annotations click to browse term
  biological_process 20292
    response to stimulus 10871
      response to chemical 6010
        response to organic substance 3700
          response to topologically incorrect protein 132
            cellular response to topologically incorrect protein 107
              cellular response to misfolded protein + 16
              cellular response to unfolded protein + 93
paths to the root