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ONTOLOGY REPORT - ANNOTATIONS


Term:site of double-strand break
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Accession:GO:0035861 term browser browse the term
Definition:A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
Synonyms:exact_synonym: site of DSB
 related_synonym: DNA damage foci;   DNA damage focus;   IRIF;   ionizing radiation-induced foci


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site of double-strand break term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07031480.1 RGD:1600115
G Actr2 actin related protein 2 JBrowse link 14 104,338,486 104,375,840 RGD:1600115
RGD:1624291
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:1600115
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:1624291
RGD:13792537
G Arpc1a actin related protein 2/3 complex, subunit 1A JBrowse link 12 11,272,609 11,294,084 RGD:1600115
G Arpc2 actin related protein 2/3 complex, subunit 2 JBrowse link 9 81,518,163 81,548,871 RGD:1600115
G Arpc5 actin related protein 2/3 complex, subunit 5 JBrowse link 13 70,174,970 70,183,879 RGD:1600115
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:1624291
RGD:1600115
G Cgas cyclic GMP-AMP synthase JBrowse link 8 85,789,515 85,804,008 RGD:1624291
RGD:13792537
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 JBrowse link 15 42,500,929 42,519,019 RGD:1624291
RGD:1600115
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:1624291
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:1624291
RGD:1600115
G Helb DNA helicase B JBrowse link 7 64,860,641 64,888,146 RGD:1624291
RGD:1600115
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:13792537
G Kdm4d lysine demethylase 4D JBrowse link 8 12,968,192 12,993,651 RGD:1624291
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1600115
RGD:13792537
RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1600115
RGD:1624291
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:1600115
RGD:1624291
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 8 115,173,440 115,179,543 RGD:1624291
RGD:13792537
G Paxx PAXX, non-homologous end joining factor JBrowse link 3 2,678,987 2,681,668 RGD:1624291
RGD:13792537
G Phf1 PHD finger protein 1 JBrowse link 20 5,526,926 5,531,940 RGD:1624291
RGD:1600115
G Polh DNA polymerase eta JBrowse link 9 17,163,354 17,198,006 RGD:13792537
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:1624291
RGD:1600115
G Rad18 RAD18 E3 ubiquitin protein ligase JBrowse link 4 144,537,329 144,620,606 RGD:1624291
RGD:1600115
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:1624291
RGD:13792537
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:1624291
RGD:1600115
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:13792537
G Rfwd3 ring finger and WD repeat domain 3 JBrowse link 19 42,960,597 42,971,894 RGD:1624291
G RGD1565844 similar to RIKEN cDNA 1700045I19 JBrowse link X 32,495,573 32,496,646 RGD:13792537
G Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:1624291
RGD:1600115
G Rnf138 ring finger protein 138 JBrowse link 18 15,146,925 15,167,361 RGD:1600115
RGD:13792537
RGD:1624291
G Rnf168 ring finger protein 168 JBrowse link 11 71,721,242 71,743,421 RGD:1600115
RGD:1624291
G Rnf169 ring finger protein 169 JBrowse link 1 164,917,069 164,978,061 RGD:1624291
RGD:1600115
G Rnf8 ring finger protein 8 JBrowse link 20 8,285,380 8,309,858 RGD:1624291
RGD:13792537
RGD:1600115
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:1624291
RGD:13792537
RGD:1600115
G Rpa3 replication protein A3 JBrowse link 4 34,279,320 34,282,351 RGD:13792537
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 3 153,210,829 153,250,705 RGD:1624291
RGD:1600115
G Setmar SET domain and mariner transposase fusion gene JBrowse link 4 140,092,346 140,104,495 RGD:1624291
G Shld1 shieldin complex subunit 1 JBrowse link 3 125,318,682 125,396,705 RGD:1600115
RGD:1624291
G Shld2 shieldin complex subunit 2 JBrowse link 16 10,570,307 10,661,528 RGD:1624291
RGD:1600115
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:1600115
RGD:1624291
G Slf1 SMC5-SMC6 complex localization factor 1 JBrowse link 2 4,095,126 4,195,819 RGD:1624291
RGD:1600115
G Slf2 SMC5-SMC6 complex localization factor 2 JBrowse link 1 264,670,836 264,733,465 RGD:1624291
RGD:1600115
G Smarcad1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1` JBrowse link 4 95,884,020 95,945,248 RGD:1624291
RGD:1600115
G Smarcal1 Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 JBrowse link 9 79,943,775 79,990,230 RGD:1600115
RGD:1624291
G Smc5 structural maintenance of chromosomes 5 JBrowse link 1 240,977,898 241,046,273 RGD:1624291
G Smc6 structural maintenance of chromosomes 6 JBrowse link 6 36,941,233 36,995,920 RGD:1624291
RGD:1600115
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 9 119,675,750 119,818,620 RGD:1600115
RGD:1624291
G Stn1 STN1 subunit of CST complex JBrowse link 1 267,281,786 267,315,714 RGD:13792537
G Timeless timeless circadian regulator JBrowse link 7 2,643,288 2,667,329 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
RGD:1600115
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:1624291
RGD:1600115
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1624291
RGD:1600115
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1600115
RGD:1624291
G Wdr70 WD repeat domain 70 JBrowse link 2 56,944,462 57,196,522 RGD:13792537
G Wrap53 WD repeat containing, antisense to TP53 JBrowse link 10 56,169,024 56,185,800 RGD:1600115
RGD:1624291
G Zbtb7a zinc finger and BTB domain containing 7a JBrowse link 7 11,429,266 11,446,119 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19692
    cellular anatomical entity 19322
      site of DNA damage 76
        site of double-strand break 57
Path 2
Term Annotations click to browse term
  cellular_component 19692
    cellular anatomical entity 19322
      organelle 12479
        non-membrane-bounded organelle 4610
          intracellular non-membrane-bounded organelle 4591
            chromosome 1095
              site of DNA damage 76
                site of double-strand break 57
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.