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ONTOLOGY REPORT - ANNOTATIONS

Term:vascular associated smooth muscle cell differentiation
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Accession:GO:0035886 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.
Synonyms:exact_synonym: VSMC differentiation;   vascular smooth muscle cell differentiation

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vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO (MGI:5584055|PMID:23603510) BHF-UCL PMID:23603510 MGI:5584055 NCBI chrNW_004955511:2,321,445...2,324,417
Ensembl chrNW_004955511:2,322,920...2,324,068 		JBrowse link
G C3 complement C3 acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G Cfd complement factor D acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) MGI PMID:28057640 MGI:5883383 NCBI chrNW_004955495:6,955,612...6,961,317 JBrowse link
G Epc1 enhancer of polycomb homolog 1 ISO RGD PMID:22398275 RGD:9587795 NCBI chrNW_004955429:23,819,261...23,910,279
Ensembl chrNW_004955429:23,817,254...23,909,946 		JBrowse link
G Mrtfb myocardin related transcription factor B acts_upstream_of_or_within ISO (MGI:3607644|PMID:16204380) MGI PMID:16204380 MGI:3607644 NCBI chrNW_004955442:4,542,700...4,733,646
Ensembl chrNW_004955442:4,547,829...4,733,724 		JBrowse link
G Myocd myocardin involved_in ISO (MGI:4354665|PMID:19578358) BHF-UCL PMID:19578358 MGI:4354665 NCBI chrNW_004955467:4,653,065...4,743,438
Ensembl chrNW_004955467:4,656,380...4,743,110 		JBrowse link
G Nfatc3 nuclear factor of activated T cells 3 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chrNW_004955484:8,433,765...8,558,005
Ensembl chrNW_004955484:8,436,330...8,526,680 		JBrowse link
G Nfatc4 nuclear factor of activated T cells 4 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chrNW_004955409:35,931,208...35,941,555
Ensembl chrNW_004955409:35,931,173...35,940,696 		JBrowse link
G Pitx2 paired like homeodomain 2 acts_upstream_of_or_within ISO (MGI:3796777|PMID:18458156) MGI PMID:18458156 MGI:3796777 NCBI chrNW_004955457:15,803,493...15,823,193
Ensembl chrNW_004955457:15,803,219...15,823,310 		JBrowse link
G Qki QKI, KH domain containing RNA binding acts_upstream_of_or_within ISO (MGI:3029686|PMID:14706070) MGI PMID:14706070 MGI:3029686 NCBI chrNW_004955439:17,925,205...18,079,727
Ensembl chrNW_004955439:17,925,229...18,079,727 		JBrowse link
aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) MGI PMID:19342595 MGI:5007924 NCBI chrNW_004955434:6,420,850...6,592,797
Ensembl chrNW_004955434:6,420,854...6,594,425 		JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) MGI PMID:19342595 MGI:5007924 NCBI chrNW_004955495:2,021,671...2,105,155
Ensembl chrNW_004955495:2,021,566...2,105,397 		JBrowse link
cardiac vascular smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO (MGI:4838384|PMID:20619341) MGI PMID:20619341 MGI:4838384 NCBI chrNW_004955436:7,060,930...7,070,610
Ensembl chrNW_004955436:7,060,930...7,070,030 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:5298073|PMID:21311046) BHF-UCL PMID:21311046 MGI:5298073 NCBI chrNW_004955513:4,225,939...4,264,875
Ensembl chrNW_004955513:4,225,956...4,263,259 		JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (MGI:4461879|PMID:18093989) BHF-UCL PMID:18093989 MGI:4461879 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myocd myocardin involved_in ISO PMID:16151017 BHF-UCL PMID:16151017 RGD:8554320 NCBI chrNW_004955467:4,653,065...4,743,438
Ensembl chrNW_004955467:4,656,380...4,743,110 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO (MGI:3513738|PMID:15569937) MGI PMID:15569937 MGI:3513738 NCBI chrNW_004955437:9,100,546...9,109,305
Ensembl chrNW_004955437:9,098,968...9,107,057 		JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfatc1 nuclear factor of activated T cells 1 involved_in ISO (PMID:23853098) BHF-UCL PMID:23853098 NCBI chrNW_004955402:62,558,392...62,674,347
Ensembl chrNW_004955402:62,558,286...62,674,457 		JBrowse link
G Nfatc2 nuclear factor of activated T cells 2 involved_in ISO (PMID:23853098) BHF-UCL PMID:23853098 NCBI chrNW_004955445:7,035,876...7,153,199
Ensembl chrNW_004955445:7,035,876...7,153,237 		JBrowse link
G Nfatc3 nuclear factor of activated T cells 3 involved_in ISO (PMID:23853098) BHF-UCL PMID:23853098 NCBI chrNW_004955484:8,433,765...8,558,005
Ensembl chrNW_004955484:8,436,330...8,526,680 		JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chrNW_004955485:530,642...553,508
Ensembl chrNW_004955485:529,860...553,601 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO (PMID:19088079) BHF-UCL PMID:19088079 NCBI chrNW_004955413:25,150,702...25,166,987
Ensembl chrNW_004955413:25,148,062...25,166,987 		JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 involved_in ISO (PMID:27021683) BHF-UCL PMID:27021683 NCBI chrNW_004955495:1,465,529...1,505,379
Ensembl chrNW_004955495:1,465,480...1,505,462 		JBrowse link
G Fgf9 fibroblast growth factor 9 involved_in ISO PMID:28259995 BHF-UCL PMID:28259995 RGD:13601993 NCBI chrNW_004955497:2,199,424...2,232,088
Ensembl chrNW_004955497:2,199,409...2,235,893 		JBrowse link
positive regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cth cystathionine gamma-lyase involved_in ISO (PMID:21659522) BHF-UCL PMID:21659522 NCBI chrNW_004955423:21,542,587...21,567,935
Ensembl chrNW_004955423:21,542,179...21,567,786 		JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 involved_in ISO (MGI:4947512|PMID:20019329) UniProt PMID:20019329 MGI:4947512 NCBI chrNW_004955422:19,463,090...19,470,605
Ensembl chrNW_004955422:19,463,987...19,470,605 		JBrowse link
positive regulation of cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO (PMID:23840305) AgBase PMID:23840305 NCBI chrNW_004955460:8,790,798...8,794,902
Ensembl chrNW_004955460:8,790,798...8,794,902 		JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eng endoglin involved_in ISO (MGI:3721185|PMID:17628518) BHF-UCL PMID:17628518 MGI:3721185 NCBI chrNW_004955419:818,797...853,319
Ensembl chrNW_004955419:818,932...852,694 		JBrowse link
G Kit KIT proto-oncogene, receptor tyrosine kinase involved_in ISO (PMID:19088079) BHF-UCL PMID:19088079 NCBI chrNW_004955447:16,149,014...16,226,151
Ensembl chrNW_004955447:16,148,605...16,226,734 		JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sod2 superoxide dismutase 2 involved_in ISO (PMID:27021683) BHF-UCL PMID:27021683 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163 		JBrowse link
regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sdc4 syndecan 4 NOT|involved_in ISO PMID:25089138 BHF-UCL PMID:25089138 RGD:11079193 NCBI chrNW_004955445:11,990,916...12,009,178
Ensembl chrNW_004955445:11,990,792...12,011,553 		JBrowse link
vascular associated smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (MGI:3772552|PMID:18097473) UniProt PMID:18097473 MGI:3772552 NCBI chrNW_004955414:25,951,473...25,953,593
Ensembl chrNW_004955414:25,951,349...25,953,645 		JBrowse link
G Ednra endothelin receptor type A involved_in ISO (MGI:5585582|PMID:24412386) MGI PMID:24412386 MGI:5585582 NCBI chrNW_004955428:3,062,303...3,114,761
Ensembl chrNW_004955428:3,062,303...3,114,761 		JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 involved_in ISO (MGI:5584046|PMID:23636094) UniProt PMID:23636094 MGI:5584046 NCBI chrNW_004955422:19,463,090...19,470,605
Ensembl chrNW_004955422:19,463,987...19,470,605 		JBrowse link
G Eng endoglin involved_in ISO (MGI:3721185|PMID:17628518) BHF-UCL PMID:17628518 MGI:3721185 NCBI chrNW_004955419:818,797...853,319
Ensembl chrNW_004955419:818,932...852,694 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in ISO (MGI:4453944|PMID:20122914) BHF-UCL PMID:20122914 MGI:4453944 NCBI chrNW_004955420:14,565,921...14,568,447
Ensembl chrNW_004955420:14,564,283...14,568,447 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 involved_in ISO (PMID:15821257) UniProt PMID:15821257 NCBI chrNW_004955436:7,060,930...7,070,610
Ensembl chrNW_004955436:7,060,930...7,070,030 		JBrowse link
G Nfatc3 nuclear factor of activated T cells 3 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chrNW_004955484:8,433,765...8,558,005
Ensembl chrNW_004955484:8,436,330...8,526,680 		JBrowse link
G Nfatc4 nuclear factor of activated T cells 4 acts_upstream_of_or_within ISO (MGI:2136698|PMID:11439183) MGI PMID:11439183 MGI:2136698 NCBI chrNW_004955409:35,931,208...35,941,555
Ensembl chrNW_004955409:35,931,173...35,940,696 		JBrowse link
G Ramp2 receptor activity modifying protein 2 involved_in ISO (MGI:3772552|PMID:18097473) UniProt PMID:18097473 MGI:3772552 NCBI chrNW_004955451:16,584,742...16,586,093 JBrowse link
G Sgcb sarcoglycan beta acts_upstream_of_or_within ISO (MGI:1352919|PMID:10678176) MGI PMID:10678176 MGI:1352919 NCBI chrNW_004955447:18,459,562...18,472,367
Ensembl chrNW_004955447:18,459,562...18,469,324 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12199
    multicellular organismal process 6266
      multicellular organism development 4697
        system development 4265
          vasculature development 704
            vascular associated smooth muscle cell differentiation 34
              aortic smooth muscle cell differentiation + 5
              cardiac vascular smooth muscle cell differentiation + 6
              negative regulation of vascular associated smooth muscle cell differentiation + 7
              positive regulation of vascular associated smooth muscle cell differentiation + 6
              regulation of vascular associated smooth muscle cell differentiation + 14
              vascular associated smooth muscle cell development + 12
              vascular associated smooth muscle cell differentiation involved in phenotypic switching + 3
              vascular associated smooth muscle cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 12199
    developmental process 5778
      anatomical structure development 5431
        multicellular organism development 4697
          system development 4265
            circulatory system development 1121
              vasculature development 704
                vascular associated smooth muscle cell differentiation 34
                  aortic smooth muscle cell differentiation + 5
                  cardiac vascular smooth muscle cell differentiation + 6
                  negative regulation of vascular associated smooth muscle cell differentiation + 7
                  positive regulation of vascular associated smooth muscle cell differentiation + 6
                  regulation of vascular associated smooth muscle cell differentiation + 14
                  vascular associated smooth muscle cell development + 12
                  vascular associated smooth muscle cell differentiation involved in phenotypic switching + 3
                  vascular associated smooth muscle cell fate commitment + 0
paths to the root