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ONTOLOGY REPORT - ANNOTATIONS


Term:platelet-derived growth factor receptor-alpha signaling pathway
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Accession:GO:0035790 term browser browse the term
Definition:A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: PDGF receptor-alpha signaling pathway;   alphaPDGF receptor signaling pathway;   platelet-derived growth factor receptor-alpha signalling pathway
 related_synonym: PDGFR-alpha signaling pathway


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platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfra platelet derived growth factor receptor alpha involved_in ISO (PMID:2554309)
(MGI:5294530|PMID:20110689)
UniProt PMID:2554309 PMID:20110689 MGI:5294530 NCBI chrNW_004955447:16,570,652...16,613,410
Ensembl chrNW_004955447:16,569,909...16,612,373
JBrowse link
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO (MGI:4943654|PMID:19460854) UniProt PMID:19460854 MGI:4943654 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
JBrowse link
G Phf14 PHD finger protein 14 acts_upstream_of_or_within ISO (MGI:5426441|PMID:22730381) MGI PMID:22730381 MGI:5426441 NCBI chrNW_004955432:17,535,222...17,807,106
Ensembl chrNW_004955432:17,535,224...17,697,936
JBrowse link
regulation of platelet-derived growth factor receptor-alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene involved_in ISO (MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:6108066 NCBI chrNW_004955412:20,307,011...20,388,539
Ensembl chrNW_004955412:20,307,011...20,388,539
JBrowse link
G Cblb Cbl proto-oncogene B involved_in ISO (MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:6108066 NCBI chrNW_004955427:6,601,651...6,812,896
Ensembl chrNW_004955427:6,604,820...6,812,882
JBrowse link
G Ift20 intraflagellar transport 20 involved_in ISO (MGI:6108066|PMID:29237719) UniProt PMID:29237719 MGI:6108066 NCBI chrNW_004955481:4,799,548...4,807,751
Ensembl chrNW_004955481:4,799,548...4,807,751
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12107
    signaling 4326
      signal transduction 3843
        cell surface receptor signaling pathway 2057
          enzyme linked receptor protein signaling pathway 811
            transmembrane receptor protein tyrosine kinase signaling pathway 503
              platelet-derived growth factor receptor signaling pathway 61
                platelet-derived growth factor receptor-alpha signaling pathway 6
                  VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                  negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                  positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                  regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 12107
    biological regulation 8915
      regulation of biological process 8459
        regulation of cellular process 8034
          signal transduction 3843
            cell surface receptor signaling pathway 2057
              enzyme linked receptor protein signaling pathway 811
                transmembrane receptor protein tyrosine kinase signaling pathway 503
                  platelet-derived growth factor receptor signaling pathway 61
                    platelet-derived growth factor receptor-alpha signaling pathway 6
                      VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway 0
                      negative regulation of platelet-derived growth factor receptor-alpha signaling pathway 2
                      positive regulation of platelet-derived growth factor receptor-alpha signaling pathway 0
                      regulation of platelet-derived growth factor receptor-alpha signaling pathway + 5
paths to the root