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ONTOLOGY REPORT - ANNOTATIONS


Term:enteroendocrine cell differentiation
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Accession:GO:0035883 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.



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enteroendocrine cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:1096974|PMID:9308961)
UniProt
RGD
PMID:9308961 GO_REF:0000024 MGI:1096974 NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649
JBrowse link
G Nkx6-3 NK6 homeobox 3 acts_upstream_of
acts_upstream_of_or_within
ISO MGI:3795186 (PMID:18347062) RGD PMID:18347062 NCBI chr16:68,868,404...68,873,617
Ensembl chr16:68,868,404...68,873,617
JBrowse link
G Onecut1 one cut homeobox 1 acts_upstream_of_or_within ISO MGI:2179340 (PMID:10825208) RGD PMID:10825208 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 acts_upstream_of_or_within ISO MGI:2181362 (PMID:16418487) RGD PMID:16418487 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Percc1 proline and glutamate rich with coiled coil 1 involved_in ISO (MGI:6368375|PMID:31217582) RGD PMID:31217582 MGI:6368375 NCBI chr10:14,187,858...14,190,634
Ensembl chr10:14,188,216...14,189,040
Ensembl chr10:14,188,216...14,189,040
JBrowse link
G Rbm4 RNA binding motif protein 4 acts_upstream_of_or_within ISO MGI:5467987|MGI:5467988 (PMID:23129807) RGD PMID:23129807 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380
JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2149672 (PMID:10615124)
Ensembl
RGD
PMID:10615124 GO_REF:0000107 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Mir7-1 microRNA 7-1 acts_upstream_of_or_within ISO (PMID:22764048) RGD PMID:22764048 NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360
JBrowse link
negative regulation of stomach neuroendocrine cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2149672 (PMID:18173746)
Ensembl
RGD
PMID:18173746 GO_REF:0000107 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
negative regulation of type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator IMP RGD PMID:23178930 RGD:11567224 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
pancreatic A cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax6 paired box 6 involved_in IMP
IEA
ISO
PMID:20592023
GO_REF:0000107
(MGI:4943812|PMID:20592023)
(PMID:20592023)
Ensembl
RGD
PMID:20592023 PMID:20592023 GO_REF:0000107 MGI:4943812, RGD:8552352 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
pancreatic A cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:16887115)
Ensembl
RGD
PMID:16887115 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
MGI:2149672 (PMID:10615124)
Ensembl
RGD
PMID:10615124 GO_REF:0000107 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in
acts_upstream_of_or_within
ISO (MGI:3619850|PMID:16511571)
(PMID:16511571)
RGD PMID:16511571 MGI:3619850 NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003
JBrowse link
G Nkx6-1 NK6 homeobox 1 acts_upstream_of_or_within ISO MGI:1352738 (PMID:15944193) RGD PMID:15944193 NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681
JBrowse link
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO MGI:1206039 (PMID:15944193) RGD PMID:15944193 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515
JBrowse link
G Onecut1 one cut homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2179340 (PMID:10825208)
Ensembl
RGD
PMID:10825208 GO_REF:0000107 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
JBrowse link
G Pax6 paired box 6 IMP RGD PMID:20592023 RGD:8552352 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Rfx6 regulatory factor X, 6 involved_in ISO (MGI:4422104|PMID:20148032) RGD PMID:20148032 MGI:4422104 NCBI chr20:31,019,784...31,073,266
Ensembl chr20:31,019,829...31,073,147
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (PMID:25186293) RGD PMID:25186293 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 acts_upstream_of_or_within ISO MGI:97347 (PMID:17988662) RGD PMID:17988662 NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649
JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1339708|MGI:1932100 (PMID:17202186), (PMID:17988662) RGD PMID:17202186 PMID:17988662 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411
JBrowse link
pancreatic D cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Onecut1 one cut homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2179340 (PMID:10825208)
Ensembl
RGD
PMID:10825208 GO_REF:0000107 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
JBrowse link
G Rfx6 regulatory factor X, 6 involved_in ISO (MGI:4422104|PMID:20148032) RGD PMID:20148032 MGI:4422104 NCBI chr20:31,019,784...31,073,266
Ensembl chr20:31,019,829...31,073,147
JBrowse link
pancreatic epsilon cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfx6 regulatory factor X, 6 involved_in ISO (MGI:4422104|PMID:20148032) RGD PMID:20148032 MGI:4422104 NCBI chr20:31,019,784...31,073,266
Ensembl chr20:31,019,829...31,073,147
JBrowse link
pancreatic PP cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 acts_upstream_of_or_within ISO MGI:97347 (PMID:17988662) RGD PMID:17988662 NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649
JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1339708 (PMID:17988662) RGD PMID:17988662 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411
JBrowse link
positive regulation of type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:3778846|PMID:18223655)
UniProt
Ensembl
RGD
PMID:18223655 GO_REF:0000024 GO_REF:0000107 MGI:3778846 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Rfx3 regulatory factor X3 involved_in ISO (MGI:4941444|PMID:20413507) RGD PMID:20413507 MGI:4941444 NCBI chr 1:225,449,872...225,709,622
Ensembl chr 1:225,456,187...225,709,402
JBrowse link
regulation of type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4819446|PMID:20562852)
UniProt
RGD
PMID:20562852 GO_REF:0000024 MGI:4819446 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Clock clock circadian regulator involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:4819446|PMID:20562852)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:20562852 GO_REF:0000024 GO_REF:0000107 MGI:4819446 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Rheb Ras homolog, mTORC1 binding involved_in ISO
IEA
(PMID:19258434)
GO_REF:0000107
RGD
Ensembl
PMID:19258434 GO_REF:0000107 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
stomach neuroendocrine cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:1857470 (PMID:18173746) RGD PMID:18173746 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
MGI:2149672 (PMID:18173746)
Ensembl
RGD
PMID:18173746 GO_REF:0000107 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
type B pancreatic cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO
ISS
IEA
(PMID:11865031)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11865031 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:11865031) RGD PMID:11865031 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925
JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:11865031) RGD PMID:11865031 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Cdh2 cadherin 2 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6216737|PMID:26750727)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:26750727 GO_REF:0000024 GO_REF:0000107 MGI:6216737 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk6 cyclin-dependent kinase 6 involved_in ISO (PMID:20668294) RGD PMID:20668294 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5426345|PMID:22529374)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22529374 GO_REF:0000024 GO_REF:0000107 MGI:5426345 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Insm1 INSM transcriptional repressor 1 acts_upstream_of_or_within ISO MGI:3656035 (PMID:16951258) RGD PMID:16951258 NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003
JBrowse link
G Mir214 microRNA 214 acts_upstream_of_or_within ISO (PMID:17804764) RGD PMID:17804764 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
JBrowse link
G Mir375 microRNA 375 acts_upstream_of_or_within ISO (PMID:17804764) RGD PMID:17804764 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir503 microRNA 503 acts_upstream_of_or_within ISO (PMID:17804764) RGD PMID:17804764 NCBI chr  X:132,806,303...132,806,373
Ensembl chr  X:132,806,303...132,806,373
JBrowse link
G Mir541 microRNA 541 acts_upstream_of_or_within ISO (PMID:17804764) RGD PMID:17804764 NCBI chr 6:128,757,016...128,757,105
Ensembl chr 6:128,757,016...128,757,105
JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1932100 (PMID:17202186), (PMID:17456846) RGD PMID:17202186 PMID:17456846 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411
JBrowse link
G Nkx6-1 NK6 homeobox 1 IEP RGD PMID:9603781 RGD:2326025 NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO
IEA
(MGI:4365695|PMID:19635472)
GO_REF:0000107
RGD
Ensembl
PMID:19635472 GO_REF:0000107 MGI:4365695 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Sidt2 SID1 transmembrane family, member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5532825 (PMID:23776622)
Ensembl
RGD
PMID:23776622 GO_REF:0000107 NCBI chr 8:46,232,379...46,248,913
Ensembl chr 8:46,232,383...46,248,700
JBrowse link
G Smo smoothened, frizzled class receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2176256|MGI:2684317 (PMID:20185815)
Ensembl
RGD
PMID:20185815 GO_REF:0000107 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (PMID:16246260)
Ensembl
RGD
PMID:16246260 GO_REF:0000107 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
JBrowse link
type B pancreatic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:16887115)
Ensembl
RGD
PMID:16887115 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in
acts_upstream_of_or_within
ISO (MGI:3619850|PMID:16511571)
(PMID:16511571)
RGD PMID:16511571 MGI:3619850 NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003
JBrowse link
G Men1 menin 1 IMP RGD PMID:24157940 RGD:9589069 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871
JBrowse link
G Mir7-1 microRNA 7-1 acts_upstream_of_or_within ISO (PMID:22764048) RGD PMID:22764048 NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360
JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of ISO MGI:1932100 (PMID:14729487) RGD PMID:14729487 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411
JBrowse link
G Nkx6-1 NK6 homeobox 1 acts_upstream_of_or_within ISO MGI:2386119 (PMID:15944193) RGD PMID:15944193 NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681
JBrowse link
G Onecut1 one cut homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2179340 (PMID:10825208)
Ensembl
RGD
PMID:10825208 GO_REF:0000107 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
JBrowse link
G Pax4 paired box 4 acts_upstream_of ISO MGI:2182122 (PMID:14729487) RGD PMID:14729487 NCBI chr 4:57,058,453...57,065,995
Ensembl chr 4:57,058,462...57,063,408
JBrowse link
G Pax6 paired box 6 acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
MGI:1934347 (PMID:22764048)
GO_REF:0000107
RGD
Ensembl
PMID:22764048 PMID:22403172 GO_REF:0000107, RGD:8552355 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 involved_in
acts_upstream_of_or_within
IMP
ISO
IBA
PMID:21108535
MGI:2181362 (PMID:16418487)
GO_REF:0000033
(PMID:12124776), (PMID:24567802)
RGD
GO_Central
PMID:12124776 PMID:16418487 PMID:24567802 PMID:21108535 GO_REF:0000033, RGD:8553608 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Reg1a regenerating family member 1 alpha involved_in ISO MGI:2446480 (PMID:16405968) RGD PMID:16405968 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570
JBrowse link
G Rfx6 regulatory factor X, 6 involved_in ISO (MGI:4422104|PMID:20148032) RGD PMID:20148032 MGI:4422104 NCBI chr20:31,019,784...31,073,266
Ensembl chr20:31,019,829...31,073,147
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (PMID:25186293) RGD PMID:25186293 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
type B pancreatic cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1932100 (PMID:17202186), (PMID:17988662) RGD PMID:17202186 PMID:17988662 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411
JBrowse link
type B pancreatic cell maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhlha15 basic helix-loop-helix family, member a15 acts_upstream_of_or_within ISO MGI:2182768 (PMID:16423820) RGD PMID:16423820 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
JBrowse link
G Gdf11 growth differentiation factor 11 acts_upstream_of_or_within ISO MGI:2449672 (PMID:15548585) RGD PMID:15548585 NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725
JBrowse link
G Rfx3 regulatory factor X3 involved_in ISO (MGI:4941444|PMID:20413507) RGD PMID:20413507 MGI:4941444 NCBI chr 1:225,449,872...225,709,622
Ensembl chr 1:225,456,187...225,709,402
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    cellular process 18312
      cellular developmental process 4721
        cell differentiation 4720
          epithelial cell differentiation 851
            columnar/cuboidal epithelial cell differentiation 154
              glandular epithelial cell differentiation 83
                enteroendocrine cell differentiation 42
                  pancreatic A cell differentiation + 12
                  pancreatic D cell differentiation + 2
                  pancreatic PP cell differentiation + 2
                  pancreatic epsilon cell differentiation + 1
                  stomach neuroendocrine cell differentiation + 2
                  type B pancreatic cell differentiation + 35
Path 2
Term Annotations click to browse term
  biological_process 19872
    developmental process 6994
      anatomical structure development 6515
        tissue development 2298
          epithelium development 1435
            epithelial cell differentiation 851
              columnar/cuboidal epithelial cell differentiation 154
                glandular epithelial cell differentiation 83
                  enteroendocrine cell differentiation 42
                    pancreatic A cell differentiation + 12
                    pancreatic D cell differentiation + 2
                    pancreatic PP cell differentiation + 2
                    pancreatic epsilon cell differentiation + 1
                    stomach neuroendocrine cell differentiation + 2
                    type B pancreatic cell differentiation + 35
paths to the root