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ONTOLOGY REPORT - ANNOTATIONS


Term:aldosterone secretion
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Accession:GO:0035932 term browser browse the term
Definition:The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


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aldosterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:1566502 RGD:6903876 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
positive regulation of aldosterone secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 IDA RGD PMID:22538126 RGD:7242193 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G C1qtnf1 C1q and TNF related 1 involved_in ISO
IEA
(PMID:18171693)
GO_REF:0000107
RGD
Ensembl
PMID:18171693 GO_REF:0000107 NCBI chr10:103,660,319...103,681,662
Ensembl chr10:103,660,327...103,681,660
JBrowse link
G Dab2 DAB adaptor protein 2 IDA RGD PMID:17303656 RGD:7243836 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
renin-angiotensin regulation of aldosterone production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen acts_upstream_of_or_within IDA
ISO
MGI:2136636 (MGI:1332965|PMID:10076178), (MGI:2385818|PMID:9852267) RGD PMID:9852267 PMID:10076178 PMID:21318332 MGI:1332965 MGI:2385818, RGD:5129178 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a acts_upstream_of_or_within IMP
ISO
MGI:1857147 (MGI:2386466|PMID:12167595) RGD PMID:12167595 PMID:21318332 MGI:2386466, RGD:5129178 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:21318332 RGD:5129178 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ren renin acts_upstream_of_or_within ISO (MGI:3848759|PMID:19293336) RGD PMID:19293336 MGI:3848759 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    localization 6447
      establishment of localization 4864
        transport 4700
          organic substance transport 2479
            organic hydroxy compound transport 306
              aldosterone secretion 7
                negative regulation of aldosterone secretion 0
                positive regulation of aldosterone secretion 3
                regulation of aldosterone secretion + 7
Path 2
Term Annotations click to browse term
  biological_process 19492
    localization 6447
      establishment of localization 4864
        transport 4700
          export from cell 1015
            secretion by cell 961
              signal release 622
                hormone secretion 394
                  endocrine hormone secretion 69
                    steroid hormone secretion 29
                      corticosteroid hormone secretion 21
                        mineralocorticoid secretion 7
                          aldosterone secretion 7
                            negative regulation of aldosterone secretion 0
                            positive regulation of aldosterone secretion 3
                            regulation of aldosterone secretion + 7
paths to the root