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ONTOLOGY REPORT - ANNOTATIONS


Term:vascular associated smooth muscle cell differentiation
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Accession:GO:0035886 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.
Synonyms:exact_synonym: VSMC differentiation;   vascular smooth muscle cell differentiation



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vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO (MGI:5584055|PMID:23603510) RGD PMID:23603510 MGI:5584055 NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
JBrowse link
G C3 complement C3 acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) RGD PMID:28057640 MGI:5883383 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cfd complement factor D acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) RGD PMID:28057640 MGI:5883383 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) RGD PMID:28057640 MGI:5883383 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Epc1 enhancer of polycomb homolog 1 IEP RGD PMID:22398275 RGD:9587795 NCBI chr17:54,503,358...54,594,444
Ensembl chr17:54,503,358...54,594,425
JBrowse link
G Mrtfb myocardin related transcription factor B acts_upstream_of_or_within ISO MGI:3608959 (MGI:3607644|PMID:16204380) RGD PMID:16204380 MGI:3607644 NCBI chr10:1,116,315...1,278,106
Ensembl chr10:1,116,310...1,277,897
JBrowse link
G Myocd myocardin involved_in IEA
ISO
GO_REF:0000107
RNAcentral:URS0000527F89_10090 (MGI:4354665|PMID:19578358)
Ensembl
RGD
PMID:19578358 GO_REF:0000107 MGI:4354665 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:1920431 (MGI:2136698|PMID:11439183) RGD PMID:11439183 MGI:2136698 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 acts_upstream_of_or_within ISO MGI:103296 (MGI:2136698|PMID:11439183) RGD PMID:11439183 MGI:2136698 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
JBrowse link
G Pitx2 paired-like homeodomain 2 acts_upstream_of_or_within ISO MGI:2136268 (MGI:3796777|PMID:18458156) RGD PMID:18458156 MGI:3796777 NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293
JBrowse link
G Qki QKI, KH domain containing RNA binding acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:3033861 (MGI:3029686|PMID:14706070)
GO_REF:0000107
RGD
Ensembl
PMID:14706070 GO_REF:0000107 MGI:3029686 NCBI chr 1:50,387,698...50,501,568
Ensembl chr 1:50,387,698...50,498,831
JBrowse link
aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) RGD PMID:19342595 MGI:5007924 NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684
JBrowse link
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 acts_upstream_of_or_within ISO (MGI:5007924|PMID:19342595) RGD PMID:19342595 MGI:5007924 NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975
JBrowse link
cardiac vascular smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO MGI:2447620 (MGI:4838384|PMID:20619341) RGD PMID:20619341 MGI:4838384 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:5298073|PMID:21311046) RGD PMID:21311046 MGI:5298073 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (MGI:4461879|PMID:18093989) RGD PMID:18093989 MGI:4461879 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in IEA
ISO
GO_REF:0000107
(PMID:11889139), (PMID:12615657)
Ensembl
RGD
PMID:11889139 PMID:12615657 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18297060) RGD PMID:18297060 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
G Mir143 microRNA 143 acts_upstream_of_or_within ISO MGI:2676830 (MGI:4443305|PMID:19816508) RGD PMID:19816508 MGI:4443305 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110
JBrowse link
G Mir145 microRNA 145 acts_upstream_of_or_within ISO MGI:2676828 (MGI:4443305|PMID:19816508) RGD PMID:19816508 MGI:4443305 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Myocd myocardin involved_in IDA PMID:16151017 BHF-UCL PMID:16151017 RGD:8554320 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO MGI:3522206|MGI:3522214 (MGI:3513738|PMID:15569937) RGD PMID:15569937 MGI:3513738 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
negative regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir21 microRNA 21 involved_in ISO (PMID:22034194) RGD PMID:22034194 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir100 microRNA 100 involved_in ISO (PMID:18548003) RGD PMID:18548003 NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304
JBrowse link
G Mir15b microRNA 15b involved_in ISO (PMID:18548003) RGD PMID:18548003 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:18548003), (PMID:19088079) RGD PMID:18548003 PMID:19088079 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Mir26a microRNA 26a involved_in ISO (PMID:20857419) RGD PMID:20857419 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 involved_in ISO (PMID:23853098) RGD PMID:23853098 NCBI chr18:74,046,421...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 involved_in ISO (PMID:23853098) RGD PMID:23853098 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 involved_in ISO (PMID:23853098) RGD PMID:23853098 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISO (PMID:18548003) RGD PMID:18548003 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in IEA
ISO
GO_REF:0000107
(PMID:19088079)
Ensembl
RGD
PMID:19088079 GO_REF:0000107 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 involved_in ISO
IEA
(PMID:27021683)
GO_REF:0000107
RGD
Ensembl
PMID:27021683 GO_REF:0000107 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Fgf9 fibroblast growth factor 9 involved_in IMP PMID:28259995 BHF-UCL PMID:28259995 RGD:13601993 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
positive regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cth cystathionine gamma-lyase involved_in ISO
IEA
(PMID:21659522)
GO_REF:0000107
RGD
Ensembl
PMID:21659522 GO_REF:0000107 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 involved_in ISO (MGI:4947512|PMID:20019329) RGD PMID:20019329 MGI:4947512 NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414
JBrowse link
positive regulation of cardiac vascular smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO
IEA
(PMID:23840305)
GO_REF:0000107
RGD
Ensembl
PMID:23840305 GO_REF:0000107 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eng endoglin involved_in ISO (MGI:3721185|PMID:17628518) RGD PMID:17628518 MGI:3721185 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in ISO (PMID:19088079) RGD PMID:19088079 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:18548003) RGD PMID:18548003 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052
JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:18548003) RGD PMID:18548003 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:18548003) RGD PMID:18548003 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir140 microRNA 140 involved_in ISO (PMID:27021683) RGD PMID:27021683 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
JBrowse link
G Mir145 microRNA 145 IMP RGD PMID:19542014 RGD:13210556 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727
JBrowse link
G Sod2 superoxide dismutase 2 involved_in ISO (PMID:27021683) RGD PMID:27021683 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
regulation of aortic smooth muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sdc4 syndecan 4 NOT|involved_in IDA PMID:25089138 BHF-UCL PMID:25089138 RGD:11079193 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
vascular associated smooth muscle cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (MGI:3772552|PMID:18097473) RGD PMID:18097473 MGI:3772552 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Comp cartilage oligomeric matrix protein involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5318950|PMID:21350216)
Ensembl
RGD
PMID:21350216 GO_REF:0000107 MGI:5318950 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
JBrowse link
G Ednra endothelin receptor type A involved_in ISO MGI:2687362 (MGI:5585582|PMID:24412386) RGD PMID:24412386 MGI:5585582 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 involved_in ISO (MGI:5584046|PMID:23636094) RGD PMID:23636094 MGI:5584046 NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414
JBrowse link
G Eng endoglin involved_in ISO (MGI:3721185|PMID:17628518) RGD PMID:17628518 MGI:3721185 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:4453944|PMID:20122914)
Ensembl
RGD
PMID:20122914 GO_REF:0000107 MGI:4453944 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 involved_in ISO (PMID:15821257) RGD PMID:15821257 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 acts_upstream_of_or_within ISO MGI:1920431 (MGI:2136698|PMID:11439183) RGD PMID:11439183 MGI:2136698 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 acts_upstream_of_or_within ISO MGI:103296 (MGI:2136698|PMID:11439183) RGD PMID:11439183 MGI:2136698 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
JBrowse link
G Ramp2 receptor activity modifying protein 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3772552|PMID:18097473)
UniProt
RGD
PMID:18097473 GO_REF:0000024 MGI:3772552 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Sgcb sarcoglycan, beta acts_upstream_of_or_within ISO MGI:2153048 (MGI:1352919|PMID:10678176) RGD PMID:10678176 MGI:1352919 NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19874
    multicellular organismal process 9240
      multicellular organism development 5236
        system development 4498
          vasculature development 863
            vascular associated smooth muscle cell differentiation 48
              aortic smooth muscle cell differentiation + 6
              cardiac vascular smooth muscle cell differentiation + 10
              negative regulation of vascular associated smooth muscle cell differentiation + 12
              positive regulation of vascular associated smooth muscle cell differentiation + 11
              regulation of vascular associated smooth muscle cell differentiation + 23
              vascular associated smooth muscle cell development + 13
              vascular associated smooth muscle cell differentiation involved in phenotypic switching + 5
              vascular associated smooth muscle cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 19874
    developmental process 7013
      anatomical structure development 6447
        multicellular organism development 5236
          system development 4498
            circulatory system development 1334
              vasculature development 863
                vascular associated smooth muscle cell differentiation 48
                  aortic smooth muscle cell differentiation + 6
                  cardiac vascular smooth muscle cell differentiation + 10
                  negative regulation of vascular associated smooth muscle cell differentiation + 12
                  positive regulation of vascular associated smooth muscle cell differentiation + 11
                  regulation of vascular associated smooth muscle cell differentiation + 23
                  vascular associated smooth muscle cell development + 13
                  vascular associated smooth muscle cell differentiation involved in phenotypic switching + 5
                  vascular associated smooth muscle cell fate commitment + 0
paths to the root