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ONTOLOGY REPORT - ANNOTATIONS

Term:aldosterone secretion
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Accession:GO:0035932 term browser browse the term
Definition:The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


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aldosterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within
involved_in		 ISO MGI:2136636 (MGI:3618038|PMID:9557921)
(MGI:5426321|PMID:22550170)		 RGD PMID:9557921 PMID:22550170 MGI:3618038 MGI:5426321 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 involved_in ISO MGI:5427702 (MGI:5426321|PMID:22550170) RGD PMID:22550170 MGI:5426321 NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
positive regulation of aldosterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 IDA RGD PMID:22538126 RGD:7242193 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G C1qtnf1 C1q and TNF related 1 involved_in ISO
IEA		 (PMID:18171693)
GO_REF:0000107		 RGD
Ensembl		 PMID:18171693 GO_REF:0000107 NCBI chr10:103,660,319...103,681,662
Ensembl chr10:103,660,327...103,681,660 		JBrowse link
G Dab2 DAB adaptor protein 2 IDA RGD PMID:17303656 RGD:7243836 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
renin-angiotensin regulation of aldosterone production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within IDA
ISO		 MGI:2136636 (MGI:1332965|PMID:10076178), (MGI:2385818|PMID:9852267) RGD PMID:9852267 PMID:10076178 PMID:21318332 MGI:1332965 MGI:2385818, RGD:5129178 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within IMP
ISO		 MGI:1857147 (MGI:2386466|PMID:12167595) RGD PMID:12167595 PMID:21318332 MGI:2386466, RGD:5129178 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:21318332 RGD:5129178 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Ren renin acts_upstream_of_or_within ISO (MGI:3848759|PMID:19293336) RGD PMID:19293336 MGI:3848759 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    localization 5545
      establishment of localization 4868
        transport 4676
          organic substance transport 2910
            organic hydroxy compound transport 351
              aldosterone secretion 8
                negative regulation of aldosterone secretion 0
                positive regulation of aldosterone secretion 3
                regulation of aldosterone secretion + 7
Path 2
Term Annotations click to browse term
  biological_process 19574
    localization 5545
      establishment of localization 4868
        transport 4676
          secretion 1185
            secretion by cell 992
              signal release 641
                hormone secretion 419
                  endocrine hormone secretion 78
                    steroid hormone secretion 37
                      corticosteroid hormone secretion 23
                        mineralocorticoid secretion 8
                          aldosterone secretion 8
                            negative regulation of aldosterone secretion 0
                            positive regulation of aldosterone secretion 3
                            regulation of aldosterone secretion + 7
paths to the root