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ONTOLOGY REPORT - ANNOTATIONS


Term:vascular associated smooth muscle cell differentiation
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Accession:GO:0035886 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.
Synonyms:exact_synonym: VSMC differentiation;   vascular smooth muscle cell differentiation



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vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,250
JBrowse link
G C3 complement C3 acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G CFD complement factor D acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383 NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884
JBrowse link
G CFH complement factor H acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476
JBrowse link
G EPC1 enhancer of polycomb homolog 1 ISO RGD PMID:22398275 RGD:9587795 NCBI chr10:32,267,751...32,378,769
Ensembl chr10:32,267,751...32,378,798
JBrowse link
G MIR145 microRNA 145 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733
JBrowse link
G MRTFB myocardin related transcription factor B acts_upstream_of_or_within ISO (MGI:3607644|PMID:16204380) MGI PMID:16204380 MGI:3607644 NCBI chr16:13,994,774...14,266,779
Ensembl chr16:14,071,319...14,266,773
JBrowse link
G MYOCD myocardin involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr17:12,665,890...12,768,949
Ensembl chr17:12,665,890...12,768,949
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2136698|PMID:11439183) MGI
Ensembl
PMID:11439183 GO_REF:0000107 MGI:2136698 NCBI chr14:24,366,911...24,379,604
Ensembl chr14:24,365,673...24,379,604
JBrowse link
G PITX2 paired like homeodomain 2 acts_upstream_of_or_within ISO (MGI:3796777|PMID:18458156) MGI PMID:18458156 MGI:3796777 NCBI chr 4:110,617,423...110,642,123
Ensembl chr 4:110,617,423...110,642,123
JBrowse link
G QKI QKI, KH domain containing RNA binding acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3029686|PMID:14706070) MGI
Ensembl
PMID:14706070 GO_REF:0000107 MGI:3029686 NCBI chr 6:163,414,718...163,578,592
Ensembl chr 6:163,414,000...163,578,592
JBrowse link
aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) MGI PMID:19342595 MGI:5007924 NCBI chr 9:2,015,347...2,193,624
Ensembl chr 9:1,980,290...2,193,624
JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) MGI PMID:19342595 MGI:5007924 NCBI chr19:10,961,030...11,062,273
Ensembl chr19:10,960,932...11,079,426
JBrowse link
cardiac vascular smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4838384|PMID:20619341) Ensembl
Ensembl
MGI
PMID:20619341 GO_REF:0000107 MGI:4838384 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G NOTCH1 notch receptor 1 involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G VEGFA vascular endothelial growth factor A involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 involved_in IMP (PMID:11889139), (PMID:12615657) UniProt
UniProt
PMID:11889139 PMID:12615657 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IMP (PMID:18297060) BHF-UCL
BHF-UCL
PMID:18297060 NCBI chr15:89,732,446...89,751,249
Ensembl chr15:89,749,875...89,751,249
JBrowse link
G MIR143 microRNA 143 acts_upstream_of_or_within ISO (MGI:4443305|PMID:19816508) MGI PMID:19816508 MGI:4443305 NCBI chr 5:149,428,918...149,429,023
Ensembl chr 5:149,428,918...149,429,023
JBrowse link
G MIR145 microRNA 145 acts_upstream_of_or_within ISO (MGI:4443305|PMID:19816508) MGI PMID:19816508 MGI:4443305 NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733
JBrowse link
G MYOCD myocardin involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:12,665,890...12,768,949
Ensembl chr17:12,665,890...12,768,949
JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3513738|PMID:15569937) Ensembl
Ensembl
MGI
PMID:15569937 GO_REF:0000107 MGI:3513738 NCBI chr 6:43,171,269...43,181,506
Ensembl chr 6:43,171,269...43,181,506
JBrowse link
negative regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR21 microRNA 21 involved_in IDA (PMID:22034194) BHF-UCL PMID:22034194 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
negative regulation of cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR100 microRNA 100 involved_in IMP (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr11:122,152,229...122,152,308
Ensembl chr11:122,152,229...122,152,308
JBrowse link
G MIR15B microRNA 15b involved_in IMP (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr 3:160,404,588...160,404,685
Ensembl chr 3:160,404,588...160,404,685
JBrowse link
G MIR221 microRNA 221 involved_in IMP (PMID:18548003), (PMID:19088079) BHF-UCL PMID:18548003 PMID:19088079 NCBI chr  X:45,746,157...45,746,266
Ensembl chr  X:45,746,157...45,746,266
JBrowse link
G MIR26A1 microRNA 26a-1 involved_in IDA (PMID:20857419) BHF-UCL PMID:20857419 NCBI chr 3:37,969,404...37,969,480
Ensembl chr 3:37,969,404...37,969,480
JBrowse link
G MIR26A2 microRNA 26a-2 involved_in IDA (PMID:20857419) BHF-UCL PMID:20857419 NCBI chr12:57,824,609...57,824,692
Ensembl chr12:57,824,609...57,824,692
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 involved_in IDA (PMID:23853098) BHF-UCL
BHF-UCL
PMID:23853098 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFATC2 nuclear factor of activated T cells 2 involved_in IDA (PMID:23853098) BHF-UCL
BHF-UCL
PMID:23853098 NCBI chr20:51,386,963...51,562,839
Ensembl chr20:51,386,957...51,562,831
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 involved_in IDA (PMID:23853098) BHF-UCL
BHF-UCL
PMID:23853098 NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259
JBrowse link
G PDCD4 programmed cell death 4 involved_in IDA (PMID:18548003) BHF-UCL
BHF-UCL
PMID:18548003 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in IDA (PMID:19088079) BHF-UCL
BHF-UCL
PMID:19088079 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNMT1 DNA methyltransferase 1 involved_in IMP (PMID:27021683) BHF-UCL
BHF-UCL
PMID:27021683 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
JBrowse link
G FGF9 fibroblast growth factor 9 involved_in ISS BHF-UCL
BHF-UCL
GO_REF:0000024 NCBI chr13:21,671,073...21,704,498
Ensembl chr13:21,671,073...21,704,498
JBrowse link
positive regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTH cystathionine gamma-lyase involved_in IMP (PMID:21659522) BHF-UCL
BHF-UCL
PMID:21659522 NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851
JBrowse link
G EFEMP2 EGF containing fibulin extracellular matrix protein 2 involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr11:65,866,441...65,872,800
Ensembl chr11:65,866,441...65,873,592
JBrowse link
G MIR424 microRNA 424 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr  X:134,546,614...134,546,711
Ensembl chr  X:134,546,614...134,546,711
JBrowse link
positive regulation of cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPER1 G protein-coupled estrogen receptor 1 involved_in IMP (PMID:23840305) AgBase
AgBase
PMID:23840305 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G MIR1-1 microRNA 1-1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr20:62,554,306...62,554,376
Ensembl chr20:62,554,306...62,554,376
JBrowse link
G MIR1-2 microRNA 1-2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr18:21,829,004...21,829,088
Ensembl chr18:21,829,004...21,829,088
JBrowse link
G MIR145 microRNA 145 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733
JBrowse link
G MYOCD myocardin involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr17:12,665,890...12,768,949
Ensembl chr17:12,665,890...12,768,949
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENG endoglin involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in IDA (PMID:19088079) BHF-UCL
BHF-UCL
PMID:19088079 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783
JBrowse link
G MIR125B1 microRNA 125b-1 involved_in IMP (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr11:122,099,757...122,099,844
Ensembl chr11:122,099,757...122,099,844
JBrowse link
G MIR125B2 microRNA 125b-2 involved_in IMP (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr21:16,590,237...16,590,325
Ensembl chr21:16,590,237...16,590,325
JBrowse link
G MIR21 microRNA 21 involved_in IMP (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR140 microRNA 140 involved_in IDA (PMID:27021683) BHF-UCL PMID:27021683 NCBI chr16:69,933,081...69,933,180
Ensembl chr16:69,933,081...69,933,180
JBrowse link
G MIR18A microRNA 18a involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr13:91,350,751...91,350,821
Ensembl chr13:91,350,751...91,350,821
JBrowse link
G SOD2 superoxide dismutase 2 involved_in IDA (PMID:27021683) BHF-UCL
BHF-UCL
PMID:27021683 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SDC4 syndecan 4 NOT|involved_in ISO PMID:25089138 BHF-UCL PMID:25089138 RGD:11079193 NCBI chr20:45,325,288...45,348,424
Ensembl chr20:45,325,288...45,348,424
JBrowse link
vascular associated smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G COMP cartilage oligomeric matrix protein involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5318950|PMID:21350216) Ensembl
Ensembl
MGI
PMID:21350216 GO_REF:0000107 MGI:5318950 NCBI chr19:18,782,773...18,791,305
Ensembl chr19:18,782,773...18,791,305
JBrowse link
G EDNRA endothelin receptor type A involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
JBrowse link
G EFEMP2 EGF containing fibulin extracellular matrix protein 2 involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr11:65,866,441...65,872,800
Ensembl chr11:65,866,441...65,873,592
JBrowse link
G ENG endoglin involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 9:127,815,012...127,854,773
Ensembl chr 9:127,815,013...127,854,658
JBrowse link
G HES1 hes family bHLH transcription factor 1 involved_in ISS
IEA
BHF-UCL
Ensembl
BHF-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in IEP (PMID:15821257) UniProt
UniProt
PMID:15821257 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G NFATC3 nuclear factor of activated T cells 3 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259
JBrowse link
G NFATC4 nuclear factor of activated T cells 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2136698|PMID:11439183) MGI
Ensembl
PMID:11439183 GO_REF:0000107 MGI:2136698 NCBI chr14:24,366,911...24,379,604
Ensembl chr14:24,365,673...24,379,604
JBrowse link
G RAMP2 receptor activity modifying protein 2 involved_in ISS
IEA
UniProt
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr17:42,761,227...42,763,041
Ensembl chr17:42,758,447...42,763,041
JBrowse link
G SGCB sarcoglycan beta involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1352919|PMID:10678176) Ensembl
Ensembl
MGI
PMID:10678176 GO_REF:0000107 MGI:1352919 NCBI chr 4:52,020,706...52,038,299
Ensembl chr 4:52,020,706...52,038,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19643
    multicellular organismal process 8658
      multicellular organism development 5802
        system development 5303
          vasculature development 941
            vascular associated smooth muscle cell differentiation 53
              aortic smooth muscle cell differentiation + 7
              cardiac vascular smooth muscle cell differentiation + 12
              negative regulation of vascular associated smooth muscle cell differentiation + 14
              positive regulation of vascular associated smooth muscle cell differentiation + 16
              regulation of vascular associated smooth muscle cell differentiation + 30
              vascular associated smooth muscle cell development + 13
              vascular associated smooth muscle cell differentiation involved in phenotypic switching + 5
              vascular associated smooth muscle cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 19643
    developmental process 7530
      anatomical structure development 6889
        multicellular organism development 5802
          system development 5303
            circulatory system development 1434
              vasculature development 941
                vascular associated smooth muscle cell differentiation 53
                  aortic smooth muscle cell differentiation + 7
                  cardiac vascular smooth muscle cell differentiation + 12
                  negative regulation of vascular associated smooth muscle cell differentiation + 14
                  positive regulation of vascular associated smooth muscle cell differentiation + 16
                  regulation of vascular associated smooth muscle cell differentiation + 30
                  vascular associated smooth muscle cell development + 13
                  vascular associated smooth muscle cell differentiation involved in phenotypic switching + 5
                  vascular associated smooth muscle cell fate commitment + 0
paths to the root