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ONTOLOGY REPORT - ANNOTATIONS


Term:vascular associated smooth muscle cell differentiation
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Accession:GO:0035886 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.
Synonyms:exact_synonym: VSMC differentiation;   vascular smooth muscle cell differentiation



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vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in IEA Ensembl GO_REF:0000107
G C3 complement C3 acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,499...72,528,112
JBrowse link
G CFD complement factor D acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383 NCBI chr 2:77,509,792...77,511,988
Ensembl chr 2:77,509,795...77,511,974
JBrowse link
G CFH complement factor H acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383
G EPC1 enhancer of polycomb homolog 1 ISO RGD PMID:22398275 RGD:9587795 NCBI chr10:42,835,280...42,946,859
Ensembl chr10:42,835,285...42,947,524
JBrowse link
G MRTFB myocardin related transcription factor B acts_upstream_of_or_within ISO (MGI:3607644|PMID:16204380) MGI PMID:16204380 MGI:3607644 NCBI chr 3:28,964,758...29,240,125
Ensembl chr 3:28,964,754...29,167,631
JBrowse link
G MYOCD myocardin involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:56,931,628...57,029,258
Ensembl chr12:56,931,317...57,029,538
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chr 6:28,666,458...28,806,432
Ensembl chr 6:28,617,445...28,872,058
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2136698|PMID:11439183) MGI
Ensembl
PMID:11439183 GO_REF:0000107 MGI:2136698 NCBI chr 7:74,918,982...74,929,688
Ensembl chr 7:74,918,982...74,931,348
JBrowse link
G PITX2 paired like homeodomain 2 acts_upstream_of_or_within ISO (MGI:3796777|PMID:18458156) MGI PMID:18458156 MGI:3796777 NCBI chr 8:111,697,364...111,723,295
Ensembl chr 8:111,698,664...111,723,298
JBrowse link
G QKI QKI, KH domain containing RNA binding acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3029686|PMID:14706070) MGI
Ensembl
PMID:14706070 GO_REF:0000107 MGI:3029686 NCBI chr 1:4,732,575...4,883,386
Ensembl chr 1:4,735,513...4,883,768
JBrowse link
aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) MGI PMID:19342595 MGI:5007924 NCBI chr 1:219,624,773...219,815,438
Ensembl chr 1:219,573,535...219,815,421
JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) MGI PMID:19342595 MGI:5007924 NCBI chr 2:69,717,175...69,810,301
Ensembl chr 2:69,662,238...69,810,298
JBrowse link
cardiac vascular smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4838384|PMID:20619341) Ensembl
Ensembl
MGI
PMID:20619341 GO_REF:0000107 MGI:4838384 NCBI chr 1:37,219,887...37,231,321
Ensembl chr 1:37,219,883...37,231,385
JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107
G VEGFA vascular endothelial growth factor A involved_in ISO (MGI:4461879|PMID:18093989) BHF-UCL PMID:18093989 MGI:4461879 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:55,322,016...55,327,600
Ensembl chr 7:55,322,010...55,325,732
JBrowse link
G MIR143 microRNA mir-143 acts_upstream_of_or_within ISO (MGI:4443305|PMID:19816508) MGI PMID:19816508 MGI:4443305 NCBI chr 2:150,578,738...150,578,817
Ensembl chr 2:150,578,738...150,578,817
JBrowse link
G MIR145 microRNA mir-145 acts_upstream_of_or_within ISO (MGI:4443305|PMID:19816508) MGI PMID:19816508 MGI:4443305 NCBI chr 2:150,580,126...150,580,211
Ensembl chr 2:150,580,126...150,580,211
JBrowse link
G MYOCD myocardin involved_in ISO PMID:16151017 BHF-UCL PMID:16151017 RGD:8554320 NCBI chr12:56,931,628...57,029,258
Ensembl chr12:56,931,317...57,029,538
JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3513738|PMID:15569937) Ensembl
Ensembl
MGI
PMID:15569937 GO_REF:0000107 MGI:3513738 NCBI chr 7:38,213,300...38,223,686
Ensembl chr 7:38,213,063...38,222,140
JBrowse link
negative regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR21 microRNA mir-21 involved_in ISO (PMID:22034194) BHF-UCL PMID:22034194 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR100 microRNA mir-100 involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr 9:49,157,909...49,157,988
Ensembl chr 9:49,157,909...49,157,988
JBrowse link
G MIR15B microRNA mir-15b involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr13:100,083,172...100,083,269
Ensembl chr13:100,083,172...100,083,269
JBrowse link
G MIR221 microRNA mir-221 involved_in ISO (PMID:18548003), (PMID:19088079) BHF-UCL PMID:18548003 PMID:19088079 NCBI chr  X:40,571,068...40,571,137
Ensembl chr  X:40,571,068...40,571,137
JBrowse link
G MIR26A microRNA mir-26a involved_in ISO (PMID:20857419) BHF-UCL PMID:20857419 NCBI chr 5:23,112,744...23,112,827
Ensembl chr 5:23,112,744...23,112,827
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:145,940,099...146,002,897
Ensembl chr 1:145,911,045...146,017,701
JBrowse link
G NFATC2 nuclear factor of activated T cells 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr17:52,743,570...52,907,373
Ensembl chr17:52,743,570...52,906,821
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:28,666,458...28,806,432
Ensembl chr 6:28,617,445...28,872,058
JBrowse link
G PDCD4 programmed cell death 4 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:121,271,824...121,334,767
Ensembl chr14:121,271,513...121,336,034
JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in IEA Ensembl
Ensembl
GO_REF:0000107 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
G PLA2G15 phospholipase A2 group XV involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:28,820,620...28,832,768 JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNMT1 DNA methyltransferase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G FGF9 fibroblast growth factor 9 involved_in ISO PMID:28259995 BHF-UCL PMID:28259995 RGD:13601993 NCBI chr11:1,554,648...1,581,938
Ensembl chr11:1,554,763...1,582,408
JBrowse link
positive regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTH cystathionine gamma-lyase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,435,690...142,486,367
JBrowse link
G EFEMP2 EGF containing fibulin extracellular matrix protein 2 involved_in ISO (MGI:4947512|PMID:20019329) UniProt PMID:20019329 MGI:4947512 NCBI chr 2:6,455,155...6,463,493
Ensembl chr 2:6,450,332...6,463,493
JBrowse link
positive regulation of cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPER1 G protein-coupled estrogen receptor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,982
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENG endoglin involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 8:41,402,334...41,492,306
Ensembl chr 8:41,402,043...41,493,735
JBrowse link
G MIR125B-1 microRNA mir-125b-1 involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr 9:49,109,435...49,109,514
Ensembl chr 9:49,109,435...49,109,514
JBrowse link
G MIR21 microRNA mir-21 involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR140 microRNA mir-140 involved_in ISO (PMID:27021683) BHF-UCL PMID:27021683 NCBI chr 6:17,077,530...17,077,599
Ensembl chr 6:17,077,507...17,077,620
JBrowse link
G SOD2 superoxide dismutase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SDC4 syndecan 4 NOT|involved_in ISO PMID:25089138 BHF-UCL PMID:25089138 RGD:11079193 NCBI chr17:47,650,387...47,670,499 JBrowse link
vascular associated smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
JBrowse link
G COMP cartilage oligomeric matrix protein involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5318950|PMID:21350216) Ensembl
Ensembl
MGI
PMID:21350216 GO_REF:0000107 MGI:5318950 NCBI chr 2:59,061,409...59,068,951
Ensembl chr 2:59,061,420...59,068,949
JBrowse link
G EDNRA endothelin receptor type A involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 8:81,210,750...81,279,053
Ensembl chr 8:81,209,327...81,276,853
JBrowse link
G EFEMP2 EGF containing fibulin extracellular matrix protein 2 involved_in ISO (MGI:5584046|PMID:23636094) UniProt PMID:23636094 MGI:5584046 NCBI chr 2:6,455,155...6,463,493
Ensembl chr 2:6,450,332...6,463,493
JBrowse link
G ENG endoglin involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
G HES1 hes family bHLH transcription factor 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr13:131,135,970...131,137,865
Ensembl chr13:131,135,724...131,138,236
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:37,219,887...37,231,321
Ensembl chr 1:37,219,883...37,231,385
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chr 6:28,666,458...28,806,432
Ensembl chr 6:28,617,445...28,872,058
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2136698|PMID:11439183) MGI
Ensembl
PMID:11439183 GO_REF:0000107 MGI:2136698 NCBI chr 7:74,918,982...74,929,688
Ensembl chr 7:74,918,982...74,931,348
JBrowse link
G RAMP2 receptor activity modifying protein 2 involved_in ISS
IEA
UniProt
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr12:20,092,204...20,094,426
Ensembl chr12:20,092,193...20,094,474
JBrowse link
G SGCB sarcoglycan beta acts_upstream_of_or_within ISO (MGI:1352919|PMID:10678176) MGI PMID:10678176 MGI:1352919 NCBI chr 8:39,130,371...39,148,756 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17278
    multicellular organismal process 8465
      multicellular organism development 5272
        system development 4784
          vasculature development 846
            vascular associated smooth muscle cell differentiation 48
              aortic smooth muscle cell differentiation + 6
              cardiac vascular smooth muscle cell differentiation + 10
              negative regulation of vascular associated smooth muscle cell differentiation + 13
              positive regulation of vascular associated smooth muscle cell differentiation + 9
              regulation of vascular associated smooth muscle cell differentiation + 22
              vascular associated smooth muscle cell development + 13
              vascular associated smooth muscle cell differentiation involved in phenotypic switching + 4
              vascular associated smooth muscle cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 17278
    developmental process 6628
      anatomical structure development 6181
        multicellular organism development 5272
          system development 4784
            circulatory system development 1301
              vasculature development 846
                vascular associated smooth muscle cell differentiation 48
                  aortic smooth muscle cell differentiation + 6
                  cardiac vascular smooth muscle cell differentiation + 10
                  negative regulation of vascular associated smooth muscle cell differentiation + 13
                  positive regulation of vascular associated smooth muscle cell differentiation + 9
                  regulation of vascular associated smooth muscle cell differentiation + 22
                  vascular associated smooth muscle cell development + 13
                  vascular associated smooth muscle cell differentiation involved in phenotypic switching + 4
                  vascular associated smooth muscle cell fate commitment + 0
paths to the root